Electrical stimulation combined with exercise increase axonal regeneration after peripheral nerve injury

Asensio-Pinilla, E.; Udina, Esther; Jaramillo, Jessica; Navarro, Xavier

doi:10.1016/j.expneurol.2009.05.034

Cited by 194 publications

(193 citation statements)

References 50 publications

Supporting

Mentioning

164

Contrasting

Unclassified

Order By: Relevance

“…With regard to LT, our results show that it did not have a beneficial effect on soleus and TA muscle performance after NT. Therefore, our findings suggest that the possible increased nerve regeneration induced by LT or electrostimulation observed by histological analysis 4,8,9 has no major impact on muscle weakness and functional innervation. Discrepancies between nerve histology, motor function, and electrophysiology measures have been reported to occur during muscle reinnervation.…”

Section: Lt Had No Effect When Fully Functional Innervationmentioning

confidence: 60%

“…Increased neuromuscular activity via physical exercise, such as locomotor training (LT) and electrostimulation, have been shown to improve nerve regeneration and muscle reinnervation, as assessed using histological measures [4][5][6][7][8][9] and analysis of coordinated and complex motor functions, namely toe-spreading reflex and locomotion. 6,10 Together these earlier studies suggested that increased neuromuscular activity may improve the full recovery of muscle performance after nerve injury, such as maximal force production.…”

Section: Muscle Nerve 45: 567-577 2012mentioning

confidence: 99%

“…Our first hypothesis was that LT would improve muscle performance after nerve injuries that allow muscle reinnervation (nerve transection alone or crush), because muscle inactivity reduces contractility 15,16 and increased neuromuscular activity improves or accelerates nerve regeneration and muscle reinnervation. [4][5][6][7][8][9][10] Second, we examined whether LT would improve the performance of the permanently denervated soleus muscle (nerve transection with excision), as it was recently demonstrated that mechanical signals coming from passive stretch could reduce atrophy of denervated muscle 17 and thus, possibly, the deficit in maximal force production. Moreover, we studied the effect of LT on soleus muscle contractility of mice that exhibit permanent disturbed neuromuscular junction functioning due to AChE deficiency at the neuromuscular junction.…”

Section: Muscle Nerve 45: 567-577 2012mentioning

confidence: 99%

See 2 more Smart Citations

Effect of locomotor training on muscle performance in the context of nerve–muscle communication dysfunction

et al. 2012

View full text Add to dashboard Cite

Introduction: The effects of locomotor training (LT) on skeletal muscle after peripheral nerve injury and acetylcholinesterase deficiency are not well documented. Methods: We determined the effects of LT on mouse soleus muscle performance after sciatic nerve transection with excision (full and permanent denervation), nerve transection (partial functional reinnervation), nerve crush (full denervation with full functional reinnervation), and acetylcholinesterase deficiency (alteration in neuromuscular junction functioning). Results: We found no significant effect of LT on the recovery of soleus muscle weight, maximal force in response to muscle stimulation, and fatigue resistance after nerve transection with or without excision. However, LT significantly increased soleus muscle fatigue resistance after nerve crush and acetylcholinesterase deficiency. Moreover, hindlimb immobilization significantly aggravated the deficit in soleus muscle maximal force production and atrophy after nerve crush. Conclusions: LT is beneficial, and reduced muscle use is detrimental for intrinsic muscle performance in the context of disturbed nerve-muscle communication.

show abstract

Section: Lt Had No Effect When Fully Functional Innervationmentioning

confidence: 60%

Section: Muscle Nerve 45: 567-577 2012mentioning

confidence: 99%

Section: Muscle Nerve 45: 567-577 2012mentioning

confidence: 99%

See 1 more Smart Citation

Effect of locomotor training on muscle performance in the context of nerve–muscle communication dysfunction

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Despite being somewhat controversial, some authors have suggested exercise as a complementary therapeutic resource 33 and, when combined with other therapeutic practices such as electrotherapy 34 or phototherapy 6,19 , can result in a better recovery prognosis for peripheral nerve injuries. The ELSG group in this research, which combined laser therapy with swimming, presented a better functional result when compared to the ELG and ESG group, respectively.…”

Section: Discussionmentioning

confidence: 99%

Efeito da associação da laserterapia com a natação no reparo morfológico do nervo isquiático e na recuperação funcional de ratos submetidos à axonotmese

et al. 2016

View full text Add to dashboard Cite

show abstract

“…111 Asensio-Pinilla et al 112 used brief electrical stimulation applied soon after sciatic nerve injury in rats, or moderate intensity treadmill training or a combination of both. Each led to accelerated nerve regeneration and enhanced muscle reinnervation.…”

Section: Exercise and Bonementioning

confidence: 99%

Spinal cord injury and physical activity: preservation of the body

Galea

2011

Spinal Cord

View full text Add to dashboard Cite

Setting: Spinal cord injury (SCI) causes devastating loss of function and can result in serious secondary complications. Although significant advances are being made to develop cellular and molecular therapies to promote regeneration, it is important to optimize physical interventions. Objectives: The objective of this review was to examine the evidence for the effects of physical rehabilitation strategies on health and fitness, and maintenance of target systems below the level of injury (for example, muscle, bone, circulation).Results: Exercise appears to be a potent means of achieving these goals, using a variety of strategies. Conclusion: Physical rehabilitation after SCI needs to move beyond the goal of maximizing independence to focus on maintenance of optimum health and fitness as well as maintenance of target system function below the level of injury. Issues requiring further investigation include identification of the optimum dosage of interventions to achieve specific goals, for example, prevention of muscle atrophy and osteoporosis, and development and validation of simple clinical measures to monitor the changes in body composition. Adoption of a classification system for physical interventions and standardized outcome measures would facilitate large-scale observational studies to identify the critical variables contributing to better outcomes.

show abstract

Electrical stimulation combined with exercise increase axonal regeneration after peripheral nerve injury

Cited by 194 publications

References 50 publications

Effect of locomotor training on muscle performance in the context of nerve–muscle communication dysfunction

Effect of locomotor training on muscle performance in the context of nerve–muscle communication dysfunction

Efeito da associação da laserterapia com a natação no reparo morfológico do nervo isquiático e na recuperação funcional de ratos submetidos à axonotmese

Spinal cord injury and physical activity: preservation of the body

Contact Info

Product

Resources

About