Electrical Impedance Spectroscopy of Benign and Malignant Prostatic Tissues

Abstract

The electrical properties of benign and malignant prostate tissues differ significantly. This should be considered for use as a diagnostic tool. The differences observed between cancer and benign prostatic hyperplasia are especially important since current screening methods do not reliably differentiate between the 2 conditions.

Electrical Impedance Spectroscopy to Aid Parathyroid Identification and Preservation in Central Compartment Neck Surgery

“…15 In human prostate tissue, electrical impedance spectroscopy (EIS) demonstrated different EI patterns in normal and malignant tissues; this has potential to improve the accuracy of prostate cancer diagnosis. 16,17 Kerner et al 18 assessed EIS patterns of breast lesions using visual and numerical methods and compared them against the American College of Radiology (ACR) ranking system in 51 mammograms. EIS images and numerical scores were able to identify 83% and 67% respectively of lesions considered suspicious on mammography (ACR [4][5].…”

Comparative study of separation betweenex vivoprostatic malignant and benign tissue using electrical impedance spectroscopy and electrical impedance tomography

“…Thus the EIT reconstructions can be more easily compared to other studies, e.g. (Halter et al 2008b, 2009). As an example, we compare the discrete conductivity at 10 kHz and 100 kHz described here to results from (Halter et al 2009) in figure 8.…”

“…It has the potential to be a low-cost, radiation free, real-time technique, which could significantly impact clinical outcomes thereby leading to enhanced quality of life for patients following RP. Based on previous findings, EIS has been successfully shown to distinguish between malignant and benign prostate tissue (Halter et al 2008a, 2007, 2008b). Cancerous prostatic tissue has a significantly lower conductivity than benign stroma and glandular prostatic tissues at frequencies ranging from 0.1 to 100 kHz and a permittivity that is significantly higher than all benign tissues at 100 kHz (Halter et al 2009).…”

Development of High Frequency Microfluidic Biosensors for Intracellular Analysis

“…Especially, the study of cell dielectric properties based on bio-impedance measurements has been recognized for a long time as very promising label-free and potentially non-invasive solutions [1]. Previous works have already reported on the interest of electrical impedance spectroscopy analysis to discriminate significantly benign and malignant prostatic tissue suggesting that the assessment of electrical properties of cancer tissue might provide to clinicians new biomarkers to aid in diagnosis [2]. But this original alternative to distinguish benign and malignant cancers was restricted to the full tissue scale.…”