Low frequency electroacupuncture selectively decreases voluntarily ethanol intake in rats

Li, Jing; Zou, Yihuai; Ye, Jiang-Hong

doi:10.1016/j.brainresbull.2011.08.013

Cited by 25 publications

(33 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have previously shown that SD rats in the IE2BC paradigm escalated their ethanol intake and subsequently became putatively dependent on ethanol (J Li et al, 2011a, 2011b). In the current study, we used SD rats for electrophysiological experiments to take the advantage of their calmness and ease of handling.…”

Section: Methodsmentioning

confidence: 99%

High Frequency Electrical Stimulation of Lateral Habenula Reduces Voluntary Ethanol Consumption in Rats

Zuo

et al. 2016

IJNPPY

Self Cite

View full text Add to dashboard Cite

Background:Development of new strategies that can effectively prevent and/or treat alcohol use disorders is of paramount importance, because the currently available treatments are inadequate. Increasing evidence indicates that the lateral habenula (LHb) plays an important role in aversion, drug abuse, and depression. In light of the success of high-frequency stimulation (HFS) of the LHb in improving helplessness behavior in rodents, we assessed the effects of LHb HFS on ethanol-drinking behavior in rats.Methods:We trained rats to drink ethanol under an intermittent access two-bottle choice procedure. We used c-Fos immunohistochemistry and electrophysiological approaches to examine LHb activity. We applied a HFS protocol that has proven effective for reducing helplessness behavior in rats via a bipolar electrode implanted into the LHb.Results:c-Fos protein expression and the frequency of both spontaneous action potential firings and spontaneous excitatory postsynaptic currents were higher in LHb neurons of ethanol-withdrawn rats compared to their ethanol-naïve counterparts. HFS to the LHb produced long-term reduction of intake and preference for ethanol, without altering locomotor activity. Conversely, low-frequency electrical stimulation to the LHb or HFS applied to the nearby nucleus did not affect drinking behavior.Conclusions:Our results suggest that withdrawal from chronic ethanol exposure increases glutamate release and the activity of LHb neurons, and that functional inhibition of the LHb via HFS reduces ethanol consumption. Thus, LHb HFS could be a potential new therapeutic option for alcoholics.

show abstract

Section: Methodsmentioning

confidence: 99%

High Frequency Electrical Stimulation of Lateral Habenula Reduces Voluntary Ethanol Consumption in Rats

Zuo

et al. 2016

IJNPPY

Self Cite

View full text Add to dashboard Cite

show abstract

“…Blood alcohol content was not assessed in these rats to avoid the association of ethanol with the potentially aversive experience of a needle-stick to withdraw blood. Previous citations have shown that the EOD drinking method achieves blood alcohol levels in the range of 5–80 mg/dL in Sprague-Dawley rats, and that intake correlates well with blood alcohol level (Li et al 2011). Another study with Sprague-Dawley rats has similarly demonstrated that intake is related to BEC (higher intake associated with higher BEC) (Vetter-O’Hagen and Spear 2011).…”

Section: Methodsmentioning

confidence: 99%

Effect of sex on ethanol consumption and conditioned taste aversion in adolescent and adult rats

et al. 2013

View full text Add to dashboard Cite

Rationale Vulnerability to alcoholism is determined by many factors, including the balance of pleasurable vs. aversive alcohol-induced sensations: pleasurable sensations increase drinking, aversive sensations reduce it. Both female sex and adolescent age are associated with fewer use-limiting effects of ethanol and more rapid development of alcohol abuse. Objectives This study assessed voluntary drinking and the aversive effects of alcohol in adolescent and adult male and female rats, to determine whether these measures are inversely related across the sexes and development. Methods Voluntary drinking of 20% ethanol in an every-other-day (EOD) availability pattern and the full dose-response relationship of ethanol CTA were assessed in male and female adolescent and adult rats. Results CTA was sex-specific in adult but not adolescent rats, with adult females exhibiting less aversion. Voluntary ethanol consumption varied according to age and interindividual differences in consumption patterns but was not sex-specific. Adolescents initially drank more than adults, exhibited greater day-to-day variation in consumption, were more susceptible to the alcohol deprivation effect, and took longer to establish individual differences in consumption patterns. Conclusions These results show that the evolution of drinking patterns differs in adolescents and adults. While a small cohort of adults establish high consumption patterns quickly, most adolescents drink at high levels initially and show marked deprivation-induced increases, but a significant percentage reduce intake as they become adult. High drinking adolescents do not ramp up like adults, but maintain adolescent drinking patterns into adulthood. Sex differences were not observed in EOD drinking during either adolescence or adulthood.

show abstract

“…However, some studies used Sprague-Dawley (Bito-Onon, Simms, Chatterjee, Holgate, & Bartlett, 2011; Li, Zou, & Ye, 2011) or alcohol-preferring (P or Sardinian) rats (Sabino, Kwak, Rice, & Cottone, 2013; Simms et al, 2008). Simms and colleagues (2008) compared ethanol drinking in Wistar, Long-Evans, and alcohol-preferring (P) rats, and found similar intake levels in Long-Evans (5.1 ± 0.6 g/kg/24 h) and Wistar rats (5.8 ± 0.8 g/kg/24 h).…”

Section: Intermittent Access To 20% Alcohol In 2-bottle Choicementioning

confidence: 99%

Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse

Carnicella

Ron

Barak

2014

Alcohol

271

295

View full text Add to dashboard Cite

One of the major challenges in preclinical studies of alcohol abuse and dependence remains the development of paradigms that will elicit high ethanol intake and mimic the progressive transition from low or moderate social drinking to excessive alcohol consumption. Exposure of outbred rats to repeated cycles of free-choice ethanol intake and withdrawal with the use of intermittent access to 20% ethanol in a 2-bottle choice procedure (IA2BC) has been shown to induce a gradual escalation of voluntary ethanol intake and preference, eventually reaching ethanol consumption levels of 5–6 g/kg/24 h, and inducing pharmacologically relevant blood ethanol concentrations (BECs). This procedure has recently been gaining popularity due to its simplicity, high validity, and reliable outcomes. Here we review experimental and methodological data related to IA2BC, and discuss the usefulness and advantages of this procedure as a valuable pre-training method for initiating operant ethanol self-administration of high ethanol intake, as well as conditioned place preference (CPP). Despite some limitations, we provide evidence that IA2BC and related operant procedures provide the possibility to operationalize multiple aspects of alcohol abuse and addiction in a rat model, including transition from social-like drinking to excessive alcohol consumption, binge drinking, alcohol seeking, relapse, and neuroadaptations related to excessive alcohol intake. Hence, IA2BC appears to be a useful and relevant procedure for preclinical evaluation of potential therapeutic approaches against alcohol abuse disorders.

show abstract

Low frequency electroacupuncture selectively decreases voluntarily ethanol intake in rats

Cited by 25 publications

References 43 publications

High Frequency Electrical Stimulation of Lateral Habenula Reduces Voluntary Ethanol Consumption in Rats

High Frequency Electrical Stimulation of Lateral Habenula Reduces Voluntary Ethanol Consumption in Rats

Effect of sex on ethanol consumption and conditioned taste aversion in adolescent and adult rats

Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse

Contact Info

Product

Resources

About