Electrocatalytic Oxidation of Folic Acid on Carbon Paste Electrode Modified by Nickel Ions Dispersed into Poly(o‐anisidine) Film

Abstract

Poly(o-anisidine) (POA) was formed by successive cyclic voltammetry in monomer solution containing sodium dodecyl sulfate (SDS) at the surface of carbon paste electrode. Then Ni(II) ions were incorporated to electrode by immersion of the polymeric modified electrode having amine group in 0.1 M Ni(II) ion solution. Cyclic voltammetric and chronoamperometric experiments were used for the electrochemical study of this modified electrode; a good redox behavior of Ni(OH) 2 /NiOOH couple at the surface of electrode can be observed. The capability of this modified electrode for catalytic oxidation of folic acid was demonstrated. The amount of a and surface coverage (G*) of the redox species and catalytic chemical reaction rate constant (k) for folic acid oxidation were calculated. The catalytic oxidation peak current of folic acid was linearly dependent on its concentration and a linear calibration curve was obtained in the range of 0.1 to 5 mM with a correlation coefficient of 0.9994. The limit of detection (3s) was determined as 0.091 mM. This electrocatalytic oxidation was used as simple, selective and precise voltammetric method for determination of folic acid in pharmaceutical preparations.

Application of a Carbon‐Paste Electrode Modified with 2,7‐Bis(ferrocenyl ethyl)fluoren‐9‐one and Carbon Nanotubes for Voltammetric Determination of Levodopa in the Presence of Uric Acid and Folic Acid

“…Several techniques have been applied for the determination of FA in pharmaceutical formulations and biological fluids. Due to the advantages of relatively low cost, fast response, simple instrumentation, high sensitivity, facile miniaturization, and low power requirement, numerous voltammetric methods have been developed for determination of FA [36][37][38][39][40][41].…”

Voltammetric sensor based on ordered mesoporous carbon for folic acid determination

“…Electrochemical methods have also been used and attracted enormous interest due to its advantages of simplicity, rapid response, excellent reproducibility, good stability, low cost and low detection limit, etc. [26][27][28].…”

Facile one-step direct electrodeposition of bismuth nanowires on glassy carbon electrode for selective determination of folic acid

“…chemically modified electrodes have been used for the quantification of FA which include carbon nanotubes [1,32,33], carbon paste [34,35], ordered mesoporous carbon [36,37], calixarene [38], lead film electrode [39], nanostructured α-Fe 2 O 3 [40], phosphomolybdicpolypyrrole film [41] and 2-mercaptobenzothiazole self-assembled gold electrode [42]. All these modified electrodes are used for the determination of FA based on its oxidation reaction.…”