Elderberry (Sambucus nigra L.) extracts promote anti-inflammatory and cellular antioxidant activity

Ferreira, Sandrine S.; Martins-Gomes, Carlos; Nunes, Fernando M.; Silva, Amélia M.

doi:10.1016/j.fochx.2022.100437

Cited by 30 publications

(29 citation statements)

References 40 publications

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“…This experiment provided evidence of the protective role of elderberry extract against the toxicity exerted by t -BOOH oxidative stress. The overall results of this research demonstrate the ability of elderberry extract to inhibit and suppress oxidative stress and inflammation [ 119 ].…”

Section: Health Effects Of European Elderberry and American Elderberrymentioning

confidence: 96%

Elderberry Extracts: Characterization of the Polyphenolic Chemical Composition, Quality Consistency, Safety, Adulteration, and Attenuation of Oxidative Stress- and Inflammation-Induced Health Disorders

et al. 2023

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Elderberry is highly reputed for its health-improving effects. Multiple pieces of evidence indicate that the consumption of berries is linked to enhancing human health and preventing or delaying the onset of chronic medical conditions. Compared with other fruit, elderberry is a very rich source of anthocyanins (approximately 80% of the polyphenol content). These polyphenols are the principals that essentially contribute to the high antioxidant and anti-inflammatory capacities and the health benefits of elderberry fruit extract. These health effects include attenuation of cardiovascular, neurodegenerative, and inflammatory disorders, as well as anti-diabetic, anticancer, antiviral, and immuno-stimulatory effects. Sales of elderberry supplements skyrocketed to $320 million over the year 2020, according to an American Botanical Council (ABC) report, which is attributable to the purported immune-enhancing effects of elderberry. In the current review, the chemical composition of the polyphenolic content of the European elderberry (Sambucus nigra) and the American elderberry (Sambucus canadensis), as well as the analytical techniques employed to analyze, characterize, and ascertain the chemical consistency will be addressed. Further, the factors that influence the consistency of the polyphenolic chemical composition, and hence, the consistency of the health benefits of elderberry extracts will be presented. Additionally, adulteration and safety as factors contributing to consistency will be covered. The role of elderberry in enhancing human health alone with the pharmacological basis, the cellular pathways, and the molecular mechanisms underlying the observed health benefits of elderberry fruit extracts will be also reviewed.

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Section: Health Effects Of European Elderberry and American Elderberrymentioning

confidence: 96%

Elderberry Extracts: Characterization of the Polyphenolic Chemical Composition, Quality Consistency, Safety, Adulteration, and Attenuation of Oxidative Stress- and Inflammation-Induced Health Disorders

et al. 2023

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“…Other classes of antimicrobials are now available to treat staph infections. However, all of them have adverse effects, and to achieve lasting success, the use of additional therapies is also required [3] [20] demonstrated "antiinflammatory activity of black elderberry, establishing a dose-dependent inhibition of nitric oxide release by lipopolysaccharide-stimulated RAW 264.7 cells pre-exposed to elderberry extracts. The authors also reported antioxidant protection of cells after exposure to elderberry extract (50 µg/mL) by preventing up to 90% of tert-butyl hydroperoxide (t-BOOH)-induced toxicity.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, elderberry extracts prevent cellular glutathione depletion, inhibit the production of reactive oxygen species (ROS), abnormal morphological changes and DNA fragmentation, in response to t-BOOH oxidative damage". A dose-dependent anti-inflammatory activity of elderberry fruit extracts has been observed [20]. It is due to the synergistic effect between the phenolic and polar compounds contained in it, such as sugars, etc.…”

Section: Introductionmentioning

confidence: 99%

“…These extracts have strong anti-inflammatory and antioxidant potential, which may be due to the phytochemical profile (eg, anthocyanin, phenolic acid) of elderberry. These two bioactivities are crucial to reduce or prevent some disorders related to inflammatory status and ROS production [20]. In experiments with rats, H. perforatum has been shown to have antiinflammatory properties and significantly reduce all inflammatory parameters.…”

