Electrical impedance model for evaluation of skin irritation in rabbits and humans

Abstract

The proposed electrical model of skin seems to be suitable for the detection and interpretation of changes in the impedance characteristics of skin induced by SLS in rabbits and humans.

Capsaicin Used on Skin Influences Ion Transport Pathways: An in vitro Study

“…As the sodium flux changes in response to TRPV1 receptor stimulation, both immediate and prolonged effects of capsaicin should be reflected in electrophysiological parameters. We used rabbit skin as model, as its relative electro-osmotic and electrorepulsive contributions are similar to those of human skin [39,40,41]. The comparison of electrophysiological parameters of skin fragments with inhibited and uninhibited sodium ion transport enabled us to particularize the mechanism of immediate and prolonged dermal response to capsaicin exposure.…”

Modeling of bioimpedance for human skin based on fractional distributed-order modified cole model

“…In terms of single frequency electrical circuits in BIS, the Cole equation determines behavior of the biological tissue [9], [24] especially for some points of the human skin [25]. The parameters of impedance were obtained from an electrical impedance system based on current response to a voltage step excitation.…”

“…As it is a well-known, three expressions for the impedance allow one to describe a wide range of experimental data: Cole-Cole function, Cole-Davidson function and Havriliak-Negami function [1], [2], [8], [9].…”

“…Based on this fact, some authors [10] have replaced the ideal capacitor in the Debey model by the CPE in modeling the layers of the stratum corneum. Cole impedance model was used to analyze human and rabbit irritated skin [9]. Not only the Cole distribution, but also any log normal distribution of relaxation times will produce curves which are indistinguishable from depressed circular arcs [14].…”

Desenvolvimento de formulações cosméticas hidratantes e avaliação da eficácia por métodos biofísicos

“…Além da resistência, a impedância da pele está relacionada, também, com a capacitância e com as múltiplas freqüências que podem ser aplicadas na pele. A medida da impedância reflete as alterações estruturais e químicas dos tecidos vivos, e é altamente dependente da quantidade de lipídeos no estrato córneo (HILDERBRANT, ZIEGLER, WOLLINA, 1998;FLUHR et al, 1999;NICANDER, OLLMAR, 2004;FERREIRA, SILVA, SOUZA, 2007).…”