Electrochemical and PEC platforms for miRNA and other epigenetic markers of cancer diseases: Recent updates

Sfragano, Patrick Severin; Pillozzi, Serena; Palchetti, Ilaria

doi:10.1016/j.elecom.2021.106929

Cited by 26 publications

(11 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The detection of CTCs in sarcomas has been proposed to lead to better understanding of the efficacy of therapy and of drug resistance [ 177 , 178 ]. The advent of new technologies to determine and monitor these biological entities in LB [ 179 , 180 , 181 ] holds great promise for developing minimally invasive methods to improve patient care.…”

Section: Circulating Biomarkersmentioning

confidence: 99%

Soft Tissue Sarcoma: An Insight on Biomarkers at Molecular, Metabolic and Cellular Level

Pillozzi

Bernini

Palchetti

et al. 2021

Cancers

Self Cite

View full text Add to dashboard Cite

Soft tissue sarcomas (STSs) are a heterogeneous group of rare tumors. Although constituting only 1% of all human malignancies, STSs represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. Over 100 histologic subtypes have been characterized to date (occurring predominantly in the trunk, extremity, and retroperitoneum), and many more are being discovered due to molecular profiling. STS mortality remains high, despite adjuvant chemotherapy. New prognostic stratification markers are needed to help identify patients at risk of recurrence and possibly apply more intensive or novel treatments. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the most relevant cellular, molecular and metabolic biomarkers for STS, and highlight advances in STS-related biomarker research.

show abstract

Section: Circulating Biomarkersmentioning

confidence: 99%

Soft Tissue Sarcoma: An Insight on Biomarkers at Molecular, Metabolic and Cellular Level

Pillozzi

Bernini

Palchetti

et al. 2021

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

“…Currently, several reviews have focused on the progress of PEC sensing technologies and their applications to various analytes. [28][29][30][31][32][33] However, to the best of our knowledge, an integral overview of PEC sensors for contamination analysis in agricultural fields has not been published in recent years.…”

Section: Introductionmentioning

confidence: 99%

Research progress on photoelectrochemical sensors for contamination analysis in agricultural fields

et al. 2022

View full text Add to dashboard Cite

The establishment of rapid and efficient contamination detection methods in agricultural fields is of great significance for safeguarding agricultural production and human health, and for ensuring the healthy development of agricultural industries. As a booming analytical method, photoelectrochemical (PEC) sensors, which combine the advantages of electrochemical analysis and optical analysis, have received increasing research attention. Due to the complete separation of the excitation source (light) and the detection signal (current), the background signal of PEC sensors is greatly decreased, and their sensitivity is high. This review aims to cover the advances in PEC sensors for contamination analysis in agricultural fields over the past five years, including analysis of heavy metals, antibiotics, pesticides, and toxins. The future prospects in this field are also discussed.

show abstract

“…Electrochemical biosensors are powerful tools that allow for cost-effective, easy, and fast detection and/or monitoring of analytes in clinical diagnostics [7][8][9][10][11][12], and are often employed in the framework of point-of-care testing (PoCT). Peptides represent a promising class of affinity biorecognition elements that can be coupled to electrochemical transducers.…”

Section: Introductionmentioning

confidence: 99%

The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics

et al. 2021

Self Cite

View full text Add to dashboard Cite

Peptides represent a promising class of biorecognition elements that can be coupled to electrochemical transducers. The benefits lie mainly in their stability and selectivity toward a target analyte. Furthermore, they can be synthesized rather easily and modified with specific functional groups, thus making them suitable for the development of novel architectures for biosensing platforms, as well as alternative labelling tools. Peptides have also been proposed as antibiofouling agents. Indeed, biofouling caused by the accumulation of biomolecules on electrode surfaces is one of the major issues and challenges to be addressed in the practical application of electrochemical biosensors. In this review, we summarise trends from the last three years in the design and development of electrochemical biosensors using synthetic peptides. The different roles of peptides in the design of electrochemical biosensors are described. The main procedures of selection and synthesis are discussed. Selected applications in clinical diagnostics are also described.

show abstract

Electrochemical and PEC platforms for miRNA and other epigenetic markers of cancer diseases: Recent updates

Cited by 26 publications

References 105 publications

Soft Tissue Sarcoma: An Insight on Biomarkers at Molecular, Metabolic and Cellular Level

Soft Tissue Sarcoma: An Insight on Biomarkers at Molecular, Metabolic and Cellular Level

Research progress on photoelectrochemical sensors for contamination analysis in agricultural fields

The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics

Contact Info

Product

Resources

About