Electrochemical and Ultraviolet–visible spectroscopic studies on the interaction of deoxyribonucleic acid with vitamin B6

Spectroscopic studies of the interaction between pirimicarb and calf thymus DNA

“…Many techniques have been applied for investigation of the interaction of DNA with small molecules, including UV spectrophotometry [15], fluorescence spectroscopy [16], circular dichroism spectroscopy [17], voltammetry [18], X-ray diffraction [19] and dynamic viscosity measurements [20]. In recent years, the application of chemometrics methods in the life science has drawn much attention, because they can provide information well beyond that obtained by conventional methods.…”

Studies on structures and properties of protonated pyridoxine, (PN+H) radicals and (PN+H)− anions with density functional theory

“…For example, pyridoxal-5 0 -phosphate is a form of vitamin B6 acting as cofactor of more than one hundred enzymes which catalyze the phosphorolytic cleavage of glycogen and a wide variety of metabolic reactions of amino acids (racemizations, transaminations, a-decarboxylations, aldolic cleavages, b-and c-eliminations and replacements) [3]. One's body needs vitamin B6 to make hemoglobin, which carries oxygen to tissues [5]. Apart from the above mentioned general functions, recent research has revealed that vitamin B6 play a crucial role in protecting cells from oxidative stress because the vitamin has been shown to exhibit antioxidant activity that even exceeds that of vitamin C and E, although vitamin B6 do not classified as an antioxidant compound [1,10].…”

“…Vitamin B6 has attracted a lot of attention because not only it serves a role in enzymatic reactions but also it exhibits antioxidant activity [1][2][3][4][5][6][7][8][9][10][11][12]. For example, pyridoxal-5 0 -phosphate is a form of vitamin B6 acting as cofactor of more than one hundred enzymes which catalyze the phosphorolytic cleavage of glycogen and a wide variety of metabolic reactions of amino acids (racemizations, transaminations, a-decarboxylations, aldolic cleavages, b-and c-eliminations and replacements) [3].…”

Detection of B6 Vitamers in Grain Products: Experimental and Computational Studies

“…Interestingly, vitamin B 6 has recently been found to be a potent antioxidant, with the particular ability to quench reactive oxygen species such as superoxide, and singlet oxygen (Tambasco-Studart et al 2005). Recent studies have shown that DNA damage resulting from deficiencies of micronutrients such as vitamins B 6 , and B 12 are likely to be major contributing factors to cancer, as vitamin B 6 plays a crucial role in 1-carbon metabolism, which involve DNA synthesis, and methylation (Larsson et al 2005;Liu et al 2008).…”