Electrical stimulation of the vagus nerve improves intestinal blood flow after trauma and hemorrhagic shock

Yagi, Masayuki; Ueno, Atsushi; Nakamura, Hajime; Akabori, Hiroya; Senda, Atsushi; Kojima, Mitsuaki; Aiboshi, Junichi; Costantini, Todd W.; Coimbra, Raúl; Otomo, Yasuhiro

doi:10.1016/j.surg.2019.09.024

Cited by 15 publications

(14 citation statements)

References 38 publications

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“…It is tempting to speculate that this hemodynamic alteration was caused by an instant vagal stimulation by AT. As recently described by Yagi et al vagal disbalance is proposed to be the driver for abdominal perfusion disturbances 19 . Electrical stimulation of the vagal nerve after trauma–hemorrhagic shock resulted in improved intestinal blood flow and normalization of the decreased heart rate and the impaired MAP 19 .…”

Section: Discussionmentioning

confidence: 94%

“…19 Electrical stimulation of the vagal nerve after trauma-hemorrhagic shock resulted in improved intestinal blood flow and normalization of the decreased heart rate and the impaired MAP. 19 The temporary declining body temperature immediately after AT (data not shown), despite the use of the rectal feed-back loop heating-plate system to maintain the core temperature of the mice at 37°C, also indicates vagal stimulation. In rats, an increased loss of body heat induced by 2-mercaptoacetate (MA) could be abrogated by vagotomy.…”

Section: Discussionmentioning

confidence: 99%

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Temporal–spatial organ response after blast‐induced experimental blunt abdominal trauma

et al. 2021

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Abdominal trauma (AT) is of major global importance, particularly with the increased potential for civil, terroristic, and military trauma. The injury pattern and systemic consequences of blunt abdominal injuries are highly variable and frequently underestimated or even missed, and the pathomechanisms remain still poorly understood. Therefore, we investigated the temporal-spatial organ and immune response after a standardized blast-induced blunt AT. Anesthetized mice were exposed to a single blast wave centered on the epigastrium. At 2, 6, or 24 h after trauma, abdominal organ damage was assessed macroscopically, microscopically, and biochemically. A higher degree of trauma severity, determined by a reduction of the distance between the epigastrium and blast inductor, was reflected by a reduced survival rate. The hemodynamic monitoring during the first 120 min after AT revealed a decline in the mean arterial pressure within the first 80 min, whereas the heart rate remained quite stable. AT induced a systemic damage and inflammatory response, evidenced by elevated HMGB-1 and IL-6 plasma levels. The macroscopic injury pattern of the abdominal organs (while complex) was consistent, with the following frequency: liver > pancreas > spleen > left kidney > intestine > right kidney > others > lungs and was reflected by microscopic liver and pancreas damages. Plasma levels of organ dysfunction markers increased during the first 6 h after AT and subsequently declined, indicating an early, temporal impairment of the function on a multi-organ level. The established highly reproducible murine blunt AT, with time-and trauma-severity-dependent organ injury patterns, systemic inflammatory response, and impairment of various organ functions, reflects characteristics of human AT. In the future, thisThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Temporal–spatial organ response after blast‐induced experimental blunt abdominal trauma

et al. 2021

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“…Here, the technology proposed in this paper allow us to record from the rat PHR nerve with a higher averaged SNR (

dB). Helical, cuffs or flat electrodes, with mono-, bi-, or tri-polar characteristics have been mainly tested for neurostimulation [ 57 , 58 , 59 ]. Further investigations are needed to compare the performances of those electrodes with multicontact OE in ENG recording.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection

Avdeew

Bergé-Laval

Rolle

et al. 2021

Sensors

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Effective closed-loop neuromodulation relies on the acquisition of appropriate physiological control variables and the delivery of an appropriate stimulation signal. In particular, electroneurogram (ENG) data acquired from a set of electrodes applied at the surface of the nerve may be used as a potential control variable in this field. Improved electrode technologies and data processing methods are clearly needed in this context. In this work, we evaluated a new electrode technology based on multichannel organic electrodes (OE) and applied a signal processing chain in order to detect respiratory-related bursts from the phrenic nerve. Phrenic ENG (pENG) were acquired from nine Long Evans rats in situ preparations. For each preparation, a 16-channel OE was applied around the phrenic nerve’s surface and a suction electrode was applied to the cut end of the same nerve. The former electrode provided input multivariate pENG signals while the latter electrode provided the gold standard for data analysis. Correlations between OE signals and that from the gold standard were estimated. Signal to noise ratio (SNR) and ROC curves were built to quantify phrenic bursts detection performance. Correlation score showed the ability of the OE to record high-quality pENG. Our methods allowed good phrenic bursts detection. However, we failed to demonstrate a spatial selectivity from the multiple pENG recorded with our OE matrix. Altogether, our results suggest that highly flexible and biocompatible multi-channel electrode may represent an interesting alternative to metallic cuff electrodes to perform nerve bursts detection and/or closed-loop neuromodulation.

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“…However, a signi cant decrease in MAP despite a small decrease in HR in the vagotomized group of Vag+LHS may be partly linked to the reduction in vascular resistance. It has been reported that cervical vagus nerve stimulation (VNS) after trauma and hemorrhagic shock modulates release of norepinephrine and thereby reduce MAP and HR and increase intestinal blood ow, whereas abdominal vagotomy has an opposite effect (Yagi et al, 2020). In addition, sub-diaphragmatic vagotomy increases the release of epinephrine under stressful conditions (Mravec et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Subdiaphragmatic Vagotomy on Heart Rate Variability and Lung Inflammation in Rats with Severe Hemorrhagic Shock

Khodadadi

Ketabchi

Khodabandeh

et al. 2021

Preprint

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Background The role of the sub-diaphragmatic branch of the vagus nerve in mediating heart rate variability (HRV) and inflammatory reaction to long term hemorrhagic shock has not been determined prior to this study. Methods Male Sprague-Dawley rats were divided into four groups of Sham, sub-diaphragmatic vagotomized (Vag), long term (130±2 minutes) hemorrhagic shock (LHS), and sub-diaphragmatic vagotomized with LHS (Vag+LHS). Hemodynamic parameters were recorded and HRV calculated during multiple phases of hemorrhagic shock. The expressions of TNF-α and iNOS were measured in the spleen and lung tissues at the conclusion of the protocol. Results Decreases in blood pressure during blood withdrawal were identical in the LHS and Vag+LHS groups. However, heart rate only decreased in the Nadir-1 phase of the LHS group. HRV indicated increased power in the very-low, low, and high (VLF, LF, and HF) frequency bands during the Nadir-1 phase of the LHS group and decreased power in the Vag+LHS group. There was metabolic acidosis partially compensated with respiratory system in the LHS and Vag+LHS groups. Increases of TNF-α and iNOS expression in the spleen and lung of the LHS group were reversed in the Vag+LHS group. Conclusion This study indicates that sub-diapragmatic vagotomy increases lung inflammatory reactions and blunts the cardiac vagal tone surge in response to severe hemorrhagic shock.

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Electrical stimulation of the vagus nerve improves intestinal blood flow after trauma and hemorrhagic shock

Cited by 15 publications

References 38 publications

Temporal–spatial organ response after blast‐induced experimental blunt abdominal trauma

Temporal–spatial organ response after blast‐induced experimental blunt abdominal trauma

Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection

The Effect of Subdiaphragmatic Vagotomy on Heart Rate Variability and Lung Inflammation in Rats with Severe Hemorrhagic Shock

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