Electricity and colloidal stability: How charge distribution in the tissue can affects wound healing

Farber, Paulo Luiz; Hochman, Bernardo; Furtado, Fabianne; Ferreira, Lydia Masako

doi:10.1016/j.mehy.2013.11.038

Cited by 13 publications

(11 citation statements)

References 49 publications

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“…The zeta potential of hydrogels is also a very important parameter in biological fluids of acute wounds. The electrical charge of skin continually changes, as the skin pH isn't stable at the contact with injured tissue . Thus, the change in zeta potential at different pH conditions for the prepared hydrogels were investigated.…”

Section: Resultsmentioning

confidence: 99%

p(AAm/TA)‐based IPN hydrogel films with antimicrobial and antioxidant properties for biomedical applications

Şahiner

Sagbas

Bitlisli

2015

J of Applied Polymer Sci

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Interpenetrating polymer networks (IPN), either semi-IPN (s-IPN) or full IPN, based on a natural polymer tannic acid (TA) and synthetic poly(acrylamide) (p(AAm)) were prepared by incorporation of TA during p(AAm) hydrogel film preparation with and without crosslinking of TA simultaneously. The synthesis of p(AAm/TA) s-IPN and IPN hydrogels with different amounts of TA were prepared by concurrent use of redox polymerization and epoxy crosslinking. The p(AAm)-based hydrogels were completely degraded at 37.5 C within 9 and 2 days at pHs 7.4 and 9, respectively. Biocompatibility of p(AAm), s-IPN, and IPN were tested with WST assay and double staining, they had 75% cell viability up to almost 20 lg mL 21 concentration against L929 fibroblast cell. Antioxidant properties of IPN and s-IPN hydrogels were investigated with FC and ABTS 2 methods. Antimicrobial properties of TAcontaining s-IPN, and IPN hydrogels were determined against three common bacterial strains, Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 6538, and Bacillus subtilis ATCC 6633, and it was found that p(AAm/TA)-based s-IPN and IPN hydrogels are effective antimicrobial and antioxidant materials. Moreover, almost up to day-long linear TA release profiles were obtained from IPN and s-IPN hydrogels in phosphate buffer solution at pH 7.4 at 37.5 C.

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Section: Resultsmentioning

confidence: 99%

p(AAm/TA)‐based IPN hydrogel films with antimicrobial and antioxidant properties for biomedical applications

Şahiner

Sagbas

Bitlisli

2015

J of Applied Polymer Sci

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“…towards the suture, within the first 3 hours of recovery. This is not too dissimilar to the natural process of wound healing, in which breaking down the epithelial barrier leads to a flow of positive charge from surrounding tissues towards the wound centre, thereby triggering the accumulation of cells to initiate the wound healing process [24,30]. In contrast with the prestressed suture samples, the control, annealed and as-packaged equivalents all show notably lower meandering index values, indicating that cell movements were more randomly orientated; i.e.…”

Section: Cell Motilitymentioning

confidence: 88%

“…A recent investigation involving the observation of water droplets on nylon monofilaments and fibres has indicated reduced hydrophobicity as a result of viscoelastic recovery effects [22,23]. This provides some evidence of the electric charge phenomenon; moreover, it is recognised that the presence of electric charges is of fundamental importance in biological processes, including wound healing [24]. Therefore, in addition to the purely mechanical aspects of VIM, a viscoelastically recovering suture may, through a progressive release of electric charges, provide further benefits to the wound healing process by influencing cell motility and migration.…”

Section: Strain εI εE εC (T)mentioning

confidence: 99%

Viscoelastically active sutures – A stitch in time?

Fancey

2021

Materials Science and Engineering: C

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“…Moreover, the positively charged pDADMAC brushes could help attract negatively charged epidermis cells and thus promote cell crawling and proliferation. [ 15 ] Therefore, our BCD/PDA/PAM hydrogels have superior mechanical behaviors with high tensile strength (21–51 kPa), large tensile strain (899–1047%) and ideal compressive performance, and demonstrate stable covering, little displacement, long‐lasting antibacteria and fast wound healing.…”

Section: Introductionmentioning

confidence: 99%

Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing

et al. 2021

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Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21–51 kPa), large tensile strain (899–1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long‐lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long‐lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing.

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Electricity and colloidal stability: How charge distribution in the tissue can affects wound healing

Cited by 13 publications

References 49 publications

p(AAm/TA)‐based IPN hydrogel films with antimicrobial and antioxidant properties for biomedical applications

p(AAm/TA)‐based IPN hydrogel films with antimicrobial and antioxidant properties for biomedical applications

Viscoelastically active sutures – A stitch in time?

Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing

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