Elastomeric biocomposite of silver-containing mesoporous bioactive glass and poly(1,8-octanediol citrate): Physiochemistry and in vitro antibacterial capacity in tissue engineering applications

Pourshahrestani, Sara; Zeimaran, Ehsan; Kadri, Nahrizul Adib; Gargiulo, Nicola; Jindal, Hassan Mahmood; Hasikin‬, Khairunnisa; Naveen, Sangeetha Vasudevaraj; Sekaran, Shamala Devi; Kamarul, Tunku

doi:10.1016/j.msec.2019.01.022

Cited by 16 publications

(19 citation statements)

References 66 publications

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“…Synthesis of Poly(1,8‐Octanediol Citrate) Prepolymer : POC was synthesized as per previously published methods . Briefly, POC prepolymer was synthesized by melting citric acid (CA) and 1,8‐octanediol (OD), with monomer ratio of CA:OD (1:1.1), in a 500 mL three‐necked round bottom flask under constant nitrogen flow at 160–165 °C, followed by stirring at 140–145 °C for 1 h. The POC prepolymer was refrigerated until required.…”

Section: Methodsmentioning

confidence: 99%

Self‐Healing Polyester Urethane Supramolecular Elastomers Reinforced with Cellulose Nanocrystals for Biomedical Applications

Zeimaran

Pourshahrestani

Kadri

et al. 2019

Macromolecular Bioscience

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Stretchable self-healing urethane-based biomaterials have always been crucial for biomedical applications; however, the strength is the main constraint of utilization of these healable materials. Here, a series of novel, healable, elastomeric, supramolecular polyester urethane nanocomposites of poly(1,8octanediol citrate) and hexamethylene diisocyanate reinforced with cellulose nanocrystals (CNCs) are introduced. Nanocomposites with various amounts of CNCs from 10 to 50 wt% are prepared using solvent casting technique followed by the evaluation of their microstructural features, mechanical properties, healability, and biocompatibility. The synthesized nanocomposites indicate significantly higher tensile modulus (approximately 36-500-fold) in comparison to the supramolecular polymer alone. Upon exposure to heat, the materials can reheal, but nevertheless when the amount of CNC is greater than 10 wt%, the self-healing ability of nanocomposites is deteriorated. These materials are capable of rebonding ruptured parts and fully restoring their mechanical properties. In vitro cytotoxicity test of the nanocomposites using human dermal fibroblasts confirms their good cytocompatibility. The optimized structure, self-healing attributes, and noncytotoxicity make these nanocomposites highly promising for tissue engineering and other biomedical applications.

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Section: Methodsmentioning

confidence: 99%

Self‐Healing Polyester Urethane Supramolecular Elastomers Reinforced with Cellulose Nanocrystals for Biomedical Applications

Zeimaran

Pourshahrestani

Kadri

et al. 2019

Macromolecular Bioscience

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“…This can be done, for instance, by incorporating inorganic components such as hydroxyapatite 177–181 and bioactive glass. 182–185 In addition, the incorporation of organic materials, such as DNA, polypeptides such as resilin, antibodies, proteins, and lysosomes, has been carried out to manufacture materials that respond to the application of a stimulus. 186…”

Section: Advanced Applications Of Bioelastomersmentioning

confidence: 99%

Bioelastomers: current state of development

Alonso¹,

Enríquez-Medrano²,

Kumar

et al. 2022

J. Mater. Chem. A

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“…For example, multidrug-resistant (MDR) phenotypes of S. aureus and P. aeruginosa have been identified, causing infectious wounds [ 153 , 154 ]. In this regard, the use of metallic antibacterial elements (e.g., Ag) is suggested as an appropriate alternative for inhibiting MDR bacteria [ 155 , 156 , 157 , 158 , 159 ]. As one of the most well-known antibacterial agents, Ag has been using for inhibiting and killing a broad range of bacterial species [ 160 ].…”

Section: Mbgs For Skin Cancer Therapymentioning

confidence: 99%

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

et al. 2021

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Exploring new therapies for managing skin wounds is under progress and, in this regard, mesoporous silica nanoparticles (MSNs) and mesoporous bioactive glasses (MBGs) offer great opportunities in treating acute, chronic, and malignant wounds. In general, therapeutic effectiveness of both MSNs and MBGs in different formulations (fine powder, fibers, composites etc.) has been proved over all the four stages of normal wound healing including hemostasis, inflammation, proliferation, and remodeling. The main merits of these porous substances can be summarized as their excellent biocompatibility and the ability of loading and delivering a wide range of both hydrophobic and hydrophilic bioactive molecules and chemicals. In addition, doping with inorganic elements (e.g., Cu, Ga, and Ta) into MSNs and MBGs structure is a feasible and practical approach to prepare customized materials for improved skin regeneration. Nowadays, MSNs and MBGs could be utilized in the concept of targeted therapy of skin malignancies (e.g., melanoma) by grafting of specific ligands. Since potential effects of various parameters including the chemical composition, particle size/morphology, textural properties, and surface chemistry should be comprehensively determined via cellular in vitro and in vivo assays, it seems still too early to draw a conclusion on ultimate efficacy of MSNs and MBGs in skin regeneration. In this regard, there are some concerns over the final fate of MSNs and MBGs in the wound site plus optimal dosages for achieving the best outcomes that deserve careful investigation in the future.

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Elastomeric biocomposite of silver-containing mesoporous bioactive glass and poly(1,8-octanediol citrate): Physiochemistry and in vitro antibacterial capacity in tissue engineering applications

Cited by 16 publications

References 66 publications

Self‐Healing Polyester Urethane Supramolecular Elastomers Reinforced with Cellulose Nanocrystals for Biomedical Applications

Self‐Healing Polyester Urethane Supramolecular Elastomers Reinforced with Cellulose Nanocrystals for Biomedical Applications

Bioelastomers: current state of development

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

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