Electrical Stimulation Therapy and Wound Healing: Where Are We Now?

Isseroff, Roslyn Rivkah; Dahle, Sara E.

doi:10.1089/wound.2011.0351

Cited by 66 publications

(71 citation statements)

References 15 publications

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“…Our numerical model demonstrates that by non-contact application of an EF, we can induce a sufficient EF in the cell membrane and cytoplasm to manipulate protein expression and activate intracellular pathways as supported by our experimental results [3]. Such numerical modelling of EF -cell interactions is an essential and necessary part of the clinical translation process; it helps to establish therapeutic concepts and to advance approaches toward the development of non-pharmacological EF therapies [106][107][108], which can be applied locally and without direct contact with tissue [101,105,[109][110][111][112]. Importantly, our theoretical approach can be generalized to investigate the interaction of EF with cells of an arbitrary shape.…”

Section: Resultssupporting

confidence: 53%

“…Although on average these therapies show a beneficial effect on wound healing, the outcomes still vary significantly, which is likely due to wide variability in the wound type, patient type, medical personnel training, electrode placement, duration of stimulation and EF parameters used for stimulation. As a result, EF-based stimulation is not currently used as a standard therapy [102,105].…”

Section: Resultsmentioning

confidence: 99%

“…Important advantages of our approach for potential EF-based wound healing therapy is in a non-contact application of EF that does not require placement of electrodes on the skin, which may improve patient comfort and treatment compliance [102,105], and may eliminate the concerns related to application of direct current EF due to pH changes in the stimulated area [98]. Our numerical model demonstrates that by non-contact application of an EF, we can induce a sufficient EF in the cell membrane and cytoplasm to manipulate protein expression and activate intracellular pathways as supported by our experimental results [3].…”

Section: Resultsmentioning

confidence: 99%

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Modulation of cell function by electric field: a high-resolution analysis

Taghian

Narmoneva

Kogan

2015

J. R. Soc. Interface.

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Regulation of cell function by a non-thermal, physiological-level electromagnetic field has potential for vascular tissue healing therapies and advancing hybrid bioelectronic technology. We have recently demonstrated that a physiological electric field (EF) applied wirelessly can regulate intracellular signalling and cell function in a frequency-dependent manner. However, the mechanism for such regulation is not well understood. Here, we present a systematic numerical study of a cell-field interaction following cell exposure to the external EF. We use a realistic experimental environment that also recapitulates the absence of a direct electric contact between the field-sourcing electrodes and the cells or the culture medium. We identify characteristic regimes and present their classification with respect to frequency, location, and the electrical properties of the model components. The results show a striking difference in the frequency dependence of EF penetration and cell response between cells suspended in an electrolyte and cells attached to a substrate. The EF structure in the cell is strongly inhomogeneous and is sensitive to the physical properties of the cell and its environment. These findings provide insight into the mechanisms for frequency-dependent cell responses to EF that regulate cell function, which may have important implications for EF-based therapies and biotechnology development.

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Section: Resultssupporting

confidence: 53%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Modulation of cell function by electric field: a high-resolution analysis

Taghian

Narmoneva

Kogan

2015

J. R. Soc. Interface.

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“…With a slight change in instrumentation, the same device can also be used to measure voltage at each electrode with respect to a common reference, creating a map of the voltage and endogenous electric field across the wound. It is well known that cells can be directed to migrate with an applied electric field [32][33][34][35][36] , and there is evidence, although somewhat controversial, that applying an electric field may assist in the healing process 37 . The device demonstrated here provides the capability to test the extension of these theories from cells to complex tissues in vivo.…”

Section: Resultsmentioning

confidence: 99%

Impedance sensing device enables early detection of pressure ulcers in vivo

et al. 2015

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When pressure is applied to a localized area of the body for an extended time, the resulting loss of blood flow and subsequent reperfusion to the tissue causes cell death and a pressure ulcer develops. Preventing pressure ulcers is challenging because the combination of pressure and time that results in tissue damage varies widely between patients, and the underlying damage is often severe by the time a surface wound becomes visible. Currently, no method exists to detect early tissue damage and enable intervention. Here we demonstrate a flexible, electronic device that non-invasively maps pressure-induced tissue damage, even when such damage cannot be visually observed. Using impedance spectroscopy across flexible electrode arrays in vivo on a rat model, we find that impedance is robustly correlated with tissue health across multiple animals and wound types. Our results demonstrate the feasibility of an automated, non-invasive 'smart bandage' for early detection of pressure ulcers.

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“…The reported studies demonstrate great variability in the parameters of the ES application for the VEGF release, leading to an inability to generate sufficient evidence to support any one standard therapeutic approach. 25 …”

Section: Discussion Of Findings and Relevant Literaturementioning

confidence: 99%