Elastomeric and mechanically stiff nanocomposites from poly(glycerol sebacate) and bioactive nanosilicates

Kerativitayanan, Punyavee; Gaharwar, Akhilesh K.

doi:10.1016/j.actbio.2015.08.025

Cited by 59 publications

(56 citation statements)

References 53 publications

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“…To overcome these disadvantages, these inorganic nanoparticles are combined with polymeric networks to obtain polymeric nanocomposites . Within the polymeric chains, these nanoparticles interact physically or covalently to form a crosslinked network with multiple functionalities …”

Section: Introductionmentioning

confidence: 99%

Photocrosslinkable and elastomeric hydrogels for bone regeneration

Thakur

Xavier

Cross

et al. 2016

J Biomedical Materials Res

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Nanocomposite biomaterials are extensively investigated for cell and tissue engineering applications due their unique physical, chemical and biological characteristics. Here, we investigated the mechanical, rheological, and degradation properties of photocrosslinkable and elastomeric nanocomposite hydrogels from nanohydroxyapatite (nHAp) and gelatin methacryloyl (GelMA). The addition of nHAp resulted in a significant increase in mechanical stiffness and physiological stability. Cells readily adhere and proliferate on the nanocomposite surfaces. Cyclic stretching of cells on the elastomeric nanocomposites revealed that nHAp elicited a stronger alignment response in the direction of strain. In vitro studies highlight enhanced bioactivity of nanocomposites as determined by alkaline phosphate (ALP) activity. Overall, the elastomeric and photocrosslinkable nanocomposite hydrogels can be used for minimally invasive therapy for bone regeneration.

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Section: Introductionmentioning

confidence: 99%

Photocrosslinkable and elastomeric hydrogels for bone regeneration

Thakur

Xavier

Cross

et al. 2016

J Biomedical Materials Res

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“…The optimization of the melting point and the degree of cross‐linking by trying different curing time and by using different fatty acids could be the next step of this work. Our expectations are that these parameters will affect the shape memory efficiency (shape fixity and shape recovery ratio), the mechanical performances, and will help to control the degradation kinetic of these materials into a buffer …”

Section: Resultsmentioning

confidence: 99%

“…However, it has a relatively low Young's modulus, typically between 0.25 and 1.45 MPa, and needs to be cured for long periods (day) . To overcome this issue, new copolymers and nanocomposites elaboration strategies were developed . Another way to enhance this polymer is to give it new functionalities .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Shape Memory Poly(glycerol sebacate)-Stearate Polymer

Coativy

Misra

Mohanty

2016

Macromol. Mater. Eng.

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The polycondensation of sebacic acid with glycerol leads to the obtaining of poly(glycerol sebacate), a tough biocompatible polymer, which exhibits shape memory properties. Due to its low glass transition and melting temperatures, the temporary shape has to be kept below room temperature. In this study, the goal is to control the melting of the polyester by adding various amount of stearic acid into the synthesis in order to store the deformed material at room temperature. The reaction is carried out with microwave heating at 180 °C until a gel is obtained. The molar ratio of sebacic acid/glycerol is fixed to 1, while the molar ratio of stearic acid/glycerol varies between 0 and 0.5. The use of a molar ratio of 0.5 leads to the obtaining of materials having a melting temperature of 29 °C able to keep their temporary shape substantially at room temperature and to recover their initial shape in water bath at 37 °C by 85%.

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“…In bone regenerative therapy, mechanical stiffness of the scaffold can play an important role in maintaining the inner tissuereconstructive space for osteogenic cells such as osteoblasts 41,42) . Regenerative scaffolds should be designed to provide a highly porous structure for the stimulation of tissue ingrowth.…”

Section: Discussionmentioning

confidence: 99%

Dose effects of beta-tricalcium phosphate nanoparticles on biocompatibility and bone conductive ability of three-dimensional collagen scaffolds

et al. 2017

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Three-dimensional collagen scaffolds coated with beta-tricalcium phosphate (β-TCP) nanoparticles reportedly exhibit good bioactivity and biodegradability. Dose effects of β-TCP nanoparticles on biocompatibility and bone forming ability were then examined. Collagen scaffold was applied with 1, 5, 10, and 25 wt% β-TCP nanoparticle dispersion and designated TCP1, TCP5, TCP10, and TCP25, respectively. Compressive strength, calcium ion release and enzyme resistance of scaffolds with β-TCP nanoparticles applied increased with β-TCP dose. TCP5 showed excellent cell-ingrowth behavior in rat subcutaneous tissue. When TCP10 was applied, osteoblastic cell proliferation and rat cranial bone augmentation were greater than for any other scaffold. The bone area of TCP10 was 7.7-fold greater than that of non-treated scaffold. In contrast, TCP25 consistently exhibited adverse biological effects. These results suggest that the application dose of β-TCP nanoparticles affects the scaffold bioproperties; consequently, the bone conductive ability of TCP10 was remarkable.

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Elastomeric and mechanically stiff nanocomposites from poly(glycerol sebacate) and bioactive nanosilicates

Cited by 59 publications

References 53 publications

Photocrosslinkable and elastomeric hydrogels for bone regeneration

Photocrosslinkable and elastomeric hydrogels for bone regeneration

Synthesis of Shape Memory Poly(glycerol sebacate)-Stearate Polymer

Dose effects of beta-tricalcium phosphate nanoparticles on biocompatibility and bone conductive ability of three-dimensional collagen scaffolds

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