Electrically controlled release of anticancer drug 5-fluorouracil from carboxymethyl cellulose hydrogels

Sangsuriyonk, Kittipon; Paradee, Nophawan; Sirivat, Anuvat

doi:10.1016/j.ijbiomac.2020.09.228

Cited by 26 publications

(8 citation statements)

References 61 publications

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“…Although cellulose does not easily dissolve in water, WS DOM possibly contained cellulose fragments and starch owing to the high cellulose content (38.72%) and soluble starch (0.071%) in WS (SI Table S5). For NPs-SM DOM , 1654 cm –1 represented the protein absorption peak and 1009 cm –1 represented the COC stretching vibration of the undigested cellulose in organic fertilizers. In general, changes were not observed in the absorption peaks of each functional group of the NPs.…”

Section: Resultsmentioning

confidence: 99%

Effect of Agricultural Organic Inputs on Nanoplastics Transport in Saturated Goethite-Coated Porous Media: Particle Size Selectivity and Role of Dissolved Organic Matter

Qiu

Zhao

et al. 2022

Environ. Sci. Technol.

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The transport of nanoplastics (NPs) through porous media is influenced by dissolved organic matter (DOM) released from agricultural organic inputs. Here, cotransport of NPs with three types of DOM (biochar DOM (BC DOM ), wheat straw DOM (WS DOM ), and swine manure DOM (SM DOM )) was investigated in saturated goethite (GT)coated sand columns. The results showed that codeposition of 50 nm NPs (50NPs) with DOM occurred due to the formation of a GT− DOM−50NPs complex, while DOM loaded on GT-coated sand and 400 nm NPs (400NPs) aided 400NPs transport due to electrostatic repulsion. According to the quantum chemical calculation, humic acid and cellulose played a significant role in 50NPs retardation. Owing to its high concentration, moderate humification index (HIX), and cellulose content, SM DOM exhibited the highest retardation of 50NPs transport and promoting effect on 400NPs transport. Owing to a high HIX, the effect of BC DOM on the mobility of 400NPs was higher than that of WS DOM . However, high cellulose content in WS DOM caused it to exhibit a 50NPs retardation ability that was similar to that of BC DOM . Our results highlight the particle size selectivity and significant influence of DOM type on the transport of NPs and elucidate their quantum and colloidal chemical-interface mechanisms in a typical agricultural environment.

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Section: Resultsmentioning

confidence: 99%

Effect of Agricultural Organic Inputs on Nanoplastics Transport in Saturated Goethite-Coated Porous Media: Particle Size Selectivity and Role of Dissolved Organic Matter

Qiu

Zhao

et al. 2022

Environ. Sci. Technol.

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“…Drug release behavior from ERHs under electrical stimulus can be controlled by three competing forces—polymer–polymer affinity, ionic pressure, and rubber elasticity—collectively calledmosmotic pressure. Disruption of the balance of these forces leads to swelling and de-swelling in ERHs [ 71 , 72 ]. The osmotic pressure of a hydrogel is equal to the surrounding aqueous environment at an equilibrium state.…”

Section: Electrically and Magnetically Responsive Hydrogels (E And Mrhs)mentioning

confidence: 99%

Smart Hydrogels for Advanced Drug Delivery Systems

Bordbar‐Khiabani

Gasik

2022

IJMS

138

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Since the last few decades, the development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from their environments, has become a thriving research frontier in the biomedical engineering field. Nowadays, drug delivery systems have received great attention and smart hydrogels can be potentially used in these systems due to their high stability, physicochemical properties, and biocompatibility. Smart hydrogels can change their hydrophilicity, swelling ability, physical properties, and molecules permeability, influenced by external stimuli such as pH, temperature, electrical and magnetic fields, light, and the biomolecules’ concentration, thus resulting in the controlled release of the loaded drugs. Herein, this review encompasses the latest investigations in the field of stimuli-responsive drug-loaded hydrogels and our contribution to this matter.

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“…127 In addition, the drug release rate through the hydrogel/nanogels can also be regulated by applying an electric field for non-ionic drugs, such as 5-fluorouracil, an anti-cancer drug. 128…”

Section: Drug Delivery Systemsmentioning

confidence: 99%