Electrical Potential Distribution within the Inner Ear: A preliminary study for vestibular prosthesis design

Marianelli, Prisca; Luciani, L. Bassi; Micera, Silvestro

doi:10.1109/embc.2012.6346599

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…It can be hypothesized that an improved ability to image the micro-anatomy of the inner ear would increase the performance of such an implant, by contributing to improvements in electrode design and processing strategies. The same arguments hold true for the newly developed vestibular implant (VI) (Marianelli et al, 2012 ).…”

Section: Introductionmentioning

confidence: 68%

“…The placement of these electrodes in, for example, vestibular implants can be simulated in detailed 3D models of varying anatomy. This may help to achieve maximal selectivity and sensitivity of electrical stimulation (Marianelli et al, 2012 ). Lastly, the combination of a total overview of the inner ear (Figures 3 , 4 ) combined with selective visualizations (Figures 5 – 9 ) might also prove useful in education.…”

Section: Discussionmentioning

confidence: 99%

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Optimization of 3D-Visualization of Micro-Anatomical Structures of the Human Inner Ear in Osmium Tetroxide Contrast Enhanced Micro-CT Scans

et al. 2018

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Introduction: Knowledge of the neuro-anatomical architecture of the inner ear contributes to the improvement and development of cochlear and vestibular implants. The present knowledge is mainly based on two-dimensional images (histology) or derived models that simplify the complexity of this architecture. This study investigated the feasibility of visualizing relevant neuro-anatomical structures of the inner ear in a dynamic three-dimensional reproduction, using a combination of staining, micro-CT imaging and an image processing algorithm.Methods: Four fresh cadaveric temporal bones were postfixed with osmium tetroxide (OsO4) and decalcified with EDTA. Micro-CT was used for scanning at 10 μm (4 scans) and 5.5 μm (1 scan) voxel resolution. A new image processing algorithm was developed and the scans were visualized in open source software.Results: OsO4 enhanced the contrast in all scans and the visualization was substantially improved by the image processing algorithm. The three-dimensional renderings provided detailed visualization of the whole inner ear. Details were visible up to the size of individual neurons, nerve crossings and the specific neuro-anatomical structures such as the tunnel of Corti.Conclusion: The combination of OsO4, micro-CT and the proposed image processing algorithm provides an accurate and detailed visualization of the three-dimensional micro-anatomy of the human inner ear.

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Section: Introductionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Optimization of 3D-Visualization of Micro-Anatomical Structures of the Human Inner Ear in Osmium Tetroxide Contrast Enhanced Micro-CT Scans

et al. 2018

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“…young children/neonates) are available. As the PEA technology has only recently been commercialized, it was important to validate the platform against an existing benchmark technology (e.g., Bio-Plex multiplex immunoassay) which has FDA approval [ 37 ]. The expression profiles of 13 common oncoproteins were compared between both platforms.…”

Section: Discussionmentioning

confidence: 99%

A novel multiplexed immunoassay identifies CEA, IL-8 and prolactin as prospective markers for Dukes’ stages A-D colorectal cancers

et al. 2015

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BackgroundCurrent methods widely deployed for colorectal cancers (CRC) screening lack the necessary sensitivity and specificity required for population-based early disease detection. Cancer-specific protein biomarkers are thought to be produced either by the tumor itself or other tissues in response to the presence of cancers or associated conditions. Equally, known examples of cancer protein biomarkers (e.g., PSA, CA125, CA19-9, CEA, AFP) are frequently found in plasma at very low concentration (pg/mL-ng/mL). New sensitive and specific assays are therefore urgently required to detect the disease at an early stage when prognosis is good following surgical resection. This study was designed to meet the longstanding unmet clinical need for earlier CRC detection by measuring plasma candidate biomarkers of cancer onset and progression in a clinical stage-specific manner. EDTA plasma samples (1 μL) obtained from 75 patients with Dukes’ staged CRC or unaffected controls (age and sex matched with stringent inclusion/exclusion criteria) were assayed for expression of 92 human proteins employing the Proseek® Multiplex Oncology I proximity extension assay. An identical set of plasma samples were analyzed utilizing the Bio-Plex Pro™ human cytokine 27-plex immunoassay.ResultsSimilar quantitative expression patterns for 13 plasma antigens common to both platforms endorsed the potential efficacy of Proseek as an immune-based multiplex assay for proteomic biomarker research. Proseek found that expression of Carcinoembryonic Antigen (CEA), IL-8 and prolactin are significantly correlated with CRC stage.ConclusionsCEA, IL-8 and prolactin expression were found to identify between control (unaffected), non-malignant (Dukes’ A + B) and malignant (Dukes’ C + D) stages.Electronic supplementary materialThe online version of this article (doi:10.1186/s12014-015-9081-x) contains supplementary material, which is available to authorized users.

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A Computational Framework for Electrical Stimulation of Vestibular Nerve

Marianelli

Capogrosso

Luciani

et al. 2015

IEEE Trans. Neural Syst. Rehabil. Eng.

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The vestibular organs are very important to generate reflexes critical for stabilizing gaze and body posture. Vestibular diseases significantly reduce the quality of life of people who are affected by them. Some research groups have recently started developing vestibular neuroprostheses to mitigate these symptoms. However, many scientific and technological issues need to be addressed to optimise their use in clinical trials. We developed a computational model able to mimic the response of human vestibular nerves and which can be exploited for "in-silico" testing of new strategies to design implantable vestibular prostheses. First, a digital model of the vestibular system was reconstructed from anatomical data. Monopolar stimulation was delivered at different positions and distances from ampullary nerves. The electrical potential induced by the injected current was computed through finite-element methods and drove extra-cellular stimulation of fibers in the vestibular, facial, and cochlear nerves. The electrical activity of vestibular nerves and the resulting eye movements elicited by different stimulation protocols were investigated. A set of electrode configurations was analyzed in terms of selectivity at increasing injected current. Electrode position along the nerve plays a major role in producing undesired activity in other nontargeted nerves, whereas distance from the fiber does not significantly affect selectivity. Indications are provided to minimize misalignment in nonoptimal electrode locations. Eye movements elicited by the different stimulation protocols are calculated and compared to experimental values, for the purpose of model validation.

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Electrical Potential Distribution within the Inner Ear: A preliminary study for vestibular prosthesis design

Cited by 3 publications

References 13 publications

Optimization of 3D-Visualization of Micro-Anatomical Structures of the Human Inner Ear in Osmium Tetroxide Contrast Enhanced Micro-CT Scans

Optimization of 3D-Visualization of Micro-Anatomical Structures of the Human Inner Ear in Osmium Tetroxide Contrast Enhanced Micro-CT Scans

A novel multiplexed immunoassay identifies CEA, IL-8 and prolactin as prospective markers for Dukes’ stages A-D colorectal cancers

A Computational Framework for Electrical Stimulation of Vestibular Nerve

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