Electroacupuncture Stimulation Suppresses the Increase in Alcohol-Drinking Behavior in Restricted Rats

Yoshimoto, Kanji; Kato, Baku; Sakai, Kazumi; Shibata, Masaru; Yano, Tadashi; Yasuhara, Masahiro

doi:10.1097/00000374-200106001-00015

Cited by 19 publications

(18 citation statements)

References 15 publications

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“…There is a considerable body of literature on the subject of EA frequency. A frequency of 100 Hz has proved effective in increasing preprodynorphin mRNA expression, as well as accelerating the release of dynorphin in the CNS (Guo et al, 1996; Yoshimoto et al, 2001; Han, 2003). Five animals after the single 2 Hz EA treatment were allowed to continue drinking EtOH under the intermittent-access drinking procedure and were administered high frequency (100 Hz) EA at ST36 after a two week recovery from the single 2 Hz EA administration.…”

Section: Methodsmentioning

confidence: 99%

“…However, many questions regarding the efficacy and basic mechanisms of acupuncture in general, and for alcohol abuse in particular, have not been well addressed. Previous clinical and preclinical studies have shown that acupuncture is an effective treatment for alcohol drinking behaviors and alcohol withdrawal syndrome (Yoshimoto et al, 2001; Karst et al, 2002; Trumpler et al, 2003; Kim et al, 2005a; Kunz et al, 2007; Overstreet et al, 2008). More recent animal studies have shown that acupuncture at the specific acupoint Shenmen (HT7) can normalize dopamine release induced by both the presence and withdrawal of ethanol (EtOH) in the nucleus accumbens (Yoon et al, 2004; Zhao et al, 2006) and can inhibit the activity of GABA neurons in the ventral tegmental area and reduce EtOH self-administration (Yang et al., 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, it has been shown that EA at ST36 increased μ-receptor binding sites (Gao et al, 1997; Yun et al, 2002). Alternated frequency EA between 2 and 100 Hz or a single low frequency (2 Hz) at ST36 decreased alcohol intake in inbred alcohol-preferring P (iP) rats (Overstreet et al, 2008) and physically restricted Sprague-Dawley (SD) rats (Yoshimoto et al, 2001; Overstreet et al, 2008). However, in Overstreet’s study, it showed that EA blocked the increase of alcohol intake induced by alcohol deprivation, but not ongoing drinking.…”

Section: Introductionmentioning

confidence: 99%

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Low frequency electroacupuncture selectively decreases voluntarily ethanol intake in rats

Zou

2011

Brain Research Bulletin

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Although there is increasing clinical acceptance of acupuncture and electroacupuncture (EA) as a treatment of substance abuse-related disorders, our understanding of this treatment remains incomplete. Previous clinical and pre-clinical studies have shown that acupuncture and EA are effective in reducing ethanol consumption. Recent studies have shown that Sprague–Dawley (SD) rats under an intermittent-access two-bottle choice drinking procedure (IE procedure) voluntarily drank high amounts of ethanol. However, an effect of EA on ethanol consumption of the SD rats under this drinking procedure has not been demonstrated. In the present study, we demonstrated that SD rats escalated their ethanol intake and subsequently developed ethanol dependence under the IE procedure. A single low (2 Hz), but not high frequency (100 Hz) EA treatment applied at the bilateral acupoint Zusanli (ST36), but not at the tail reduced voluntary intake of, and preference for ethanol, but not sucrose. Furthermore, repeated EA treatments decreased the intake of and preference for ethanol, without resulting in a rebound increase in ethanol intake when the EA treatments were terminated. These observations indicate that EA may be a useful treatment for alcohol abuse.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Low frequency electroacupuncture selectively decreases voluntarily ethanol intake in rats

Zou

2011

Brain Research Bulletin

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“…Acupuncture therapy has been used for many types of neuronal disorders as well as for pain control in oriental medicine. The beneficial effects of acupuncture on psychological parameters have recently been emphasized in various experiments in both animals and humans (Yano et al 1993;Han et al 1999;Yoshimoto et al 2001).…”

mentioning

confidence: 99%

Acupuncture Stimulates the Release of Serotonin, but Not Dopamine, in the Rat Nucleus Accumbens

Yoshimoto

Fukuda

Hori

et al. 2006

Tohoku J. Exp. Med.

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Acupuncture has been introduced as one of the available therapies widely used in alternative medicine, but it has not achieved widespread acceptance with scientific evidence. Furthermore there are still many unanswered questions about the basic mechanisms of acupuncture. To investigate the neuropharmacological mechanisms of oriental acupuncture, we studied the acupuncture-induced changes of in vivo monoamine release in the rat brain. A microdialysis guide cannula was implanted into the nucleus accumbens (ACC), which plays an important role in the brain reward system. Acupuncture treatment at the unilateral or bilateral Shenshu (bladder urinary channel 23) acupoints, located on the both sides of the spinous processes on the lower back, was carried out for 60 min in freely moving rats, and the dopamine (DA) and serotonin (5-HT) contents of the microdialysates in the ACC were measured simultaneously. In rats subjected to acupuncture at bilateral Shenshu acupoints, increases of 5-HT release in the ACC were observed at 20 min of acupuncture treatment and continued until 40 min after acupuncture was ended. Acupuncture at a unilateral Shenshu acupoint increased the release of 5-HT at 20 min compared with that in the sham-control group. Five-HT release returned to the baseline level at 120 min. The effects of acupuncture at bilateral Shenshu acupoints on the release of 5-HT in the ACC were greater than that of unilateral acupuncture treatment. In contrast, DA release in the ACC was not changed following acupuncture treatment. Effective acupuncture increased and prolonged the activity of serotonergic neurons in the reward system pathway of the brain. This suggests that oriental acupuncture therapy may be effective for the treatment of emotional disorders, drug abuse and alcoholism.

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“…Compared with the currently available pharmacological interventions, a clear advantage of acupuncture therapy is that it has the potential to help drug abusers stay away from drugs without major adverse side effects [13]. Previous clinical and preclinical studies have shown that acupuncture or acupuncture combined with electrical stimulation (electroacupuncture, EA) is an effective treatment for alcohol withdrawal syndrome and alcohol abuse [129,130,131,132,133,134,13].…”

Section: Treatment Of Alcoholismmentioning

confidence: 99%

Impacts of Alcoholism in Public Health: A Systematic Review

Pinheiro¹,

Alencar²,

Pimentel³

et al. 2015

Int Arch Med

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Electroacupuncture Stimulation Suppresses the Increase in Alcohol-Drinking Behavior in Restricted Rats

Cited by 19 publications

References 15 publications

Low frequency electroacupuncture selectively decreases voluntarily ethanol intake in rats

Low frequency electroacupuncture selectively decreases voluntarily ethanol intake in rats

Acupuncture Stimulates the Release of Serotonin, but Not Dopamine, in the Rat Nucleus Accumbens

Impacts of Alcoholism in Public Health: A Systematic Review

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