Electric Stimulus-Responsive Chitosan/MNP Composite Microbeads for a Drug Delivery System

Mohapatra, Ankita; Wells, Carlos M.; Jennings, Amber; Ghimire, Madhav; Mishra, Sanjay R.; Morshed, Bashir I.

doi:10.1109/tbme.2019.2911579

Cited by 13 publications

(9 citation statements)

References 33 publications

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“…[ 129 ] In addition, the integration of AgNPs into drug carriers or scaffolds could allow for controlled drug release and effective localized therapy after receiving appropriate ES. [ 130 ] That being said, it is worth noting that the release of silver ions is potentially biotoxic; thus, more attention needs to be paid to the concentration and distribution of AgNPs in vivo.…”

Section: Conductive Biomaterials Designed For Bone and Articular Cart...mentioning

confidence: 99%

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Chen,

Yang,

Cai

et al. 2024

Adv Funct Materials

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The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries is lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized to play an important role in bone and cartilage homeostasis and regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes and holds promise as an external intervention to enhance the synthesis of the extracellular matrix, thereby accelerating the process of bone and cartilage regeneration. Hence, electroactive biomaterials have been considered a biomimetic approach to ensure functional recovery by integrating various physiological signals, including electrical, biochemical, and mechanical signals. This review will discuss the role of endogenous bioelectricity in bone and cartilage tissue, as well as the effects of ES on cellular behaviors. Then, recent advances in electroactive materials and their applications in bone and cartilage tissue regeneration are systematically overviewed, with a focus on their advantages and disadvantages as tissue repair materials and performances in the modulation of cell fate. Finally, the significance of mimicking the electrophysiological microenvironment of target tissue is emphasized and future development challenges of electroactive biomaterials for bone and cartilage repair strategies are proposed.

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Section: Conductive Biomaterials Designed For Bone and Articular Cart...mentioning

confidence: 99%

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Chen,

Yang,

Cai

et al. 2024

Adv Funct Materials

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“…[ 37 ] More recently, electro-responsive chitosan/magnetic nanoparticles Composite Microbeads were developed and loaded with vancomycin drug. [ 38 ] Furthermore, poly (2-ethylaniline) dextran-based hydrogel was formulated as a transdermal drug delivery system for electrically controlled diclofenac drug release. The application of an electrical stimulus results in drug release by Fickian diffusion combined with matrix swelling.…”

Section: Externally Regulated Pulsatile Release Systemsmentioning

confidence: 99%

Recent advances in remotely controlled pulsatile drug delivery systems

Khalifa

Zyad

Mohammed

et al. 2022

J Adv Pharm Technol Res

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Pharmaceutical technology is drastically developing to enhance the efficacy and safety of drug therapy. Pulsatile delivery systems, in turn, gained attraction for their ability to deliver the right drug amount to the right body site, at the right time which is advantageous over conventional dosage forms. Their use is associated with increased patient compliance and allows on-demand drug delivery as well as customizable therapy. Recent technologies have been implemented to further develop pulsatile delivery systems for more precise determination of the dosage timing and duration as well as the location of drug release. Great interests are directed towards externally regulated pulsatile release systems which will be the focus of this review. The recent advances will be highlighted in remotely controlled delivery systems. This includes electro responsive, light-responsive, ultrasound responsive, and magnetically induced pulsatile systems as well as wirelessly controlled implantable systems. The current status of these technologies will be discussed as well as the recent investigations and future applications.

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“…These significant findings showed that T-cell regulation was increased by CD8 + T-cell infiltration and its ratio to eliminate primary and secondary tumours. Furthermore, Mohapatra et al (2020) used polyethylene glycol dimethacrylate (PEGDMA) as an electrical biosensor and an IONP as a magnetic targetor to release vancomycin (Vcm) in an IONP/Chi/PEGDMA drug carrier [ 56 ]. The electrical triggers were generated by 100 Hz bipolar electric pulses, the ion distributions and migrations of which were studied by COMSOL stimulation software.…”

Section: Electrical Biosensors For Electrical Trigger In Drug Deliver...mentioning

confidence: 99%

CuZn Complex Used in Electrical Biosensors for Drug Delivery Systems

Miskon

Zaidi

2022

Materials

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This paper is to discuss the potential of using CuZn in an electrical biosensor drug carrier for drug delivery systems. CuZn is the main semiconductor ingredient that has great promise as an electrochemical detector to trigger releases of active pharmaceutical ingredients (API). This CuZn biosensor is produced with a green metal of frameworks, which is an anion node in conductive polymers linked by bioactive ligands using metal–polymerisation technology. The studies of Cu, Zn, and their oxides are highlighted by their electrochemical performance as electrical biosensors to electrically trigger API. The three main problems, which are glucose oxidisation, binding affinity, and toxicity, are highlighted, and their solutions are given. Moreover, their biocompatibilities, therapeutic efficacies, and drug delivery efficiencies are discussed with details given. Our three previous investigations of CuZn found results similar to those of other authors’ in terms of multiphases, polymerisation, and structure. This affirms that our research is on the right track, especially that related to green synthesis using plant extract, CuZn as a nanochip electric biosensor, and bioactive ligands to bind API, which are limited to the innermost circle of the non-enzymatic glucose sensor category.

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Electric Stimulus-Responsive Chitosan/MNP Composite Microbeads for a Drug Delivery System

Cited by 13 publications

References 33 publications

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Recent advances in remotely controlled pulsatile drug delivery systems

CuZn Complex Used in Electrical Biosensors for Drug Delivery Systems

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