Electro-Encephalographic and Blood Gas Observations in Human Surgical Patients During Xenon Anesthesia

Morris, Lucien E.; Knott, John R.; Pittinger, Charles B.

doi:10.1097/00000542-195505000-00003

Cited by 46 publications

(12 citation statements)

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“…The mild reaction to altered Paco 2 in baboons may be due to artificial ventilation with nitrous oxide in oxygen and relaxation. The EEG changes with an initial depression of aand /3-wave activity and an increase in slow wave activity have already been noted by Morris et al 26 and Cullen and Gross 27 during xenon anesthesia in humans. Burst suppression was not noted by either them or us, in contrast to experiences with other inhalation anesthetics like ether 14 or cyclopropane.…”

Section: Discussionsupporting

confidence: 57%

Effect of stable xenon in room air on regional cerebral blood flow and electroencephalogram in normal baboons.

Hartmann¹,

Wassman²,

Czernicki³

et al. 1987

Stroke

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Measurement of regional cerebral blood flow (rCBF) was performed in 6 healthy baboons during ventilation with 35% stable xenon in artificial air. rCBF was measured with the intraarterial xenon-133 method. EEG was recorded continuously. All CBF areas of interest over one hemisphere reacted in the same way. Mean flow increased during short-term exposure to stable xenon and decreased if stable xenon inhalation was continued for at least 24 minutes. EEG showed a decrease of a-and /3-wave patterns a short tune after the start of stable xenon inhalation without further changes over the period when rCBF finally decreased. CO 2 reactivity increased in most animals, and autoregulation to mild arterial hypotension was significantly unpaired with increased flow. It is concluded that 35% stable xenon in artificial air increases rCBF after short-term exposure and decreases rCBF after longer exposure. EEG changes were noted after short-term exposure. rCBF and EEG recovered rapidly after the end of stable xenon inhalation. (Stroke 1987; 18:643-648)

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Section: Discussionsupporting

confidence: 57%

Effect of stable xenon in room air on regional cerebral blood flow and electroencephalogram in normal baboons.

Hartmann¹,

Wassman²,

Czernicki³

et al. 1987

Stroke

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“…Meyer et al 9 reported EEG changes if the Xe 1 concentration exceeded 45% and loss of consciousness if the concentration exceeded 60%. Morris et al 20 described EEG slowing and anesthesia at Xe 1 concentrations of 80%. Burst suppression was not seen in our EEG tracings with 35% Xe As regards rCBF changes, we found no significant differences among individual areas of the brain.…”

Section: Resultsmentioning

confidence: 99%

“…However, we know that high concentrations of Xe' may alter consciousness and the electroencephalogram (EEG). 20 - 23 Therefore, many groups use ^35% Xe' in O* which still permits a sufficient increase in Hounsfield units during inhalation to allow calculation of regional cerebral blood flow (rCBF). We previously conducted a study on six baboons that showed that rCBF and EEG were influenced by Xe 5 .…”

mentioning

confidence: 99%

Effect of stable xenon on regional cerebral blood flow and the electroencephalogram in normal volunteers.

Hartmann

Dettmers

Schuier

et al. 1991

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We evaluated the effects of breathing 35% stable xenon in 65% oxygen on regional cerebral blood flow and the electroencephalogram in 20 normal volunteers. We measured blood flow in 32 brain regions over both hemispheres with the xenon-133 intravenous injection technique in two protocols. In the first protocol (n = 10), a baseline study was followed by a second study during 5 minutes of breathing stable xenon; in the other protocol (n=8), the baseline study was followed by a second study after 5 minutes of breathing stable xenon. Two volunteers were excluded due to excessive movements during the inhalation of stable xenon. Some of the remaining 18 volunteers had varying alterations of consciousness accompanied by electroencephalogram changes. After stable xenon inhalation the electroencephalogram returned to normal within 2-3 minutes. During stable xenon inhalation mean±SD PECO 2 dropped significantly from 39.4±4.4 to 33J±5.4 mm Hg in the first protocol and from 39.4±2.6 to 34.8±4.1 mm Hg in the second protocol due to hyperventilation in 13 volunteers. Mean regional cerebral blood flow increased significantly by 13.5-25.4% without correction for PECO 2 . In the first protocol regional cerebral blood flow increased by >L2% in 11-14 (depending on the flow parameter) of the 20 hemispheres. In the second protocol regional cerebral blood flow increased by >12% in 9-13 of the 16 hemispheres. We conclude that cautious interpretation is necessary in the assessment of regional cerebral blood flow with 35% xenon-enhanced computed tomography. {Stroke 1991;22:182-189)

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“…Zur Applikation sind spezielle Narkoseger ä te erforderlich. Ü ber EEG-Ver ä nderungen bei Xenon-Narkosen von Patienten berichteten Morris et al [16] bereits im Jahr 1955. Nach einer initialen Unterdr ü ckung der Alpha-Aktivit ä t und einem niederamplitudigen schnellen Muster im Anfangsstadium der Xenon-Anfl utung folgte ein rhythmisches 5 -7-Hz-Muster, das mit anderen Frequenzen gemischt war.…”

Section: Statistikunclassified

EEG-Stadien im Steady State von Xenon-Narkosen

et al. 2010

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Electro-Encephalographic and Blood Gas Observations in Human Surgical Patients During Xenon Anesthesia

Cited by 46 publications

References 0 publications

Effect of stable xenon in room air on regional cerebral blood flow and electroencephalogram in normal baboons.

Effect of stable xenon in room air on regional cerebral blood flow and electroencephalogram in normal baboons.

Effect of stable xenon on regional cerebral blood flow and the electroencephalogram in normal volunteers.

EEG-Stadien im Steady State von Xenon-Narkosen

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