Electrocardiographic changes and troponin T levels in children with severe malaria anemia and heart failure

Abstract

Prolonged QTc was more prevalent in children with severe malaria anemia compared to those without anemia, suggesting that children with severe malaria anemia were more prone to arrhythmias. The median cTnT value in the subjects was not significantly lower than that in controls, suggesting that children with severe malaria anemia are not prone to myocardial injury any more than those with uncomplicated malaria without anemia.

Blood Pressure Profile of Apparently Healthy Primary School Children in Delta State, Nigeria: Impact of Social Factors and Anthropometric Variables

“…The mean systolic and diastolic blood pressure of subjects drawn from public schools was significantly higher than those drawn from the private schools. This is possible because the children from public schools were slightly older than those from private schools as evidenced by the difference in the mean ages of the subjects in both schools and this finding is similar to what was reported by Sadoh et al [13]. The slight difference in the ages amongst these groups of children stems from the fact that most of these children in the public schools often enroll at a later age compared with their counterparts in the private schools.…”

“…This observation may be due to the fact that factors predisposing these children to hypertension are multi-factorial and may not really be limited to the school type attended by the subjects. The finding is however at variance with the outcome of the works done by Sadoh et al [13] in Benin City and Sabapathy et al [24] in India. While Sadoh et al [13] reported a higher prevalence of hypertension among school children in public schools compared to those that attend private school, Sabapathy et al [24] reported a higher prevalence of hypertension among children in private schools which they attributed to high burden of obesity among such children.…”

“…These Nigerian studies were carried out in both public (attended mostly by low and medium social-economic groups) and private schools (attended mostly by children from rich homes). It is believed that using only one school type (public or private) could yield erroneous results that are not reflective of what is obtainable in the general population as there are marked socioeconomic disparities between students in both types of schools which could affect the burden of the disease [12] [13].…”

Reduced cardiotoxicity and increased oral efficacy of artemether polymeric nanocapsules in Plasmodium berghei-infected mice

“…There are different pathways which P. falciparum infection can trigger cardiac disorders. Parasitized red blood cells can occlude myocardial capillaries, leading to ischaemic cardiomyopathy and dilated heart (Mohsen et al 2001; Costenaro et al 2011); high levels of tumour necrosis factor (TNF- α ) may play a role in inflammatory process at heart, impairing myocardial function (Torre-Amione et al 1996); and hypoxia induced by severe anaemia may cause ischaemic myocardial injury with prolonged QTc interval of electrocardiogram (ECG), as frequently observed in children (Sadoh and Uduebor, 2016).…”

Turkish Society of Cardiology Consensus Paper onThe Rational Use of Cardiac Troponins in Daily Practice

“…Although there is no study investigating the rise in cTn levels in different hemoglobin levels in large patient populations, severe anemia was shown to be related with increased troponin levels in children with malaria (132, 133). Severe anemia has also been found to relate with mortality in patients with MI and HF (134, 135).…”