Vascular Endothelial Growth Factor Release Following Electrical Stimulation in Human Subjects

Liebano, Richard Eloin; Machado, Aline Fernanda Perez

doi:10.1089/wound.2013.0427

Cited by 15 publications

(11 citation statements)

References 23 publications

(32 reference statements)

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“…Results of studies both in vitro and in vivo reveal that ES improves the healing process by promoting keratinocyte migration, improving wound perfusion, stimulating collagen synthesis (Kim, Cho and Lee, 2014), and inducing angiogenesis (Liebano and Machado, 2014). (Liebano and Machado, 2014).…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of the Effects of Vibration and Electrical Stimulation Therapies on the Acceleration of Wound Healing in Diabetic Ulcers

Sari¹,

Saryono²,

Sutrisna³

et al. 2017

J. Ners

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Introduction: Diabetic ulcers accompanied by ischemia is difficult to treat. Such ulcers require therapy that can improve the blood flow. Previous studies have revealed that two therapies could improve blood flow and accelerate the healing of diabetic ulcers; vibration and electrical stimulation (ES). However, it is unknown which of these two therapies is best at accelerating wound healing in diabetic ulcers. The purpose of this study was to compare both therapies in relation to accelerating the wound healing of diabetic ulcers. Methods: This study was an experimental study involving diabetic rats. The rats were divided into two groups: vibration and ES. Vibration and ES were applied for 10 minutes per day for 7 days. Wound size, inflammation, intensity of fibroblast infiltration, area of necrosis and degree of re-epithelialisation were compared. The difference in wound size was analysed using an independent t-test, while the histological data were analysed using a Mann-Whitney U-test. Results: On day 5 onwards, there was a thin slough in the ES group which was not present in the vibration group. Day 4 onwards and the wound size was significantly smaller in the vibration group than in the ES group. The intensity of inflammation was significantly less, and the degree of fibroblast infiltration was significantly higher in the vibration group compared with the ES group. Re-epithelialisation was more advanced in the vibration group than the ES group. Conclusions: Our study revealed that wound healing in diabetic ulcers following vibration was better than after ES. We suggest that nurses should use vibration rather than ES in clinical settings.

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Section: Introductionmentioning

confidence: 99%

A Comparative Study of the Effects of Vibration and Electrical Stimulation Therapies on the Acceleration of Wound Healing in Diabetic Ulcers

Sari¹,

Saryono²,

Sutrisna³

et al. 2017

J. Ners

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show abstract

“…Specific actions based on human in vitro, ex vivo and in vivo studies include: downregulation of inflammation, anti‐bacterial effects, increases in tissue oxygenation, wound blood flow, haemoglobin levels, angiogenesis, fibroblast proliferation and galvanotaxis. It also impacts the remodelling phase of wound healing via collagen effects (upregulation of mature collagen synthesis and increased collagen production) leading to accelerated wound contraction and greater wound tensile strength . Several different waveforms and delivery methods of ES have been utilized.…”

Section: Introductionmentioning

confidence: 99%

“…It also impacts the remodelling phase of wound healing via collagen effects (upregulation of mature collagen synthesis and increased collagen production) leading to accelerated wound contraction and greater wound tensile strength. [17][18][19][20][21][22][23][24][25][26] Several different waveforms and delivery methods of ES have been utilized. These include, but are not limited to, direct current (DC), alternating current (AC) and pulsed current (PC).…”

Section: Introductionmentioning

confidence: 99%

The efficacy of electrical stimulation in experimentally induced cutaneous wounds in animals

Ashrafi

Alonso-Rasgado

Baguneid

et al. 2016

Veterinary Dermatology

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Electrical stimulation has the potential to play a significant role in enhancing cutaneous wound healing in veterinary practice. Clinical studies are necessary to corroborate the findings from experimental studies which have shown promise including the use of alternating pulsed and direct current and the use of bio-electric dressings. The ideal ES device would need to be safe, easy to use, portable, noninvasive and aid wound healing by having a beneficial effect on all wound healing stages.

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“…Angiogenesis is an important event that is involved in the healing of various types of wounds and is primarily modulated by the release of vascular endothelial growth factor (VEGF) from endothelial cells, platelets, keratinocytes, and fibroblasts [ 59 ]. VEGF regulates the multiple biological functions of endothelial cells, thereby enhancing the production of vasodilatory mediators, increasing vascular permeability, and stimulating their migration, proliferation, and formation [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Effects and mechanisms of a microcurrent dressing on skin wound healing: a review

Peng

2014

Military Med Res

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The variety of wound types has resulted in a wide range of wound dressings, with new products frequently being introduced to target different aspects of the wound healing process. The ideal wound dressing should achieve rapid healing at a reasonable cost, with minimal inconvenience to the patient. Microcurrent dressing, a novel wound dressing with inherent electric activity, can generate low-level microcurrents at the device-wound contact surface in the presence of moisture and can provide an advanced wound healing solution for managing wounds. This article offers a review of the effects and mechanisms of the microcurrent dressing on the healing of skin wounds.

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Vascular Endothelial Growth Factor Release Following Electrical Stimulation in Human Subjects

Cited by 15 publications

References 23 publications

A Comparative Study of the Effects of Vibration and Electrical Stimulation Therapies on the Acceleration of Wound Healing in Diabetic Ulcers

A Comparative Study of the Effects of Vibration and Electrical Stimulation Therapies on the Acceleration of Wound Healing in Diabetic Ulcers

The efficacy of electrical stimulation in experimentally induced cutaneous wounds in animals

Effects and mechanisms of a microcurrent dressing on skin wound healing: a review

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