Electroanalytical method for the determination of methylparaben

Naik, Keerti M.; Nandibewoor, Sharanappa T.

doi:10.1016/j.sna.2014.03.033

Cited by 44 publications

(15 citation statements)

References 26 publications

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“…The plot of square root of scan rate with the peak current showed a linear relationship in the range of 10 to 50 mV s -1 which is of diffusion controlled process [21].…”

Section: Influence Of Scan Ratementioning

confidence: 85%

Novel electroanalysis of hydroxyurea at glassy carbon and gold electrode surfaces

Naik¹,

Nandibewoor²

2014

J. Electrochem. Sci. Eng.

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A simple and a novel electroanalysis of hydroxyurea (HU) drug at glassy carbon and gold electrode was investigated for the first time using cyclic, linear sweep and differential pulse voltammetric techniques. The oxidation of HU was irreversible and exhibited a diffusion controlled process on both electrodes. The oxidation mechanism was proposed. The dependence of the current on pH, the concentration, nature of buffer, and scan rate was investigated to optimize the experimental conditions for the determination of HU. It was found that the optimum buffer pH was 7.0, a physiological pH. In the range of 0.01 to 1.0 mM, the current measured by differential pulse voltammetry showed a linear relationship with HU concentration with limit of detection of 0.46 µM for glassy carbon electrode and 0.92 µM for gold electrode. In addition, reproducibility, precision and accuracy of the method were checked as well. The developed method was successfully applied to HU determination in pharmaceutical formulation and human biological fluids. The method finds its applications in quality control laboratories and pharmacokinetics.

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“…The plot of square root of scan rate with the peak current showed a linear relationship in the range of 10 to 50 mV s -1 which is of diffusion controlled process [21].…”

Section: Influence Of Scan Ratementioning

confidence: 85%

Novel electroanalysis of hydroxyurea at glassy carbon and gold electrode surfaces

Naik¹,

Nandibewoor²

2014

J. Electrochem. Sci. Eng.

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“…A selectivity study of both rGO and CNC–rGO nanocomposite modified electrodes for MP determination was carried out using a few possible interference substances such as ascorbic acid, benzoic acid, salicylic acid, and citric acid. Ascorbic acid was selected because it is an electroactive species [66], while salicylic acid, benzoic acid, and citric acid may be present in pharmaceutical formulations [67,68,69,70,71]. As can be seen in Figure 8, several common interfering species displayed a much lower current response at potential 0.75 V, while salicylic acid showed a significant peak at potential 0.85 V. Both rGO and CNC-rGO nanocomposite modified electrodes exhibited an almost similar current trend with a slightly higher current in salicylic acid solution.…”

Section: Resultsmentioning

confidence: 99%

A New Sensor for Methyl Paraben Using an Electrode Made of a Cellulose Nanocrystal–Reduced Graphene Oxide Nanocomposite

Khalid

Arip

Jasmani

et al. 2019

Sensors

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A new cellulose nanocrystal–reduced graphene oxide (CNC–rGO) nanocomposite was successfully used for mediatorless electrochemical sensing of methyl paraben (MP). Fourier-transform infrared spectroscopy (FTIR) and field-emission scanning electron microscopy (FESEM) studies confirmed the formation of the CNC–rGO nanocomposite. Cyclic voltammetry (CV) studies of the nanocomposite showed quasi-reversible redox behavior. Differential pulse voltammetry (DPV) was employed for the sensor optimization. Under optimized conditions, the sensor demonstrated a linear calibration curve in the range of 2 × 10−4–9 × 10−4 M with a limit of detection (LOD) of 1 × 10−4 M. The MP sensor showed good reproducibility with a relative standard deviation (RSD) of about 8.20%. The sensor also exhibited good stability and repeatability toward MP determinations. Analysis of MP in cream samples showed recovery percentages between 83% and 106%. Advantages of this sensor are the possibility for the determination of higher concentrations of MP when compared with most other reported sensors for MP. The CNC–rGO nanocomposite-based sensor also depicted good reproducibility and reusability compared to the rGO-based sensor. Furthermore, the CNC–rGO nanocomposite sensor showed good selectivity toward MP with little interference from easily oxidizable species such as ascorbic acid.

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“…Where I pa refers to the anodic peak current, n is the number of electrons transferred, A 0 is the surface area of the electrode, D 0 is the diffusion coefficient, υ is the scan rate (V.s −1 ) and C 0 is the concentration of K 4 Fe (CN) 6 . For 1.0 mM K 4 Fe (CN) 6 , n=1, D o =7.6×10 −6 cm 2 s −1 , then from the slope of the plot of I pa vs. υ 1/2 , the electro‐active area was calculated . In our experiment, electro‐active areas of GPE and GCE were found to be 0.2207 and 0.118 cm 2 .…”

Section: Resultsmentioning

confidence: 99%

Challenge Approach of an Inexpensive Electrochemical Sensor for Rapid Selective Determination of two Non‐classical β‐Lactams in Presence of Different Degradants and Interference Substances

et al. 2017

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An inexpensive stability−indicating anodic voltammetric method for rapid determination of two non‐classical β‐lactam antibiotics; Meropenem (MP) and Ertapenem (EP) has been developed and validated. The method was based on the enhancement of voltammetric response at a disposable graphite pencil electrode (GPE). Differential pulse voltammetric (DPV) method was developed for quantification of both drugs in B−R buffer solution (pH 2.0) at GPE. The GPE displayed very good voltammetric behavior with significant enhancement of the peak current compared to glassy carbon electrode (GCE). Stress stability studies were performed using 0.5 M of either HCl or NaOH and H2O2. Mass and infrared spectroscopy were used for identification of degradants and their pathways were illustrated. Under optimal conditions, the peak currents showed a linear dependence with drug concentrations. The achieved limits of detection (LOD) were 1.23, 2.07 and 1.50 μM for MP and two waves of EP, respectively. The developed voltammetric method was successfully applied for direct determination of MP and EP in drug substances, pharmaceutical vials and in presence of either their corresponding hydrolytic, oxidative‐degradants or interfering substances with no potential interferences. The differential pulse voltammograms were highly advantageous and applicable in QC laboratories for rapid, selective micro‐determination of MP and EP.

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Electroanalytical method for the determination of methylparaben

Cited by 44 publications

References 26 publications

Novel electroanalysis of hydroxyurea at glassy carbon and gold electrode surfaces

Novel electroanalysis of hydroxyurea at glassy carbon and gold electrode surfaces

A New Sensor for Methyl Paraben Using an Electrode Made of a Cellulose Nanocrystal–Reduced Graphene Oxide Nanocomposite

Challenge Approach of an Inexpensive Electrochemical Sensor for Rapid Selective Determination of two Non‐classical β‐Lactams in Presence of Different Degradants and Interference Substances

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