Electro-acupuncture ameliorates cognitive impairment via improvement of brain-derived neurotropic factor-mediated hippocampal synaptic plasticity in cerebral ischemia-reperfusion injured rats

Lin, Ren; Li, Xiaojie; Li, Weilin; Chen, Wenlie; Yu, Kunqiang; Zhao, Congkuai; Yang, Shanli; Peng, Hongwei; Tao, Jing; Chen, Lidian

doi:10.3892/etm.2017.4750

Cited by 17 publications

(17 citation statements)

References 36 publications

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“…Acupuncture, as one part of the Traditional Chinese Medicine, has been widely practiced in both Eastern Asia and Western countries for treatment of a variety of diseases, such as depression and traumatic brain injury [22,40]. Studies in animal models demonstrate that EA stimulation exerts neuroprotective effects by inhibiting cell apoptosis and improving synaptic plasticity in cerebral ischemia-reperfusion injury [41,42]. Consistent with these studies, we discovered in the present study that EA stimulation could improve rat motor function recovery after SCI.…”

Section: Discussionsupporting

confidence: 87%

Electroacupuncture ameliorates motor dysfunction via inhibiting p66Shc-mediated oxidative stress and endoplasmic reticulum stress in rats with spinal cord injury

Zhao

Wang

et al. 2020

Preprint

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Background: Spinal cord injury (SCI) is a severe neurological disorder for which there is currently no effective treatment. Electroacupuncture (EA) is a means of combining traditional acupuncture with modern electrotherapy, which has been widely used and verified to have neuroprotective effects. The aim of this study was to evaluate the effects of EA treatment on the repair of SCI and to investigate the possible mechanisms. Methods: Rats were randomly divided into sham, sham+EA, SCI and SCI+EA four groups after SCI model was established. Rat motor function was assessed by the Basso, Beattie and Bresnahan locomotor rating scale, inclined plane test and footprint analysis. Histological alterations were examined with hematoxylin-eosin and Nissl staining. Oxidative stress was evaluated by measuring reactive oxygen species (ROS), glutathione (GSH), total antioxidant capacity (T-AOC), 3-nitrotyrosine (3-NT), as well as 4-hydroxynonenal (4-HNE) levels. The expression of p66Shc and endoplasmic reticulum stress (ERS) were detected to explore the involved mechanisms.Results: EA treatment significantly improved motor functional recovery, reduced spinal cord lesion cavity and neuronal chromatolysis after SCI. Meanwhile, EA treatment alleviated oxidative stress, as indicated by suppression of ROS production, increase in GSH and T-AOC levels and reduction of 3-NT and 4-HNE expression. Further, EA stimulation markedly eliminated the aberrant increase of p66Shc due to SCI in rats. More notably, EA treatment also attenuated ERS via down-regulation of glucose-regulated protein 78, activating transcription factor 4, C/EBP homologous protein, X-box binding protein 1 and activating transcription factor 6 expression in rat spinal cord tissues after SCI. Conclusions: These findings suggest that EA is a potential strategy for treatment of SCI, and the mechanism might be, at least in part, associated with mitigation of p66Shc-mediated oxidative stress and ERS in rats.

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Section: Discussionsupporting

confidence: 87%

Electroacupuncture ameliorates motor dysfunction via inhibiting p66Shc-mediated oxidative stress and endoplasmic reticulum stress in rats with spinal cord injury

Zhao

Wang

et al. 2020

Preprint

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“…Fourty-two articles were included in this meta-analysis, including 30 in English (Wang et al, 2004 , 2015 ; Shao et al, 2008 ; Wei et al, 2011 ; Zhao et al, 2011 ; Zhu et al, 2012 , 2013 , 2018 ; Feng et al, 2013 ; Yang et al, 2014 , 2018b , 2020 ; Zhang et al, 2014 ; Li et al, 2015 , 2016 ; Han et al, 2017 ; Lin et al, 2017 ; Liu et al, 2017 ; Ye et al, 2017b ; Du et al, 2018 ; He et al, 2018 ; Su et al, 2019 ; Ma et al, 2020 ; Wang L. et al, 2020 ; Wang Z. et al, 2020 ; Zheng et al, 2020 ; Cao et al, 2021 ; Pan et al, 2021 ; Wang H. L. et al, 2021 ; Bu et al, 2022 ) and 12 in Chinese (Li and Lai, 2007 ; Lin and Wang, 2008 ; Niu et al, 2009 ; Tian et al, 2015 ; Jiang et al, 2017 ; Zhang et al, 2017 ; Yang et al, 2019 ; Gao et al, 2020 ; Guo et al, 2020 ; Li et al, 2021 ; Chen et al, 2022 ; Xu and Zhang, 2022 ). The publication year of the article was from June 2004 to April 2022.…”

