Electric Factors in Wound Healing

Farber, Paulo Luiz; Isoldi, Felipe Contoli; Ferreira, Lydia Masako

doi:10.1089/wound.2019.1114

Cited by 22 publications

(19 citation statements)

References 131 publications

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“…This transcutaneous voltage across a wound has been termed skin battery and must be preserved for normal skin wound healing. 78 Studies have investigated the effects of electrical stimulation on fibroblasts during wound healing and found that fibroblast migration is voltage dependent and direct electric current increases deoxyribonucleic acid (DNA) and collagen synthesis in fibroblasts by 20 and 100%, respectively, in pig skin. 79,80 The endogenous electrodynamic field also plays a vital role in keratinocyte, macrophage, and monocyte migration in addition to other immune system functions.…”

Section: Electrical Stimulation and Wound Healingmentioning

confidence: 99%

“…In addition, electric current can be directly applied to acupuncture needles in a procedure called electroacupuncture. 78 Acupuncture has been reported to improve wound healing in animal and burn patient human studies by decreasing wound size, decreasing inflammation, promoting epidermal regeneration, and improving microcirculation.…”

Section: Electrical Stimulation and Wound Healingmentioning

confidence: 99%

“…79,80 The endogenous electrodynamic field also plays a vital role in keratinocyte, macrophage, and monocyte migration in addition to other immune system functions. 78 Electrical stimulation has also been found to increase blood flow and VEGF production in stimulated cultured skeletal muscle. 81 For chronic wounds, several types of exogenous electrical stimulation modalities such as pulsed electromagnetic field therapy, monophasic high-voltage electric stimulation, and low level laser therapy have been described to improve and accelerate wound healing.…”

Section: Electrical Stimulation and Wound Healingmentioning

confidence: 99%

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Current and Future Developments in Wound Healing

Davis

Hom

2023

Facial Plast Surg

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Poor wound healing on the face and neck can lead to significant morbidity and dissatisfaction in facial plastic surgery. With current advances in wound healing management and commercially available biologic and tissue-engineered products, there are several options available to optimize acute wound healing and treat delayed or chronic wounds. This article summarizes some of the key principals and recent developments in wound healing research in addition to potential future advancements in the field of soft tissue wound healing.

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Section: Electrical Stimulation and Wound Healingmentioning

confidence: 99%

Section: Electrical Stimulation and Wound Healingmentioning

confidence: 99%

Section: Electrical Stimulation and Wound Healingmentioning

confidence: 99%

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Current and Future Developments in Wound Healing

Davis

Hom

2023

Facial Plast Surg

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“…One of the most important applications of Li is in energy storage as Li-ion batteries, which are the most promising electrochemical energy storage devices [ 161 ]. Electrotherapy creates new opportunities in wound healing [ 162 ], and wearable ionic triboelectric nanogenerator (iTENG) patches (created from a stretchable platform based on LiCl-loaded organogels and elastomeric microtubular structures) utilized the therapeutic effects of Li-ions in wound healing, and moreover contributed to creating and transmitting electrical stimulation ( Figure 4 ) [ 163 ], which is very promising in wound healing applications [ 164 ].…”

Section: Lithium and Its Biological Effectsmentioning

confidence: 99%

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

Farmani

Salmeh

Golkar

et al. 2022

JFB

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Lithium (Li) is a metal with critical therapeutic properties ranging from the treatment of bipolar depression to antibacterial, anticancer, antiviral and pro-regenerative effects. This element can be incorporated into the structure of various biomaterials through the inclusion of Li chloride/carbonate into polymeric matrices or being doped in bioceramics. The biocompatibility and multifunctionality of Li-doped bioceramics present many opportunities for biomedical researchers and clinicians. Li-doped bioceramics (capable of immunomodulation) have been used extensively for bone and tooth regeneration, and they have great potential for cartilage/nerve regeneration, osteochondral repair, and wound healing. The synergistic effect of Li in combination with other anticancer drugs as well as the anticancer properties of Li underline the rationale that bioceramics doped with Li may be impactful in cancer treatments. The role of Li in autophagy may explain its impact in regenerative, antiviral, and anticancer research. The combination of Li-doped bioceramics with polymers can provide new biomaterials with suitable flexibility, especially as bio-ink used in 3D printing for clinical applications of tissue engineering. Such Li-doped biomaterials have significant clinical potential in the foreseeable future.

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“…Bioelectricity is a basic attribute of living organisms and is necessary for regulating the vascular network during embryonic development, tissue repair, and tumor progression [ [10] , [11] , [12] ]. Thus, regulating the bioelectric balance of blood vessels might be an alternative strategy for normalizing tumor vasculature.…”

Section: Introductionmentioning

confidence: 99%