Electrochemical Activity of Methionine at Graphite Electrode Modified with Gold Nanoparticles

Перевезенцева, Дарья Олеговна; Skirdin, K. V.; Gorchakov, Eduard; Bimatov, Vladimir

doi:10.4028/www.scientific.net/kem.685.563

Cited by 11 publications

(11 citation statements)

References 13 publications

(17 reference statements)

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Section: Electrochemical Analysis Of Amino Acidsmentioning

confidence: 90%

“…Noble metals and their alloys, as expected, are the main modifiers used in electrochemical methionine sensors [ 181 , 182 , 183 , 184 ]. These noble metals are exploited either in monometallic form [ 181 , 184 ] or as a bimetallic compound, e.g., Ru/Pt [ 182 ] and Ag/Au [ 183 ]. Bimetallic modifiers are expected to surpass their monometallic counterparts through improving the effective surface area, electron transfer rate, biocompatibility, electrocatalytic activity and invulnerability against interfering species and/or intermediate by-products of electrochemical reactions.…”

Section: Electrochemical Analysis Of Amino Acidsmentioning

confidence: 90%

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Electrochemical Amino Acid Sensing: A Review on Challenges and Achievements

Moulaee

Neri

2021

Biosensors

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The rapid growth of research in electrochemistry in the last decade has resulted in a significant advancement in exploiting electrochemical strategies for assessing biological substances. Among these, amino acids are of utmost interest due to their key role in human health. Indeed, an unbalanced amino acid level is the origin of several metabolic and genetic diseases, which has led to a great need for effective and reliable evaluation methods. This review is an effort to summarize and present both challenges and achievements in electrochemical amino acid sensing from the last decade (from 2010 onwards) to show where limitations and advantages stem from. In this review, we place special emphasis on five well-known electroactive amino acids, namely cysteine, tyrosine, tryptophan, methionine and histidine. The recent research and achievements in this area and significant performance metrics of the proposed electrochemical sensors, including the limit of detection, sensitivity, stability, linear dynamic range(s) and applicability in real sample analysis, are summarized and presented in separate sections. More than 400 recent scientific studies were included in this review to portray a rich set of ideas and exemplify the capabilities of the electrochemical strategies to detect these essential biomolecules at trace and even ultra-trace levels. Finally, we discuss, in the last section, the remaining issues and the opportunities to push the boundaries of our knowledge in amino acid electrochemistry even further.

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Section: Electrochemical Analysis Of Amino Acidsmentioning

confidence: 90%

Section: Electrochemical Analysis Of Amino Acidsmentioning

confidence: 90%

Electrochemical Amino Acid Sensing: A Review on Challenges and Achievements

Moulaee

Neri

2021

Biosensors

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show abstract

“…The linear range and detection limit of 0.05-5.0 mM and 95 µM were obtained. Some electrochemical sensors for Met detection are presented in Table 6 and their electroanalytical parameters were compared [164][165][166][167]. (more comprehensive data can be found in Table S6 in SI).…”

Section: Methioninementioning

confidence: 99%

Electrochemical approaches based on micro- and nanomaterials for diagnosing oxidative stress

et al. 2023

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This review article comprehensively discusses the various electrochemical approaches for measuring and detecting oxidative stress biomarkers and enzymes, particularly reactive oxygen/ nitrogen species, highly reactive chemical molecules, which are the byproducts of normal aerobic metabolism and can oxidize cellular components such as DNA, lipids, and proteins. First, we address the latest research on the electrochemical determination of reactive oxygen species generating enzymes, followed by detection of oxidative stress biomarkers, and final determination of total antioxidant activity (endogenous and exogenous). Most electrochemical sensing platforms exploited the unique properties of micro and nanomaterials such as carbon nanomaterials, metal or metal oxide nanoparticles (NPs), conductive polymers and metal-nano compounds, which have been mainly used for enhancing the electrocatalytic response of sensors/biosensors. The performance of the electroanalytical device commonly measured by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) in terms of detection limit, sensitivity, and linear range of detection was also discussed. This article provides a comprehensive review of electrode fabrication, characterization and evaluation of their performances, which are assisting to design and manufacture an appropriate electrochemical (bio)sensor for medical and clinical applications. The key points such as accessibility, affordability, rapidity, low cost, and high sensitivity of the electrochemical sensing devices were also highlighted for the diagnosis of oxidative stress. Overall, this review brings a timely discussion on past and current approaches for developing electrochemical sensors and biosensors mainly based on micro and nanomaterials for the diagnosis of oxidative stress.

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“…Methionine is an essential sulphur-containing amino acid that is part of the synthesis of epinephrine, choline and creatinine. Its deficiency leads to metabolic disorders, toxaemia, muscle paralysis, depression and impaired growth [6]. Methionine-deficient diets also result in elevated blood spermidine; thus, methionine supplements are given to lower blood histamine by increasing its breakdown.…”

Section: Introductionmentioning

confidence: 99%

Screen-printed electrodes modified with green-synthesized gold nanoparticles for the electrochemical determination of aminothiols

Bernardo-Boongaling

Serrano

García-Guzmán

et al. 2019

Journal of Electroanalytical Chemistry

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Commercially available gold screen-printed electrodes cured at high temperature were modified or functionalized at the surface with gold nanoparticles, mainly produced by a green synthesis method, and other carbon-based nanomaterials in order to enhance the electron transfer between the sulfhydryl groups of the aminothiols cysteine (Cys), methionine (Met), glutathione (GSH) and homocysteine (hCys) and the electrode. The electrochemical characterization by cyclic and differential pulse voltammetry of some of the modified electrodes showed an improved performance in terms of sensitivity, reproducibility, repeatability, linearity range and limits of detection (12, 1, 0.2 and 1 μmol L -1 for Cys, Met, GSH, hCys, respectively) and quantification (40, 2, 0.5 and 2 μmol L -1 for Cys, Met, GSH, hCys, respectively) as compared to unmodified units. Then, some of these modified devices were successfully applied to the determination of cysteine and methionine in dietary supplements by means of liquid chromatography with amperometric detection.

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Electrochemical Activity of Methionine at Graphite Electrode Modified with Gold Nanoparticles

Cited by 11 publications

References 13 publications

Electrochemical Amino Acid Sensing: A Review on Challenges and Achievements

Electrochemical Amino Acid Sensing: A Review on Challenges and Achievements

Electrochemical approaches based on micro- and nanomaterials for diagnosing oxidative stress

Screen-printed electrodes modified with green-synthesized gold nanoparticles for the electrochemical determination of aminothiols

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