Section: Resultsmentioning

confidence: 99%

“…Methods of surgical modeling: There are 4 surgical modeling methods involved in this study, including 23 articles in the literature using bilateral common carotid artery occlusion (2VO) (Lin and Wang, 2008 ; Wei et al, 2011 ; Zhu et al, 2012 , 2013 , 2018 ; Yang et al, 2014 , 2018b , 2019 , 2020 ; Wang et al, 2015 ; Li et al, 2016 , 2021 ; Han et al, 2017 ; Ye et al, 2017b ; Gao et al, 2020 ; Guo et al, 2020 ; Ma et al, 2020 ; Wang L. et al, 2020 ; Cao et al, 2021 ; Pan et al, 2021 ; Chen et al, 2022 ; Xu and Zhang, 2022 ), 8 articles in the literature using 4-vessel occlusion (4VO) (Wang et al, 2004 ; Li and Lai, 2007 ; Shao et al, 2008 ; Niu et al, 2009 ; Tian et al, 2015 ; Jiang et al, 2017 ; Zhang et al, 2017 ; Bu et al, 2022 ), 3 articles in the literature using embolic occlusion (EO) (Zhao et al, 2011 ; Zhang et al, 2014 ; Li et al, 2015 ), and 8 articles in the literature using middle cerebral artery occlusion (MCAO) (Feng et al, 2013 ; Lin et al, 2017 ; Liu et al, 2017 ; He et al, 2018 ; Su et al, 2019 ; Wang Z. et al, 2020 ; Zheng et al, 2020 ; Wang H. L. et al, 2021 ). Among them, 24 articles clearly stated the total number of the models and the number of successful models (Wang et al, 2004 ; Li and Lai, 2007 ; Lin and Wang, 2008 ; Shao et al, 2008 ; Wei et al, 2011 ; Feng et al, 2013 ; Zhu et al, 2013 ; Li et al, 2016 , 2021 ; Han et al, 2017 ; Jiang et al, 2017 ; Lin et al, …”

Section: Resultsmentioning

confidence: 99%

“…Outcomes: All literatures have escape latency as an important outcome in the water maze, of which 23 included the number of original platform crossings (Wang et al, 2004 ; Li and Lai, 2007 ; Shao et al, 2008 ; Niu et al, 2009 ; Wei et al, 2011 ; Feng et al, 2013 ; Zhang et al, 2014 , 2017 ; Tian et al, 2015 ; Jiang et al, 2017 ; Lin et al, 2017 ; Liu et al, 2017 ; He et al, 2018 ; Su et al, 2019 ; Yang et al, 2019 ; Gao et al, 2020 ; Guo et al, 2020 ; Ma et al, 2020 ; Wang Z. et al, 2020 ; Pan et al, 2021 ; Wang H. L. et al, 2021 ; Bu et al, 2022 ; Xu and Zhang, 2022 ), 11 literatures (Lin and Wang, 2008 ; Li et al, 2016 ; Han et al, 2017 ; Ye et al, 2017b ; Zhu et al, 2018 ; Ma et al, 2020 ; Yang et al, 2020 ; Zheng et al, 2020 ; Cao et al, 2021 ; Pan et al, 2021 ; Xu and Zhang, 2022 ) calculated the time spent in target quadrant, and 7 literatures (Li et al, 2015 ; Wang et al, 2015 ; Liu et al, 2017 ; Yang et al, 2018b , 2020 ; Wang L. et al, 2020 ; Wang Z. et al, 2020 ) calculated the swimming speed.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of acupuncture in animal models of vascular dementia: A systematic review and network meta-analysis

Shi

Zhang

et al. 2022

Front. Aging Neurosci.