Section: Introductionmentioning

confidence: 99%

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Determination of the Anti-inflammatory and Anti-microbial Activity of a Cosmetic Product Silver Stop® Cream

Dimitrov¹,

Popova

Gotova³

et al. 2023

J. Pharm. Res. Int.

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The anti-inflammatory and antimicrobial effects of a cream containing extracts of African geranium (Pelargonium sidoides DC.), black elderberry (Sambucus nigra L.) and St. John's wort (Hypericum perforatum L.) in colloidal nanosilver (AgNPs) at a concentration of 30 ppm, denoted as SILVER STOP® cream (SS® cream) was examined In vitro. The research was performed with Staphylococcus aureus (ATCC-6538 and two clinical strains). Suspension tests for determination the time of antimicrobial action of SS® cream were used. SS® cream showed significant antimicrobial activity. In suspension with a density of 104 cells.mL-1S. aureus died after 60 minutes of exposure to SS® cream. In suspension with concentration of 106 cells.mL-1, after 2 h only single cells remained viable. The anti-inflammatory effect was evaluated using human epithelial cell line HT-29, incubated with a type strain of S. aureus. After treatment with SS® cream, results have shown a statistically significant reduction of the levels of the pro-inflammatory cytokinesIL-6, IL-8, IP-10 and IL-1β.

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“…Elderberry contains polyphenols such as anthocyanins, flavonols, and phenolic acids [6]. Due to the abundant polyphenols present in elderberry, several studies have been reported on the bioactivities of elderberry, such as antioxidant, antibacterial, anti-inflammatory, and immune-stimulating activity [7,8]. In particular, elderberry contains a large number of anthocyanins, including cyanidin derivatives such as cyanidin-3-glucoside, cyanidin-3sambubioside, and cyanidin 3-sambubioside-5-glucoside [9].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Major Extraction Variables to Improve Recovery of Anthocyanins from Elderberry by Response Surface Methodology

et al. 2022

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Elderberry, which is well known for its richness in anthocyanin, is attracting attention in the bioindustry as a functional material with high antioxidant capacity. The aim of this study is to optimize extraction conditions to more effectively recover anthocyanins from elderberry. In a fundamental experiment to determine the suitable solvent, various GRAS reagents, such as acetone, ethanol, ethyl acetate, hexane, and isopropyl alcohol, were used, and total phenol and anthocyanin contents were detected as 9.0 mg/g-biomass and 5.1 mg/g-biomass, respectively, only in the extraction using ethanol. Therefore, ethanol was selected as the extraction solvent, and an experimental design was performed to derive a response surface model with temperature, time, and EtOH concentration as the main variables. The optimal conditions for maximal anthocyanin recovery were determined to be 20.0 °C, 15.0 min, and 40.9% ethanol, and the total anthocyanin content was 21.0 mg/g-biomass. In addition, the total phenol and flavonoid contents were detected as 67.4 mg/g-biomass and 43.8 mg/g-biomass, respectively. The very simple and economical extraction conditions suggested in this study contributed to improving the utilization potential of anthocyanin, a useful antioxidant derived from elderberry.

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Elderberry (Sambucus nigra L.) extracts promote anti-inflammatory and cellular antioxidant activity

Cited by 30 publications

References 40 publications

Elderberry Extracts: Characterization of the Polyphenolic Chemical Composition, Quality Consistency, Safety, Adulteration, and Attenuation of Oxidative Stress- and Inflammation-Induced Health Disorders

Elderberry Extracts: Characterization of the Polyphenolic Chemical Composition, Quality Consistency, Safety, Adulteration, and Attenuation of Oxidative Stress- and Inflammation-Induced Health Disorders

Determination of the Anti-inflammatory and Anti-microbial Activity of a Cosmetic Product Silver Stop® Cream

Optimization of Major Extraction Variables to Improve Recovery of Anthocyanins from Elderberry by Response Surface Methodology

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