Electrically-responsive core-shell hybrid microfibers for controlled drug release and cell culture

Chen, Chuntao; Chen, Xiao; Zhang, Heng; Zhang, Qi; Wang, Li; Li, Chenxi; Dai, Beibei; Yang, Jiazhi; Liu, Jian; Sun, Dongping

doi:10.1016/j.actbio.2017.04.005

Cited by 71 publications

(52 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the development of dermal patches, the porosity of BC is easily exploited to load drugs with different features, ranging from antibacterial activity to anticancer properties . Additionally, BC can be further optimized by chemical modifications with other (bio)polymers or by producing BC‐based materials, to better control its cargo release, burst, or sustained release, and even responsive releases to pH, temperature, or electromagnetism . For the development of oral formulations, BC has been used in combination with other biopolymers for a controlled release of the drug within, e.g., for the oral delivery of insulin, and hydrophobic and hydrophilic drugs alike …”

Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

121

View full text Add to dashboard Cite

Bacterial cellulose (BC) is a nanocellulose form produced by some nonpathogenic bacteria. BC presents unique physical, chemical, and biological properties that make it a very versatile material and has found application in several fields, namely in food industry, cosmetics, and biomedicine. This review overviews the latest state‐of‐the‐art usage of BC on three important areas of the biomedical field, namely delivery systems, wound dressing and healing materials, and tissue engineering for regenerative medicine. BC will be reviewed as a promising biopolymer for the design and development of innovative materials for the mentioned applications. Overall, BC is shown to be an effective and versatile carrier for delivery systems, a safe and multicustomizable patch or graft for wound dressing and healing applications, and a material that can be further tuned to better adjust for each tissue engineering application, by using different methods.

show abstract

Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

121

View full text Add to dashboard Cite

show abstract

“…Among the various nanoscale architectures which can be envisaged, the core-shell arrangement is probably the most fundamental, and has been investigated for potential applications in numerous scientific fields [28][29][30][31]. Methods to fabricate core-shell structures have been very widely explored: a Web of Science with core-shell as the topic conducted on 29 April 2018 resulted in 32,988 hits in the preceding 5 years, equating to 18 publications per day.…”

Section: Introductionmentioning

confidence: 99%

Tunable zero-order drug delivery systems created by modified triaxial electrospinning

Liu

Yang

et al. 2019

Chemical Engineering Journal

137

View full text Add to dashboard Cite

ucture, and in turn its functional performance, is of crucial importance for potential applications. In this study, a new modified triaxial electrospinning process was successfully developed to allow us to precisely tune drug release from nanoscale formulations. In this process, we used two un-electrospinnable liquids as the outer and middle working fluids, with only the core solution being individually electrospinnable into fibers. The outer liquid comprised a mixture of solvents, while the middle fluid was a dilute solution of cellulose acetate (CA). The core fluid was an electrospinnable co-dissolving solution of ferulic acid (FA) and gliadin. By processing these in triaxial electrospinning, we were able to create FA-gliadin fibers coated with a thin but even and continuous coating of CA. The thickness of the CA coating could be precisely varied by adjusting the flow rate of the middle working fluid. The resultant nanofibers have linear and cylindrical morphologies with clear core-shell structures. X-ray diffraction and IR spectroscopy data verified that the fibers comprised amorphous solid dispersions, with intermolecular interactions existing between FA and gliadin. The CA coating eliminated the initial burst release seen with uncoated FA-gliadin fibers, and also led to close to zero-order release profiles which could be incrementally adjusted by varying the thickness of the coating. New process-nanostructure-performance relationships are therefore revealed, and the advanced triaxial electrospinning approach reported in this work has great potential for developing new kinds of functional nanomaterials.

show abstract

“…Research confirmed the attractiveness of this hydrogel for electrically controlled drug delivery applications, including implantable devices and transdermal drug delivery systems. Microand nanotubes of PEDOT were used to load bacterial cellulose [291], PLLA or PLGA [292] (Fig. 8C(2,3)).…”

Section: Drug Delivery Systems Containing Icpsmentioning

confidence: 99%

Conducting Polymers, Hydrogels and Their Composites: Preparation, Properties and Bioapplications

Tomczykowa

Płońska‐Brzezińska

2019

Preprint

View full text Add to dashboard Cite

This review is focused on current state-of-the-art research on electroactive-based materials and their synthesis, as well as their physicochemical and biological properties. Special attention is paid to pristine intrinsically conducting polymers (ICPs) and their composites with other organic and inorganic components, well-defined micro- and nanostructures, and enhanced surface areas compared with those of conventionally prepared ICPs. Hydrogels, due to their defined porous structures and being filled with aqueous solution, offer the ability to increase the amount of immobilized chemical, biological or biochemical molecules. When other components are incorporated into ICPs, the materials form composites; in this particular case, they form conductive composites. The design and synthesis of conductive composites result in the inheritance of the advantages of each component and offer new features because of the synergistic effects between the components. The resulting structures of ICPs, conducting polymer hydrogels and their composites, as well as the unusual physicochemical properties, biocompatibility and multi-functionality of these materials, facilitate their bioapplications. The synergistic effects between constituents have made these materials particularly attractive as sensing elements for biological agents, and they also enable the immobilization of bioreceptors such as enzymes, antigen–antibodies, and nucleic acids onto their surfaces for the detection of an array of biological agents. Currently, these materials have unlimited applicability in biomedicine. In this review, we have limited discussion to three areas in which it seems that the use of ICPs and materials, including their different forms, are particularly interesting, namely, biosensors, delivery of drugs and tissue engineering.

show abstract

Electrically-responsive core-shell hybrid microfibers for controlled drug release and cell culture

Cited by 71 publications

References 48 publications

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Tunable zero-order drug delivery systems created by modified triaxial electrospinning

Conducting Polymers, Hydrogels and Their Composites: Preparation, Properties and Bioapplications

Contact Info

Product

Resources

About