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Background and purposeAcupuncture is widely used in clinical practice for the treatment of vascular diseases. However, the protocol, efficacy, and mechanism of acupuncture in animal models of vascular dementia are still controversial. Based on the above problems, we initiated this comprehensive study.MethodsTo analyze the literatures included in this study, 4 databases were searched and the SYRCLE's Risk of bias tool was employed. To perform the subgroup analysis of different acupuncture methods and the Review Manager 5.3 was applied. Meanwhile, the pairwise and network meta-analysis were conducted using Addis 1.16.8. The outcomes included escape latency, number of crossings, time spent in the target quadrant, and swimming speed.ResultsForty-two studies with a total of 1,486 animals were included in this meta-analysis. According to the results from subgroup analysis, GV20 + ST36 (Baihui + bilateral Zusanli) combined with 14-day manual acupuncture can obtain best improvement of the rats cognitive function among all acupuncture regimens (MD: −23.41; 95%CI: −26.66, −20.15; I2 = 0%; P < 0.001). The heterogeneity of other acupuncture treatments was significantly higher than that of GV20 + ST36, because the treatment courses were not uniform. Pair-wise and network comparisons are highly consistent. The major results of the network meta-analysis were as follows, In comparison to the impaired group, the acupuncture group showed significantly reduced escape latency (MD: −25.87; 95%CI: −30.75, −21.12), increased number of original platform crossings (MD: 2.63; 95%CI: 1.94, 3.34) and time spent in the target quadrant (MD: 7.88; 95%CI: 4.25, 11.44). The overall results of the network meta-analysis are as follows: the normal and sham-operated groups performed the best, followed by medicine and acupuncture, while no effect was found in the impaired group treated with non-acupoint and palliative.ConclusionsAcupuncture significantly improves cognitive function in rats with vascular dementia. Compared to other acupuncture plans, (GV20 + ST36, MA) and 14 -day manual acupuncture can be used to obtain better results. The main mechanism of acupuncture in the treatment of vascular dementia is reduced oxidative stress, neuronal inflammation, and apoptosis, as well as the increased synaptic plasticity and neurotransmitters.Systematic review registrationhttps://inplasy.com/inplasy-2021-11-0036/, identifier: INPLASY2021110036.

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“…For instance, Liu et al showed that MCAO/R surgery could induce rat neurological deficits, increase rat escape latency time, and reduce the frequency of rat crossing over the platform location partially by promoting cerebral cortex cell apoptosis, while these effects were noticeably alleviated after EA treatment at the GV20 and GV24 acupoints (19). EA stimulation at the GV20 and GV24 acupoints led to a notable reduction in rat neurological deficit scores, cerebral infarct volume, and escape latency time and a marked increase in hippocampal synaptic plasticity and the number of times the rats passed through the platform area by facilitating the expression of the brain-derived neurotrophic factor (22). However, these studies mainly focused on the roles and certain molecular mechanisms of EA at the GV20 and GV24 acupoints in the MCAO/R model.…”

Section: Introductionmentioning

confidence: 94%

Electroacupuncture of Baihui and Shenting ameliorates cognitive deficits via Pten/Akt pathway in a rat cerebral ischemia injury model

Hao

et al. 2022

Front. Neurol.

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Cerebral ischemic stroke is a huge threat to the health and life of many people. Electroacupuncture (EA) at Baihui (GV20) and Shenting (GV24) acupoints can notably alleviate cerebral ischemia/reperfusion injury (CIRI). However, the molecular basis underlying the effectiveness of EA at the GV20 and GV24 acupoints for CIRI remains largely unknown. Our present study demonstrated that EA treatment at the GV20 and GV24 acupoints markedly alleviated middle cerebral artery occlusion/reperfusion (MCAO/R)-induced cognitive deficits and cerebral infarction in rats. Proteomics analysis revealed that 195 and 218 proteins were dysregulated in rat hippocampal tissues in the MCAO/R vs. sham group and thhhe EA vs. MCAO/R group, respectively. Moreover, 62 proteins with converse alteration trends in MCAO/R vs. sham and EA vs. MCAO/R groups were identified. These proteins might be implicated in the EA-mediated protective effect against MCAO/R-induced cerebral injury. GO enrichment analysis showed that 39 dysregulated proteins in the MCAO/R vs. sham group and 40 dysregulated proteins in the EA vs. MCAO/R group were related to brain and nerve development. Protein–protein interaction analysis of the abovementioned dysregulated proteins associated with brain and nerve development suggested that Pten/Akt pathway-related proteins might play major roles in regulating EA-mediated protective effects against MCAO/R-induced brain and nerve injury. Western blot assays demonstrated that Pak4, Akt3, and Efnb2 were expressed at low levels in the MCAO/R group vs. the sham group but at high levels in the EA group vs. the MCAO/R group. In conclusion, multiple proteins related to the protective effect of EA at the GV20 and GV24 acupoints against CIRI were identified in our study.

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Electro-acupuncture ameliorates cognitive impairment via improvement of brain-derived neurotropic factor-mediated hippocampal synaptic plasticity in cerebral ischemia-reperfusion injured rats

Cited by 17 publications

References 36 publications

Electroacupuncture ameliorates motor dysfunction via inhibiting p66Shc-mediated oxidative stress and endoplasmic reticulum stress in rats with spinal cord injury

Electroacupuncture ameliorates motor dysfunction via inhibiting p66Shc-mediated oxidative stress and endoplasmic reticulum stress in rats with spinal cord injury

Efficacy of acupuncture in animal models of vascular dementia: A systematic review and network meta-analysis

Electroacupuncture of Baihui and Shenting ameliorates cognitive deficits via Pten/Akt pathway in a rat cerebral ischemia injury model

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