Electric Field-Assisted In Situ Precise Deposition of Electrospun γ-Fe2O3/Polyurethane Nanofibers for Magnetic Hyperthermia

Abstract

A facial electrospinning method of in situ precise fabricating magnetic fibrous membrane composed of polyurethane (PU) nanofibers decorated with superparamagnetic γ-Fe2O3 nanoparticles with simultaneous heat generation in response to alternating magnetic field (AMF) is reported. In this method, a conical aluminum auxiliary electrode is used to regulate the electrostatic field and affect the process of electrospinning for the in situ rapid and precise deposition of electrospun γ-Fe2O3/PU fibers. The auxiliary conical electrode can extend the jet stabilization zone of the precursor solution four times longer than that of without auxiliary electrode, which can achieve the precise control of the fiber deposition area. Moreover, the electrospun composite fibrous membranes show a rapid temperature increase from room temperature to 43 °C in 70 s under the AMF, which exhibits faster heating rate and higher heating temperature compared to the samples fabricated without the assist of the auxiliary electrode. The present results demonstrate that the in situ precise electrospinning with the help of an auxiliary conical electrode has the potential as a manipulative method for preparing magnetic composite fibers as well as magnetic hyperthermia of cancer therapy.

Magnetic-Electrospinning Synthesis of γ-Fe2O3 Nanoparticle–Embedded Flexible Nanofibrous Films for Electromagnetic Shielding

“…The magnetization, M, versus the applied magnetic field, H (from −15 kOe to 15 kOe), and the enlarged image (from −0.3 to 0.3 kOe) are shown in Figure 4d. The hysteresis loop demonstrates the superparamagnetic behavior of the composite nanofibers [47,61,62]. The magnetization increases sharply when the applied field is increased; M is nearly saturated at about 2 kOe, and M s is around 25 emu/g for PVP/γ-Fe 2 O 3 nanofibers fabricated by MES with 3 wt % γ-Fe 2 O 3 , 18 emu/g for 2 wt %, and 10 emu/g for 1 wt %.…”

Functional Electrospun Fibers for Local Therapy of Cancer

“…Combining AMF with controlled drug release is a promising route to achieving an on-demand drug release system, with the chance to improve cancer treatment efficacy. Song et al synthesized polyurethane nanofibers with iron oxide nanoparticles for thermal cancer therapy, where the temperature reached 43 °C under AMF for 70 s [84]. Similarly, TiO 2 / cobalt ferrite/chitosan nanofibers were fabricated for cancer chemotherapy and magnetic therapy, where TiO 2 nanoparticles were mixed with cobalt ferrite to control the temperature rise, which contributed to its application in localized cancer therapy [85].…”

Elastomagnetic nanofiber wires by magnetic field assisted electrospinning

“…The possibility of producing different types of nanofiber wires, able of a magnetically induced giant relative deformation, is very promising in view of their functionalization in those conditions where the filiform structure can lead to advantages. In fact, on the basis of recent bibliography, MENWs development seems to open renewals and finalizations for biomedical applications [43][44][45][46], sensing devices [47][48][49][50], electromagnetic components [51,52], absorbers [53,54], tissue engineering [7,55,56] and, in particular, to biocompatible components sensitive to external stimuli in order to regenerate or to activate the contraction and dilatation of tendons and muscles that have lost their functionality [57][58][59][60][61].…”