Electrical stimulation over the left inferior frontal gyrus (IFG) determines long-term effects in the recovery of speech apraxia in three chronic aphasics

Marangolo, Paola; Marinelli, Chiara Valeria; Bonifazi, Silvia; Fiori, Valentina; Ceravolo, Maria Gabriella; Provinciali, Leandro; Tomaiuolo, Francesco

doi:10.1016/j.bbr.2011.08.008

Cited by 126 publications

(133 citation statements)

References 35 publications

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“…Along this line, classic and modern human intracranial electrophysiology (Gastaut & Bert, 1954;Tremblay, et al, 2004) and surface electroencephalography (Cebolla, Palmero-Soler, Dan, & Cheron, 2014;Cochin, Barthelemy, Lejeune, Roux, & Martineau, 1998;Cochin, Barthelemy, Roux, & Martineau, 1999;Pfurtscheller, Neuper, Andrew, & Edlinger, 1997;Pineda, 2005) showed that observation and execution of simple movements lead to a comparable activation (mu-rhythm suppression; 8-12 Hz) in IFG. Furthermore, beyond its well known role in speech production, the (left) IFG has been found to be involved also in a wide range of language-related activities including sign language production (Willems, Ozyurek, & Hagoort, 2007), lexical selection and retrieval (Krieger-Redwood & Jefferies, 2014), and word complexity categorization (Wright, Randall, Marslen-Wilson, & Tyler, 2011), as well as in language-unrelated activities such as semantic knowledge (Zhu, et al, 2012), motor planning (Marangolo, et al, 2011), and response inhibition (van Rooij, et al, 2015). This body of evidence supports that IFG contributes to build multimodal representations of object semantics, conveyed in various modality-independent forms of communication.…”

Section: Introductionmentioning

confidence: 99%

Inferior frontal oscillations reveal visuo-motor matching for actions and speech: evidence from human intracranial recordings

Halje

Seeck²,

Blanke

et al. 2015

Neuropsychologia

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The neural correspondence between the systems responsible for the execution and recognition of actions has been suggested both in humans and non-human primates. Apart from being a key region of this visuo-motor observation-execution matching (OEM) system, the human inferior frontal gyrus (IFG) is also important for speech production. The functional overlap of visuo-motor OEM and speech, together with the phylogenetic history of the IFG as a motor area, has led to the idea that speech function has evolved from pre-existing motor systems and to the hypothesis that an OEM system may exist also for speech. However, visuo-motor OEM and speech OEM have never been compared directly. We used electrocorticography to analyze oscillations recorded from intracranial electrodes in human fronto-parieto-temporal cortex during visuo-motor (executing or visually observing an action) and speech OEM tasks (verbally describing an action using the first or third person pronoun). The results show that neural activity related to visuo-motor OEM is widespread in the frontal, parietal, and temporal regions. Speech OEM also elicited widespread responses partly overlapping with visuo-motor OEM sites (bilaterally), including frontal, parietal, and temporal regions. Interestingly a more focal region, the inferior frontal gyrus (bilaterally), showed both visuo-motor OEM and speech OEM properties independent of orolingual speech-unrelated movements. Building on the methodological advantages in human invasive electrocorticography, the present findings provide highly precise spatial and temporal information to support the existence of a modalityindependent action representation system in the human brain that is shared between systems for performing, interpreting and describing actions.

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Section: Introductionmentioning

confidence: 99%

Inferior frontal oscillations reveal visuo-motor matching for actions and speech: evidence from human intracranial recordings

Halje

Seeck²,

Blanke

et al. 2015

Neuropsychologia

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“…Moreover, tDCS may have helped to "prime" cortical excitability (i.e., improve functional connectivity and efficiency) in the functional pathways associated with Broca's area, including corticostriatal pathways [8,35,31] and connections between Broca's area and the SMA [10].…”

Section: Discussionmentioning

confidence: 99%

“…In a longer-term study, after training on a repetition task for five days, aphasic patients showed greater accuracy in the tDCS vs. sham condition [35]. These improvements transferred to other language abilities, including word repetition, reading, and written naming, and improvements lasted for two months after tDCS-suggesting the ability of tDCS to induce lasting benefits in clinical populations [35]. However, no studies to date have investigated the effects of tDCS to Broca's area on behaviors unrelated to language.…”

Section: Tdcsmentioning

confidence: 95%

“…Anodal tDCS to Broca's area has also been shown to enhance verbal fluency [33] and improve performance on a picturenaming task in healthy adults [34]. In a longer-term study, after training on a repetition task for five days, aphasic patients showed greater accuracy in the tDCS vs. sham condition [35]. These improvements transferred to other language abilities, including word repetition, reading, and written naming, and improvements lasted for two months after tDCS-suggesting the ability of tDCS to induce lasting benefits in clinical populations [35].…”

Section: Tdcsmentioning

confidence: 99%

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Transcranial direct current stimulation (tDCS) to broca’s area: persisting effects on non-verbal motor behaviors

