Electrocardiography Screening for Hypertrophic Cardiomyopathy

Campbell, Matthew; Zhou, Xin‐Da; Han, Chia Y.; Abrishami, Hedayat; Webster, Melanie; Miyake, Christina Y.; Knilans, Timothy K.; Czosek, Richard J.

doi:10.1111/pace.12913

Cited by 9 publications

(6 citation statements)

References 22 publications

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“…These insights indicate that while ECG can provide valuable information, it may not be comprehensive enough for accurate HCM identification when used in isolation. [34][35][36] Despite advancements, at present the diagnosis of HCM still must involve a combination of tests including echocardiography, genetic testing, and clinical evaluation.…”

Section: Discussionmentioning

confidence: 99%

The Majority of Participants With Suspected Hypertrophic Cardiomyopathy Documented During Screening Echocardiography Have a Normal Electrocardiogram

Movahed,

Irannejad,

Bates

2024

Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine

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Background: Patients with hypertrophic cardiomyopathy (HCM) usually have abnormal electrocardiograms consistent with left ventricular hypertrophy (LVH). The goal of this study was to evaluate the prevalence of abnormal ECG findings (LVH, T wave inversion, left bundle branch block, and left atrial enlargement) in participants with suspected HCM detected during screening echocardiography. Method: The Anthony Bates Foundation has been performing screening echocardiography across the United States for the prevention of sudden death since 2001. A total of 682 subjects between the ages of 8 and 71 underwent echocardiographic screening together with ECG documentation. We evaluated the prevalence of abnormal ECG in participants with suspected HCM defined as any left ventricular wall thickness ≥15 mm. Results: The prevalence of LVH and T wave inversion were higher in HCM subjects as expected [HCM occurred in 23.5% (4/17) vs. 5.6% (37/665), P = 0.002, T wave inversion occurred in 17.6% (3/17) vs. 4.1% (27/664), P = 0.007]. However, despite adding these 2 common ECG abnormalities in this population, the presence of detected abnormal ECG remained less than 25% (23.5% of HCM subjects had LVH or T wave inversion on ECG vs. 8.7% of control, P = 0.036). Left bundle branch block or abnormal left atrium on ECG were not found in any participants with suspected HCM. Conclusions: The prevalence of abnormal ECG in the participants with suspected HCM detected during screening echocardiography is less than 25%. This suggests that ECG alone is not a sensitive marker for the detection of HCM.

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Section: Discussionmentioning

confidence: 99%

The Majority of Participants With Suspected Hypertrophic Cardiomyopathy Documented During Screening Echocardiography Have a Normal Electrocardiogram

Movahed,

Irannejad,

Bates

2024

Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine

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“…Another study concentrated on classifying HCM patients through ECG analysis. These insights indicate that while ECG can provide valuable information, it may not be comprehensive enough for accurate HCM identification when used in isolation (27)(28)(29). Despite advancements, at present the diagnosis of HCM still must involve a combination of tests including echocardiography, genetic testing, and clinical evaluation.…”

Section: Discussionmentioning

confidence: 99%

The majority of participants with suspected hypertrophic cardiomyopathy documented during screening Echocardiography have a normal electrocardiogram (EKG)

Movahed

2024

Preprint

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“…[15] Previous studies had indicated that a computer-automated ECG screening algorithm can perform well in cardiomyopathy screening. [16] Moreover, our model was constructed from statistical frameworks, therefore, although the procedure of interpretation of ECG was left out for reducing the requirement of medical expertise, our model was easier to explain than models constructed from machine learning without the "black box" phenomena. [17] Historically, many electro cardiologists and clinicians have continuously explored the relationship between ECG and cardiomyopathy.…”

Section: Discussionmentioning

confidence: 99%

Simple screening model based on electrocardiogram for patients with dilated cardiomyopathy

Wang¹,

Zhang²,

Yang³

et al. 2023

Medicine

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Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Therefore, screening and early diagnosis of potential DCM patients is beneficial. Electrocardiogram (ECG) can be an inexpensive and easily available screening tool. We aimed to construct a simple screening model for DCM based on electrocardiogram. In this retrospective observational study, we consecutively enrolled 117 DCM patients between July 1, 2016 and July 1, 2021 as the DCM group, while 117 patients hospitalized in the same period with normal echocardiography and ECG were selected as the non-DCM group. Patients were randomly assigned to the training and validation sets at 8:2. ECG parameters of left ventricular related leads were exacted. Logistic regression was performed to evaluate screening indicators of ECG parameters and a nomogram was conducted. The screening ability of the model was evaluated using receiver operating characteristic analysis. Furthermore, the nomogram was assessed using calibration curve and decision curve analysis. Screening indicators included in the nomogram were the amplitude of S wave in V1 and V3 leads, the amplitude of R wave in aVF and V6 leads, and PR interval. The nomogram performed satisfactory discrimination in the training (area under the receiver operating characteristic curve = 0.904) and validation (area under the receiver operating characteristic curve = 0.878) sets and good calibration (Hosmer–Lemeshow P = .066). Decision curve analysis demonstrated the model can generate a net benefit of 0.33 when the threshold probability was 0.543. The nomogram based on electrocardiogram is a simple and practical screening tool for potential DCM patients.

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Electrocardiography Screening for Hypertrophic Cardiomyopathy

Abstract: Computer-automated ECG screening for HCM is feasible. Evaluation of automated ECG algorithms in larger and more diverse populations is warranted.

Cited by 9 publications

References 22 publications

The Majority of Participants With Suspected Hypertrophic Cardiomyopathy Documented During Screening Echocardiography Have a Normal Electrocardiogram

The Majority of Participants With Suspected Hypertrophic Cardiomyopathy Documented During Screening Echocardiography Have a Normal Electrocardiogram

The majority of participants with suspected hypertrophic cardiomyopathy documented during screening Echocardiography have a normal electrocardiogram (EKG)

Simple screening model based on electrocardiogram for patients with dilated cardiomyopathy

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