Electro-responsive polymer-based platforms for electrostimulation of cells

Kanaan, Akel Ferreira; Piedade, Ana P.

doi:10.1039/d1ma01012c

Cited by 12 publications

(5 citation statements)

References 108 publications

(270 reference statements)

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“…This concept can be encapsulated with the term Play the Hand you’re Dealt (PHD): successful developmental systems are primed to operate with whatever internal and external conditions they are faced as they come into the world (within some broad, but limited, range). PHD is why biological systems are highly interoperable with exotic synthetic materials [ 226 ], why huge mechanistic diversity exists within individuals of an evolutionary type [ 227 ], and why viable chimeras can be made at every level (from mixing DNA to cell/tissue grafts, to parabiosis [ 24 ], to hybrots in which brains can be used to drive novel robotic bodies or live entirely in virtual worlds [ 174 ]). This extends to behavior and neuroscience: we are all “brains in a vat”, and our neural systems can readily adapt to sensory–motor augmentation with engineered devices or novel sense organs [ 228 , 229 ] because of the fundamental plasticity that requires each being to learn about its own form and function in real time.…”

Section: Beginner’s Mind: Self-organization On the Fly As The Origin ...mentioning

confidence: 99%

Darwin’s agential materials: evolutionary implications of multiscale competency in developmental biology

Levin

2023

Cell. Mol. Life Sci.

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A critical aspect of evolution is the layer of developmental physiology that operates between the genotype and the anatomical phenotype. While much work has addressed the evolution of developmental mechanisms and the evolvability of specific genetic architectures with emergent complexity, one aspect has not been sufficiently explored: the implications of morphogenetic problem-solving competencies for the evolutionary process itself. The cells that evolution works with are not passive components: rather, they have numerous capabilities for behavior because they derive from ancestral unicellular organisms with rich repertoires. In multicellular organisms, these capabilities must be tamed, and can be exploited, by the evolutionary process. Specifically, biological structures have a multiscale competency architecture where cells, tissues, and organs exhibit regulative plasticity—the ability to adjust to perturbations such as external injury or internal modifications and still accomplish specific adaptive tasks across metabolic, transcriptional, physiological, and anatomical problem spaces. Here, I review examples illustrating how physiological circuits guiding cellular collective behavior impart computational properties to the agential material that serves as substrate for the evolutionary process. I then explore the ways in which the collective intelligence of cells during morphogenesis affect evolution, providing a new perspective on the evolutionary search process. This key feature of the physiological software of life helps explain the remarkable speed and robustness of biological evolution, and sheds new light on the relationship between genomes and functional anatomical phenotypes.

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Section: Beginner’s Mind: Self-organization On the Fly As The Origin ...mentioning

confidence: 99%

Darwin’s agential materials: evolutionary implications of multiscale competency in developmental biology

Levin

2023

Cell. Mol. Life Sci.

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“…This concept can be encapsulated with the term Play the Hand you're Dealt (PHD): successful developmental systems are primed to operate with whatever internal and external conditions they are faced as they come into the world (within some broad, but limited, range). PHD is why biological systems are highly interoperable with exotic synthetic materials [220], why huge mechanistic diversity exists within individuals of an evolutionary type [221], and why viable chimeras can be made at every level (from mixing DNA to cell/tissue grafts to parabiosis [24], to hybrots in which brains can be used to drive novel robotic bodies or live entirely in virtual worlds [170]). This extends to behavior and neuroscience: we are all "brains in a vat", and our neural systems can readily adapt to sensory-motor augmentation with engineered devices or novel sense organs [222,223] because of the fundamental plasticity that requires each being to learn about its own form and function in real-time.…”

Section: Beginner's Mind: Self-organization On the Fly As The Origin ...mentioning

confidence: 99%

Darwin’s Agential Materials: evolutionary implications of multi-scale competency in developmental biology

Levin¹

2023

Preprint

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A critical aspect of evolution is the layer of developmental physiology that operates between the genotype and the anatomical phenotype. While much work has addressed the evolution of developmental mechanisms and the evolvability of specific genetic architectures with emergent complexity, one aspect has not been sufficiently explored: the implications of morphogenetic problem-solving competencies for the evolutionary process itself. The cells that evolution works with are not passive components: rather, they have numerous capabilities for behavior because they derive from ancestral unicellular organisms with rich repertoires. In multicellular organisms, these capabilities must be tamed, and can be exploited, by the evolutionary process. Specifically, biological structures have a multi-scale competency architecture where cells, tissues, and organs exhibit regulative plasticity - the ability to adjust to perturbations such as external injury or internal modifications and still accomplish specific adaptive tasks across metabolic, transcriptional, physiological, and anatomical problem spaces. Here, I review examples illustrating how physiological circuits guiding cellular collective behavior impart computational properties to the agential material that serves as substrate for the evolutionary process. I then explore the ways in which the collective intelligence of cells during morphogenesis affect evolution, providing a new perspective on the evolutionary search process. This key feature of the physiological software of life helps explain the remarkable speed and robustness of biological evolution, and sheds new light on the relationship between genomes and functional anatomical phenotypes.

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“…As such, the biomaterials with appropriate electrical conductivity can serve as implantable materials and devices to augment defective and degenerative tissues, regulating cell-matrix interactions and ultimately improving tissue regeneration [4,22,[33][34][35][36][37][38]. Furthermore, more recently, advanced platforms that can function through external energy, such as light, magnetism, and stress (e.g., employing piezoelectric materials) as well as via biochemical reactions (e.g., glucose) have also been explored to provide electrical signals and promote tissue healing [39][40][41][42].…”

Section: Introductionmentioning

confidence: 99%

Biomaterials-enabled electrical stimulation for tissue healing and regeneration

Kim,

Baby,

Lee

et al. 2024

Med-X

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The electrical microenvironment is considered a pivotal determinant in various pathophysiological processes, including tissue homeostasis and wound healing. Consequently, extensive research endeavors have been directed toward applying electricity to cells and tissues through external force devices or biomaterial-based platforms. In addition to in situ electroconductive matrices, a new class of electroactive biomaterials responsive to stimuli has emerged as a focal point of interest. These electroactive materials, in response to intrinsic biochemical (e.g., glucose) or external physical stimuli (e.g., light, magnetism, stress), hold significant potential for cell stimulation and tissue regeneration. In this communication, we underscore this distinct category of electroactive biomaterials, discussing the currently developed biomaterial platforms and their biological roles in stimulating cells and tissues during the healing and regeneration process. We also critically evaluate the inherent limitations and challenges of these biomaterials while offering forward-looking insights into their promise for future clinical translations. Graphical Abstract

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Electro-responsive polymer-based platforms for electrostimulation of cells

Abstract: Tissue engineering is a fascinating branch of science that aims to develop strategies to respond to tissue/organ damage with the slightest biological rejection. It is currently known that electric cues...

Cited by 12 publications

References 108 publications

Darwin’s agential materials: evolutionary implications of multiscale competency in developmental biology

Darwin’s agential materials: evolutionary implications of multiscale competency in developmental biology

Darwin’s Agential Materials: evolutionary implications of multi-scale competency in developmental biology

Biomaterials-enabled electrical stimulation for tissue healing and regeneration

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