Electroactive Polymeric Biomaterials

Povlich, Laura K.; Feldman, Kathleen E.; Shim, Bong Sup; Martin, David C.

doi:10.1016/b978-0-08-055294-1.00042-8

Cited by 8 publications

(3 citation statements)

References 131 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its high surface area and unique structures resulted in lower impedance which enhance its usage in bioelectrode coatings. In vitro toxicity and biocompatibility tests have shown that PEDOT, like PPy, has no cytotoxic effects on cells [85]. Xufeng Niu and Mahmoud Rouabhia showed that a sorely thin coating of PEDOT on micro fibrous PLA network is of adequate conductivity and durability in hydrous milieu to maintain ES to cultured fibroblasts.…”

Section: Conductive Materials In Tissue Engineeringmentioning

confidence: 99%

Electrically Conductive Materials: Opportunities and Challenges in Tissue Engineering

et al. 2019

View full text Add to dashboard Cite

Tissue engineering endeavors to regenerate tissues and organs through appropriate cellular and molecular interactions at biological interfaces. To this aim, bio-mimicking scaffolds have been designed and practiced to regenerate and repair dysfunctional tissues by modifying cellular activity. Cellular activity and intracellular signaling are performances given to a tissue as a result of the function of elaborated electrically conductive materials. In some cases, conductive materials have exhibited antibacterial properties; moreover, such materials can be utilized for on-demand drug release. Various types of materials ranging from polymers to ceramics and metals have been utilized as parts of conductive tissue engineering scaffolds, having conductivity assortments from a range of semi-conductive to conductive. The cellular and molecular activity can also be affected by the microstructure; therefore, the fabrication methods should be evaluated along with an appropriate selection of conductive materials. This review aims to address the research progress toward the use of electrically conductive materials for the modulation of cellular response at the material-tissue interface for tissue engineering applications.

show abstract

Section: Conductive Materials In Tissue Engineeringmentioning

confidence: 99%

Electrically Conductive Materials: Opportunities and Challenges in Tissue Engineering

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In contrast to PPy, PEDOT can also preserve 89% of its conductivity under the same experimental conditions while displaying no-cytotoxic effects at higher concentrations. 125,126 Niu et al showed that a thin coating of PEDOT on a micro fibrous PLA network was enough to provide good conductivity to the scaffolds for their stimulation on using an external electrical field. Further, PEDOT-coating on the PLA fibers resulted in enhanced durability, higher hydrophilicity, thermal stability, and lower glass transition temperature in comparison to pristine PLA microfibers.…”

Section: Electrically Conductive Polymersmentioning

confidence: 99%

Recent advances in tailoring stimuli-responsive hybrid scaffolds for cardiac tissue engineering and allied applications

Mehrotra,

Dey,

Sachdeva

et al. 2023

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

“…72 Two early examples include a study of the bioelectrocatalysed reduction of nitrate utilizing polythiophene bipyridium enzymes, 73 was noted that the electrostability/activity was decreased in the composite films, the films showed slightly increased performance with respect to cell growth and proliferation. 82 One example is the carboxylic-acid substituted EDOT monomer (EDOT-acid). 82 One example is the carboxylic-acid substituted EDOT monomer (EDOT-acid).…”

Section: Biofunctionalization Of Polydioxythiophenes Prepared By Elecmentioning

confidence: 99%

Biofunctionalization of polydioxythiophene derivatives for biomedical applications

et al. 2016

View full text Add to dashboard Cite

The polydioxythiophenes PEDOT and more recently ProDOT have emerged as champion materials in the field of organic bioelectronics, both in the domain of biosensing and also for integration with living cells (both in vitro and in vivo). Although polydioxythiophenes in their pristine forms have shown great promise for bioelectronics, in order to broaden the spectrum of applications, a biofunctionalization step is essential. In this review we summarise the methods that have been used thus far to biofunctionalize polydioxythiophenes in an effort to improve the biotic/abiotic interface. We provide an introduction to this class of materials, focusing particularly on the different methods of synthesis (chemical oxidative polymerization, vapor phase polymerization or direct electrochemical polymerization) and discuss the implications of synthesis on biofunctionalization. Rather than provide an exhaustive review, we chose to highlight key examples of biofunctionalization techniques for polydioxythiophenes for specific biomedical applications. Finally, we conclude with a brief discussion of the importance of biofunctionalization methods in future bioelectronics applications, and some ideas for future directions in this field. Figure 1: Structures of polydioxythiophene monomers and dopants. a) structure of EDOT monomer and modified EDOT with different pendant groups (carboxyl shown). b) structure of ProDOT monomer and modified ProDOT with different pendant groups (ProDOT-ene shown) c) Usual dopants such as polystyrene sulfonate (PSS) polymer, tosylate (TOS) monomer, and perchlorate monomer CPs came to the forefront in 1976 with research done by Alan MacDiarmid, Hideki Shirakawa and Alan Heeger, and have since been shown to display many desirable characteristics for a variety of applications. 3,4 An important example is their mixed conductivity; In CPs, electrons move primarily along the conjugated backbone of the polymer, but charge hopping between chains also occurs. CPs typically have an open microstructure that allows for facile ionic transport. This mixed (electronic and ionic) conductivity has been shown to be very useful for certain biomedical applications. 5 The most frequently used CPs for biomedical applications include polypyrrole, polyaniline and polythiophenes. 6 Although polypyrrole lead

show abstract

Electroactive Polymeric Biomaterials

Cited by 8 publications

References 131 publications

Electrically Conductive Materials: Opportunities and Challenges in Tissue Engineering

Electrically Conductive Materials: Opportunities and Challenges in Tissue Engineering

Recent advances in tailoring stimuli-responsive hybrid scaffolds for cardiac tissue engineering and allied applications

Biofunctionalization of polydioxythiophene derivatives for biomedical applications

Contact Info

Product

Resources

About