Electroanalytical study of fluvoxamine

Abstract

Fluvoxamine (FVX) can be reduced at a mercury-drop electrode, with a maximum peak current intensity being obtained at a potential of -0.7 V vs. Ag/ AgCl, in an aqueous electrolyte solution of pH 2. The compound was determined in a pharmaceutical product and in spiked human serum by square-wave adsorptivestripping voltammetry (SWAdSV) after accumulation at the electrode surface, under batch conditions. Because the presence of dissolved oxygen did not interfere significantly with the analysis, it was also possible to determine FVX in the pharmaceutical product by use of a flow-injection analysis (FIA) system with SWAdSV detection. The methods developed were validated and successfully applied to the quantification of FVX in a pharmaceutical product. Recoveries between 76 and 89% were obtained in serum analysis. The FIASWAdSV method enabled analysis of up to 120 samples per hour at reduced cost, implying the possibility of competing with the chromatographic methods usually used for this analysis.

Quality assessment of fluoxetine and fluvoxamine pharmaceutical formulations purchased in different countries or via the Internet by 19F and 2D DOSY 1H NMR

“…Our data are in agreement with those reported by several authors [1,2,9,12,13,15,[30][31][32][33][34][35][36][37] who, Table 7). The intrabatch variability is correct as it is <5% for all the 19 formulations of FLX and FLV assayed except one (formulation 4), and even <2% for twelve pharmaceutical preparations.…”

Probing trace levels of prometryn solutions: from test samples in the lab toward real samples with tap water

“…Electrochemical techniques are also employed in detecting prometryn, although electrochemical sensors based on mercury electrodes [9][10][11] have negative environmental implications. Motivated by the need to develop sensitive and selective methods to monitor residual amounts of prometryn, in this study we combine the highly sensitive and selective surface-enhanced Raman scattering (SERS) [12] with advanced computational data analysis in order to detect prometryn below the threshold allowed for drinking water.…”

Surfactant to dye binding degree method for the determination of fluvoxamine maleate and citalopram hydrobromide in pharmaceuticals

“…1B), is also a selective serotonin reuptake inhibitor with a very broad spectrum of therapeutic activity against depression, anxiety, and obsessive and impulse control disorders [1]. A number of analytical methods used for the determination of fluvoxamine and citalopram in pharmaceutical preparations have been proposed including spectrophotometry [2][3][4][5][6][7][8], spectrofluorimetry [9][10][11][12], liquid chromatography [13,14], capillary electrophoresis [15,16], gas chromatography [17][18][19], densitometric thin layer chromatography [20] and electrochemical techniques [21][22][23][24][25]. However, the quality control of such drugs in pharmaceutical formulations requires a simple, rapid and low cost analytical method.…”