Electrical stimulation enhances early palatal wound healing in mice

Ferreira, Camila Lopes; Jardini, Maria Aparecida Neves; Nunes, Camilla Magnoni Moretto; Bernardo, Daniella Vicensotto; Casarin, Renato Corrêa Viana; Gedraite, Estevão dos Santos; Mathias, Márcio Antônio; Liu, Fei; Mendonça, Gustavo; Mendonça, Daniela Baccelli Silveira; Santamaría, Mauro Pedrine

doi:10.1016/j.archoralbio.2020.105028

Cited by 9 publications

(5 citation statements)

References 50 publications

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“…In dentistry, it has been investigated in periodontitis ( Kaynak et al, 2005 ; Tomofuji et al, 2013 ), orthodontic tooth movement ( Qamruddin et al, 2017 ; Mistry et al, 2020 ) and bony defects ( Kaynak et al, 2005 ). One study on the ES effect on the palate wound healing reported that it could accelerate the process of palate wound healing, especially in the early stages ( Ferreira et al, 2021 ). The results showed that the level of IL-6, IL-10, TNF-α and VEGF was lower than the sham ES group ( Ferreira et al, 2021 ).…”

Section: Aspects Of Studiesmentioning

confidence: 99%

“…One study on the ES effect on the palate wound healing reported that it could accelerate the process of palate wound healing, especially in the early stages ( Ferreira et al, 2021 ). The results showed that the level of IL-6, IL-10, TNF-α and VEGF was lower than the sham ES group ( Ferreira et al, 2021 ). However, the mechanisms by which cells respond to ES were not figured out.…”

Section: Aspects Of Studiesmentioning

confidence: 99%

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Current insights in the preclinical study of palatal wound healing and oronasal fistula after cleft palate repair

Chen,

Yang,

Yin

et al. 2023

Front. Cell Dev. Biol.

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Poor palatal wound healing after cleft palate repair could lead to unfavorable prognosis such as oronasal fistula (ONF), which might affect the patient’s velopharyngeal function as well as their quality of life. Thus, restoring poor palatal wound healing for avoiding the occurrence of ONF should be considered the key to postoperative care after cleft palate repair. This review provided current insights in the preclinical study of poor palatal wound healing after cleft palate repair. This review comprehensively introduced the animal model establishment for palatal wound healing and related ONF, including the models by mice, rats, piglets, and dogs, and then demonstrated the aspects for investigating poor palatal wound healing and related treatments, including possible signaling pathways that could be involved in the formation of poor palatal wound healing, the related microbiota changes because of the deformity of palatal structure, and the studies for potential therapeutic strategies for palatal wound healing and ONF. The purpose of this review was to show the state of the art in preclinical studies about palatal wound healing after cleft palate repair and to show the promising aspects for better management of palatal wound healing.

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Section: Aspects Of Studiesmentioning

confidence: 99%

Section: Aspects Of Studiesmentioning

confidence: 99%

Current insights in the preclinical study of palatal wound healing and oronasal fistula after cleft palate repair

Chen,

Yang,

Yin

et al. 2023

Front. Cell Dev. Biol.

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“…Skin or mucosal wounds resemble a natural endogenous battery that generates an electric current, and electrical stimulation can mimic this current at the wound and initiate or accelerate wound repair. One study using electrical stimulation in mucosal wounds of the hard palate in mice found that electrical stimulation accelerated the effect of early wound closure and positively affected the inflammatory markers IL-6, interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and VEGF [ 102 ]. A recent clinical randomized controlled trial also showed that using a low-intensity electrotherapy protocol can accelerate wound healing in the palate and reduce patient discomfort after FGG surgery [ 97 ].…”

Section: Future Directionsmentioning

confidence: 99%

Biomaterials derived from hard palate mucosa for tissue engineering and regenerative medicine

Ren

Jiang

Zhang

et al. 2023

Materials Today Bio

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“…Current research seeks to determine whether these therapeutic modalities can also be useful for problematic intraoral wound healing. For instance, rodent studies suggest that electrical stimulation may also be useful for supporting intraoral (e.g., palatal, gingival) wound healing [ 94 , 97 ]. Photobiomodulation therapy has also been shown to improve healing in patients following palatal graft harvest [ 98 ].…”

Section: Mucosal Repair In the Oral Cavitymentioning

confidence: 99%

Endogenous Mechanisms of Craniomaxillofacial Repair: Toward Novel Regenerative Therapies

desJardins-Park

Mascharak

Longaker

et al. 2021

Front. Oral. Health

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In the fields of oral and craniomaxillofacial surgery, regeneration of multiple tissue types—including bone, skin, teeth, and mucosal soft tissue—is often a desired outcome. However, limited endogenous capacity for regeneration, as well as predisposition of many tissues to fibrotic healing, may prevent recovery of normal form and function for patients. Recent basic science research has advanced our understanding of molecular and cellular pathways of repair in the oral/craniofacial region and how these are influenced by local microenvironment and embryonic origin. Here, we review the current state of knowledge in oral and craniomaxillofacial tissue repair/regeneration in four key areas: bone (in the context of calvarial defects and mandibular regeneration during distraction osteogenesis); skin (in the context of cleft lip/palate surgery); oral mucosa (in the context of minimally scarring repair of mucosal injuries); and teeth (in the context of dental disease/decay). These represent four distinct healing processes and outcomes. We will discuss both divergent and conserved pathways of repair in these contexts, with an eye toward fundamental mechanisms of regeneration vs. fibrosis as well as translational research directions. Ultimately, this knowledge can be leveraged to develop new cell-based and molecular treatment strategies to encourage bone and soft tissue regeneration in oral and craniomaxillofacial surgery.

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Electrical stimulation enhances early palatal wound healing in mice

Cited by 9 publications

References 50 publications

Current insights in the preclinical study of palatal wound healing and oronasal fistula after cleft palate repair

Current insights in the preclinical study of palatal wound healing and oronasal fistula after cleft palate repair

Biomaterials derived from hard palate mucosa for tissue engineering and regenerative medicine

Endogenous Mechanisms of Craniomaxillofacial Repair: Toward Novel Regenerative Therapies

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