Electrical nanogap devices for biosensing

Chen, Xing; Guo, Zheng; Yang, Gui-Mei; Li, Jie; Li, Minqiang; Liu, Jinhuai; Huang, Xing-Jiu

doi:10.1016/s1369-7021(10)70201-7

Cited by 195 publications

(69 citation statements)

References 77 publications

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“…They provide a powerful test-bed for mesoscopic physics [3][4][5][6][7] . Electronic nanogaps with gapwidths in the sub-5 nm range are particularly interesting as they are suitable for embedding and probing molecules to investigate electron transport mechanisms and strong light-matter interactions on a molecular-level.…”

Section: Introductionmentioning

confidence: 99%

“…Accurately producing sub-5 nm wide gaps requires a patterning resolution of a few atomic layers, which is a great technological challenge even if only a few devices are to be realized 12 . Existing nanogap fabrication techniques include mask-defined etching processes 13 , layer-defined sacrificial etching processes 14 , material-growth processes 1,15 , self-assembly processes 7,16 , and the break junction (BJ) technique [17][18][19] . Each of these approaches suffers from severe drawbacks, including limited process control, limited dimensional accuracy, limited process scalability and risk of residual contaminants inside the nanogaps.…”

Section: Introductionmentioning

confidence: 99%

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Design and fabrication of crack-junctions

2017

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Nanogap electrodes consist of pairs of electrically conducting tips that exhibit nanoscale gaps. They are building blocks for a variety of applications in quantum electronics, nanophotonics, plasmonics, nanopore sequencing, molecular electronics, and molecular sensing. Crack-junctions (CJs) constitute a new class of nanogap electrodes that are formed by controlled fracture of suspended bridge structures fabricated in an electrically conducting thin film under residual tensile stress. Key advantages of the CJ methodology over alternative technologies are that CJs can be fabricated with wafer-scale processes, and that the width of each individual nanogap can be precisely controlled in a range from o 2 to 4100 nm. While the realization of CJs has been demonstrated in initial experiments, the impact of the different design parameters on the resulting CJs has not yet been studied. Here we investigate the influence of design parameters such as the dimensions and shape of the notches, the length of the electrode-bridge and the design of the anchors, on the formation and propagation of cracks and on the resulting features of the CJs. We verify that the design criteria yields accurate prediction of crack formation in electrode-bridges featuring a beam width of 280 nm and beam lengths ranging from 1 to 1.8 μm. We further present design as well as experimental guidelines for the fabrication of CJs and propose an approach to initiate crack formation after release etching of the suspended electrode-bridge, thereby enabling the realization of CJs with pristine electrode surfaces.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design and fabrication of crack-junctions

2017

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“…As the results, at the present time detecting the diseases before it occurs is possible therefore doctors could be able to control not making the diseasing worst. In past many techniques, had been identified in order to apply it but today it had been in realities [1][2][3][4][5]. The components used in order to produce sensors are nanogap, nanoparticles, nano thin film etc.…”

Section: Introductionmentioning

confidence: 99%

“…In a typical capacitor, the space between the two plates non-transferable but transducing it, In the normal capacitor, the distance between the two plates non-movable, but transducing it variable this capability of varying the dielectric with allow to measure noticeable changes [1][2][3]. The operational mechanism is as follows.…”

Section: Introductionmentioning

confidence: 99%

In-House fabrication and Electrical characterization of planner si-nanogap

Dhahi

Adam

Hashim

2017

J. Phys.: Conf. Ser.

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“…Summing up, electrospinning technology provides the following opportunities in the development of advanced nanobiosensors: (i) to generate membranes designed with excellent (or tuned on purpose) interconnected porosity, predictable pore geometries and sizes, large global pore volumes; (ii) to obtain nanofibres with desired diameters, then extending specific surface area; (iii) to regulate, in a single electrospinning deposition step, the desired thickness of the applied membrane, from tens of nanometres to several micro-meters; (iv) to use a large variety of materials (organic and inorganic polymers, composites, polymer-blends, hybrids, ceramics, metallic nanoparticles) exhibiting a great deal of different interacting properties [11]. All these features make electrospinning as an outstanding technology in the fabrication of nanobiosensors suitable for the detection of a multitude of analytes.…”

Section: Introductionmentioning

confidence: 99%

Electrospinning-Based Nanobiosensors

Cesare

Macagnano

2015

Electrospinning for High Performance Sensors

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Biological interactions in biosensors occur through different mechanisms, on the basis of the type of biological receptor elements employed therein that confer the biological specificity to the biosensors themselves (biocatalytic, biocomplexing or bioaffinity biosensors). The use of different transduction systems (amperometric, potentiometric, field-effect transistors, piezometric and conductometric) defines the mode of detection. The interest and relevance of nanomaterials in the fabrication of nanobiosensors lie in their extraordinary properties that make them ideally suited and very promising for sensing applications. The resulting nanobiosensors are capable of sensing analytes in traces with fast, precise and accurate biological identification through miniaturised and easy to use systems. These advanced sensors are also characterised by lower detection limits, higher sensitivity values and high stability, and can further offer multi-detection possibilities. These exceptional features make nanobiosensors as the favourite tools in quality control, food safety, and traceability for their capacity of revealing and warning people against the presence of pathogens, toxins and pollutants, as well as bioterrorism agents. Despite the outstanding properties of these nanobiosensors, however, the efficiency of the biorecognition agent and the number of biorecognition sites available for interacting with target analytes can limit the sensitivity of this kind of sensors. The number of available biorecognition sites is directly related to the surface area of the sensor. Electrospinning technology can significantly increase the sensitivity of biosensors by replacing the typical planar interactive surface of conventional biosensors with a mat of electrospun nonwoven nanofibres, thereby taking advantage of the ultrahigh surface area offered by electrospun nanofibres. Moreover, adjusting the electrospinning process to produce

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Electrical nanogap devices for biosensing

Cited by 195 publications

References 77 publications

Design and fabrication of crack-junctions

Design and fabrication of crack-junctions

In-House fabrication and Electrical characterization of planner si-nanogap

Electrospinning-Based Nanobiosensors

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