Recent advances in tailoring stimuli-responsive hybrid scaffolds for cardiac tissue engineering and allied applications

Mehrotra, Shreya; Dey, Souradeep; Sachdeva, Kunj; Mohanty, Sujata; Mandal, Biman B.

doi:10.1039/d3tb00450c

Cited by 4 publications

(1 citation statement)

References 261 publications

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“…SF-based matrices have been fabricated to engineer tissues like bone, cartilage, blood vessels, meniscus, heart, intervertebral discs, liver and skin for accessing the in vitro and in vivo tissue-specific responses [21,79,83,84,86,91,92,[94][95][96][97][98][99][100][101][102] (figure 2). SF-based matrices have been extensively evaluated for cartilage regeneration.…”

Section: Silk As a Biomaterialsmentioning

confidence: 99%

Trends and advances in silk based 3D printing/bioprinting towards cartilage tissue engineering and regeneration

Singh,

Bandyopadhyay,

Dey

et al. 2024

Prog. Biomed. Eng.

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Cartilage repair remains a significant clinical challenge in orthopedics due to its limited self- regeneration potential and often progresses to osteoarthritis which reduces the quality of life. 3D printing/bioprinting has received vast attention in biofabrication of functional tissue substitutes due to its ability to develop complex structures such as zonally structured cartilage and osteochondral tissue as per patient specifications with precise biomimetic control. Towards a suitable bioink development for 3D printing/bioprinting, silk fibroin has garnered much attention due to its advantageous characteristics such as shear thinning behavior, cytocompatibility, good printability, structural fidelity, affordability, and ease of availability and processing. This review attempts to provide an overview of current trends/strategies and recent advancements in utilizing silk-based bioinks/biomaterial-inks for cartilage bioprinting. Herein, the development of silk-based bioinks/biomaterial-inks, its components and the associated challenges, along with different bioprinting techniques have been elaborated and reviewed. Furthermore, the applications of silk-based bioinks/biomaterial-inks in cartilage repair followed by challenges and future directions are discussed towards its clinical translations and production of next-generation biological implants.

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Section: Silk As a Biomaterialsmentioning

confidence: 99%

Trends and advances in silk based 3D printing/bioprinting towards cartilage tissue engineering and regeneration

Singh,

Bandyopadhyay,

Dey

et al. 2024

Prog. Biomed. Eng.

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Current multi-scale biomaterials for tissue regeneration following spinal cord injury

Zhang,

Wu,

et al. 2024

Neurochemistry International

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PVDF-Modified Graphene Nanosheets as a Piezoelectric and Electroconductive Bilayer Platform for Cardiac Cell Stimulation

Golafshan,

Nikukar,

Mashayekhan

et al. 2024

ACS Appl. Nano Mater.

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The conductive microenvironment and pulsatile electromechanical cues in the native myocardium tissue regulate biological responses; hence, advanced nanomaterials must be developed to construct cardiac tissue-like constructs. In this work, we present a stretchable, electroconductive, and piezoelectric biphasic layered structure based on bilayer graphene nanolayers (BGF) modified polyvinylidene fluoride (PVDF) nanofibers to provide suitable electrophysiological microenvironments for the modulation of H9c2 embryonic rat cardiomyoblasts toward cardiomyocyte-like phenotypes. High-quality BGFs were synthesized by chemical vapor deposition, and PVDF nanofibrous webs were prepared by electrospinning. We demonstrate that the bilayer graphene nanosheets not only enhance the conductivity and piezoelectricity properties of PVDF nanofibers but also promote cardiomyocyte-like phenotypes by providing nanotopography cues. The BGF/PVDF biphasic layered structure (170 ± 15 μm thickness) provides an electrical conductivity of 2.82 μS/cm and a piezoelectric voltage of 0.47 mV/N, making it a suitable platform for cardiac cell stimulation under pulsatile electrical stimulation. Immunofluorescence staining analysis determines that the mechanism of graphene influence is associated with enhanced structural organization and expression of sarcomeric α-actinin (the cardiac-specific marker for H9c2 cells). Our results indicate that the synergistic effect of electroconductive (graphene) and piezoelectric (PVDF) nanomaterials provides a promising strategy for developing functional cardiac-like tissue substitutes, which can be used as an efficient tool for in vitro cardiac models for drug testing and screening.

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Recent advances in tailoring stimuli-responsive hybrid scaffolds for cardiac tissue engineering and allied applications

Abstract: Deciphering the role of stimuli-responsive materials in modulating surrounding matrix properties, and cardiomyocyte maturation and behaviour resulting in generation of functionally active cardiac tissues.

Cited by 4 publications

References 261 publications

Trends and advances in silk based 3D printing/bioprinting towards cartilage tissue engineering and regeneration

Trends and advances in silk based 3D printing/bioprinting towards cartilage tissue engineering and regeneration

Current multi-scale biomaterials for tissue regeneration following spinal cord injury

PVDF-Modified Graphene Nanosheets as a Piezoelectric and Electroconductive Bilayer Platform for Cardiac Cell Stimulation

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