Effect of stable xenon in room air on regional cerebral blood flow and electroencephalogram in normal baboons.

Hartmann, A.; Wassman, H; Czernicki, Z; Dettmers, C.; Schumacher, H.; Tsuda, Yasuyuki

doi:10.1161/01.str.18.3.643

Cited by 26 publications

(12 citation statements)

References 27 publications

(12 reference statements)

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“…With renewed interest in stable xenon inhalation for CBF measurement, several investigators have reported EEG effects. Hartmann et al, 32 using 35% xenon in baboons, found an increase in slow activity (theta and delta) that is consistent with our results. Two studies in humans breathing 25% and 35% xenon reported an increase in beta 33 and alpha 34 power, respectively.…”

Section: Discussionsupporting

confidence: 93%

Xenon-enhanced computed tomography compared with [14C]iodoantipyrine for normal and low cerebral blood flow states in baboons.

Wolfson

Clark

Greenberg

et al. 1990

Stroke

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Section: Discussionsupporting

confidence: 93%

Xenon-enhanced computed tomography compared with [14C]iodoantipyrine for normal and low cerebral blood flow states in baboons.

Wolfson

Clark

Greenberg

et al. 1990

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“…24 The CO 2 data were recorded continuously by a capnograph, but it should be kept in mind that the reliability of PECO2 as reflecting Paco? decreases with hyperventilation.…”

Section: Resultsmentioning

confidence: 99%

“…We previously conducted a study on six baboons that showed that rCBF and EEG were influenced by Xe 5 . 24 That study prompted us to study the effects of 35% Xe 1 in 65% O 2 on rCBF and EEG in normal volunteers.…”

mentioning

confidence: 99%

Effect of stable xenon on regional cerebral blood flow and the electroencephalogram in normal volunteers.

Hartmann

Dettmers

Schuier

et al. 1991

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We evaluated the effects of breathing 35% stable xenon in 65% oxygen on regional cerebral blood flow and the electroencephalogram in 20 normal volunteers. We measured blood flow in 32 brain regions over both hemispheres with the xenon-133 intravenous injection technique in two protocols. In the first protocol (n = 10), a baseline study was followed by a second study during 5 minutes of breathing stable xenon; in the other protocol (n=8), the baseline study was followed by a second study after 5 minutes of breathing stable xenon. Two volunteers were excluded due to excessive movements during the inhalation of stable xenon. Some of the remaining 18 volunteers had varying alterations of consciousness accompanied by electroencephalogram changes. After stable xenon inhalation the electroencephalogram returned to normal within 2-3 minutes. During stable xenon inhalation mean±SD PECO 2 dropped significantly from 39.4±4.4 to 33J±5.4 mm Hg in the first protocol and from 39.4±2.6 to 34.8±4.1 mm Hg in the second protocol due to hyperventilation in 13 volunteers. Mean regional cerebral blood flow increased significantly by 13.5-25.4% without correction for PECO 2 . In the first protocol regional cerebral blood flow increased by >L2% in 11-14 (depending on the flow parameter) of the 20 hemispheres. In the second protocol regional cerebral blood flow increased by >12% in 9-13 of the 16 hemispheres. We conclude that cautious interpretation is necessary in the assessment of regional cerebral blood flow with 35% xenon-enhanced computed tomography. {Stroke 1991;22:182-189)

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“…These results are at variance with the data of Meyer et al 18 in the baboon, but the discrepancy may be attributable to species. Studies by Hartmann et al 9 in baboons were inconclusive. Recently, they reported 10 a variable response to 35% Xe inhalation for 2.5 and 3.5 minutes in patients with an average increase of about 15%.…”

Section: Discussionmentioning

confidence: 95%

Effect of 33% xenon inhalation on whole-brain blood flow and metabolism in awake and fentanyl-anesthetized monkeys.

Yao

Bandres

Nemoto

et al. 1992

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Background and Purpose: Despite the documented diagnostic value of local cerebral blood flow maps by xenon-enhanced computed tomography, reports of cerebral blood flow activation by inhaled 33% Xe raised concerns about the method's safety and accuracy. We evaluated the effect of 33% Xe inhalation on cerebral blood flow and cerebral metabolic rates for oxygen and glucose in four awake and six fentanyl-anesthetized rhesus monkeys.Methods: Platinum microelectrodes and catheters in the torcular Herophili were used to measure cerebral blood flow by hydrogen clearance, and oxygen and glucose concentrations. Cerebral variables were measured after 5 and 35 minutes of exposure to room air followed randomly by 67% O 2 in 33% N 2 or Xe. Five-and 35-minute measurements were combined because the duration of exposure had no effect Results: In awake monkeys, 33% Xe compared with 33% N 2 reduced (p<0.05) cerebral blood flow from 75±12 to 66±9 (mean±SD) ml -100 g"' • min" 1 and oxygen consumption from 6.1±0.7 to 5.1±0.6 ml • 100 g" 1 • min"

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Effect of stable xenon in room air on regional cerebral blood flow and electroencephalogram in normal baboons.

Cited by 26 publications

References 27 publications

Xenon-enhanced computed tomography compared with [14C]iodoantipyrine for normal and low cerebral blood flow states in baboons.

Xenon-enhanced computed tomography compared with [14C]iodoantipyrine for normal and low cerebral blood flow states in baboons.

Effect of stable xenon on regional cerebral blood flow and the electroencephalogram in normal volunteers.

Effect of 33% xenon inhalation on whole-brain blood flow and metabolism in awake and fentanyl-anesthetized monkeys.

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