Electroanalytical characteristics of antipsychotic drug ziprasidone and its determination in pharmaceuticals and serum samples on solid electrodes

Electrochemical and spectrophotometric characterisation of protein kinase inhibitor and anticancer drug danusertib

“…6A and B, it is proposed that the oxidation involves the piperazine moiety. The redox behaviour of piperazine containing compounds has been previously reported [22][23][24][25][26]. Considering that in acid media piperazine moiety is protonated (pK a1 ~ 7 and pK a2 ~ 3), the electrochemical oxidation of danusertib at peak 3 a occurs with the transfer of two electrons and two protons from the nitrogen atom in the proximity of the methyl group leading to the formation of iminium cation, Scheme 2C, which is hydrolysed forming an amine derivative and formaldehyde [26].…”

“…Electroanalysis has been successfully used to determine the redox mechanism of several pharmaceutical compounds and to quantitate different types of drugs [19][20][21][22][23][24].…”

Antioxidant activity of indole-based melatonin analogues in erythrocytes and their voltammetric characterization

“…In order to characterize the electrochemical process that occurs on the glassy carbon electrode, both pH, nature of the buffer and scan rate studies were carried out in the potential range from −0.25 to 1.6 V. Cyclic voltammetry (CV) experiments were achieved over a range from acidic (0.1M H 2 SO 4 ) to alkaline (pH 12.00) in acidic solutions and different buffer aqueous media. For the quantitative determination, DPV and SWV methods were applied to the selected synthesized derivatives [35][36][37] . For the synthesized compounds, the peak currents and peak potentials were determined in different supporting electrolytes such as H 2 SO 4 , phosphate, acetate, and Britton-Robison buffers containing 40, 50, 20, and 30% methanol (v/v) to maintain solubility for 1f, 1g, 1y, and 1u, respectively.…”

“…Although the exact oxidation mechanism was not determined, some conclusions about the potentially electroactive centers under working conditions could be reached. From the CV curves, the main voltammetric behavior of indole and methoxy benzene derivatives, which are structurally related to the mechanism of oxidation of synthesized indole compounds, may be postulated by the oxidation of these groups [26][27][28][29][35][36][37][38][39][40][41] . Our results on model compounds show similar behavior that the electroactive center corresponding to the main anodic response was the nitrogen atom on the indole ring.…”

“…In addition to, the methoxy benzene anodic response in compound 1u was obtained as the second oxidation step. Indole and its derivatives are extensively metabolized in vivo [26][27][28][29]36,37 .…”