Hupfeld¹,

Ketcham²,

Schneider³

2017

Neurol Disord Therap

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Transcranial direct current stimulation (tDCS) has been investigated as a novel therapy for addressing motor, cognitive, and language deficits. While anodal tDCS to the primary motor cortex results in improved motor behaviors, few studies have examined if tDCS to other areas involved in motor output produces similar benefits. Although Broca's area is associated with speech production and grammar acquisition, it also contributes to motor planning and output in non-speech tasks. This study involved applying anodal tDCS to Broca's area and observing effects on non-verbal motor output. Twenty young adults completed two testing sessions separated by one week. Participants received either 30 minutes of 1.0 mA of anodal tDCS to Broca's area or sham stimulation. During stimulation (or sham), participants completed two tasks: (1) a limits of stability dynamic balance task and (2) a simple (SRT)/choice reaction time(CRT) tasks. Subjects who received tDCS to first performed significantly better on SRT and dynamic balance accuracy and showed a trend for dynamic balance speed when tested one week later compared to those who received sham stimulation first. These findings indicate that Broca's area is involved in the production of non-verbal motor behaviors and may have implications novel combined speech and movement therapy interventions.

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“…The usefulness of tDCS in chronic stroke was summarized by Stagg [32]. There are controversy results in the long term usefulness of speech therapy in fluent aphasia, but the non-invasive stimulation over the language area can improve [33][34][35][36] and tDCS [37,38]. There is a reversion of the imbalance of interhemispheric inhibition, speech induced activity shifts to the left side instead of both sides or right side and formation of a new language network which may responsible for the better outcome of aphasia several weeks after stimulation.…”

Section: Influence On Different Symptoms Of Stroke With Noninvasive Bmentioning

confidence: 99%

Non-Invasive Brain Stimulation and its Supposed Site of Action in the Rehabilitation of Parkinson’s Disease and Stroke

2014

Int J Neurorehabilitation Eng

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Two non-invasive brain stimulations have spread all over the world: repetitive trasncranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). TMS is based on the current induction with a changing electromagnetic field in the nervous system [1] while tDCS changes the polarity of cell membranes [2]. General Aspects of TMS and tDCSTMS is widely used in research and daily medical practice. It was introduced as a diagnostic tool about thirty years ago to test functioning of motor pathways [3]. The motor evoked potential (MEP) and the measurement of the central motor conduction time (CMCT) has entered into daily practice. The other parameters of the electrophysiological examination assessed by TMS are mainly used in scientific work [4]. TMS aids the diagnosis of multiple sclerosis, furthermore the prognosis of stroke can be indicated by TMS [5]. Different paired pulse stimulations with TMS give a new insight into the function of the brain. In recent years, sophisticated brain plasticity can be detected by the measurement of intracortical excitability [6,7]. We learnt from these studies how different conditions can modify brain plasticity. It can be changed by different diseases, altered by drugs [8] and strongly influenced by non-invasive stimulations [2,9]. The single TMS and one session of repetitive stimulation have a short after-effect. However the effect of repeated stimulation for days exceeds the stimulation period and many times it lasts for months. This effect of rTMS has made it useful for therapy for the last 20 years. The low and high frequency stimulation, continuous theta burst stimulation (cTBS), intermittent theta burst stimulation (iTBS), anodal or cathodal stimulation are used for therapy. The intensity of rTMS was around the motor threshold and the duration of stimulation was 7-10 days. This paper reviews the most frequently studied symptoms of Parkinson's diseases and stroke although rTMS has been tried to treat all disorders of the central nervous system (CNS). Parkinson's Disease (PD)The first protocol was low frequency, low intensity monophasic stimulation for 7 days which improved the Parkinsonian symptoms and its results were maintained for several months after the stimulation [10,11]. The authors performed a "dose (intensity) response" curve with 1 Hz stimulation and they indicated that there is an optimal intensity using 1 Hz [12]. We learned from these studies that the therapeutic effect of rTMS develops after a delay in time of a few weeks. The improvement can be maintained for several months. The later studies confirmed these observations not only in PD but other diseases. Although, the high frequency stimulations over the primary motor cortex [13,14] had the same effect on the Parkinsonian scores but the after-effect lasted for a shorter time. iTBS over the dorsolateral prefrontal area improved the depression without effecting on bradykinesia [15]. The studies concentrated on varying the frequency which was applied but they did not try to find the optimal in...

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Electrical stimulation over the left inferior frontal gyrus (IFG) determines long-term effects in the recovery of speech apraxia in three chronic aphasics

Cited by 126 publications

References 35 publications

Inferior frontal oscillations reveal visuo-motor matching for actions and speech: evidence from human intracranial recordings

Inferior frontal oscillations reveal visuo-motor matching for actions and speech: evidence from human intracranial recordings

Transcranial direct current stimulation (tDCS) to broca’s area: persisting effects on non-verbal motor behaviors

Non-Invasive Brain Stimulation and its Supposed Site of Action in the Rehabilitation of Parkinson’s Disease and Stroke

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