Elastic, Persistently Moisture-Retentive, and Wearable Biomimetic Film Inspired by Fetal Scarless Repair for Promoting Skin Wound Healing

Abstract

An efficient and available material for promoting skin regeneration is of great importance for public health, but it remains an elusive goal. Inspired by fetal scarless wound healing, we develop a wearable biomimetic film (WBMF) composed of hyaluronan (HA), vitamin E (VE), dopamine (DA), and βcyclodextrin (β-CD) that mimics the fetal context (FC) and fetal extracellular matrix (ECM) around the wound bed for dermal regeneration. First, the WBMF creates the FC of sterility, hypoxia, persistent moisture, and no secondary insults for wounds as the result of its seamless adhesion to the skin, optimum stress− stretch and high-cycle fatigue resistance matching the anisotropic tension of the skin, and water-triggered self-healing behavior. Thus, the WBMF modulates the early wound situation to minimize inflammatory response. In the meantime, the WBMF mimics the critical biological function of fetal ECM, inducing fibroblast migration, suppressing the overexpression of transforming growth factor β1, and mediating collagen synthesis, distribution, and reestablishment. As a result, the WBMF accelerates wound healing and gains a normal dermal collagen architecture, thereby restoring scarless appearance. Overall, the WBMF provides a new paradigm for promoting skin wound healing and may find broad utility for the field of regenerative medicine.

Engineering Platelet‐Rich Plasma Based Dual‐Network Hydrogel as a Bioactive Wound Dressing with Potential Clinical Translational Value

“…[ 42 ] Masson's trichrome (Masson) staining was further employed to assess the collagen deposition and organization of different treatment groups. [ 43 ] By observing the magnified region, bold and compact collagen fibers were found in the DN gel group. Moreover, these fibers displayed much more mature phenotype with regular orientation and collagen network topology.…”

Technological evolution of cyclodextrins in the pharmaceutical field

“…CD is used to enhance the solubility and availability of the active compound in the topical formulation [ 124 ]. Although the patenting behavior has remained without significant changes over time, the outcomes of recent research could change this trend as investigations range from ointments [ 125 ] to wearable biomimetic films for wound healing [ 126 ], including supramolecular gels [ 127 ] and nanosystems [ 128 ].…”

Injectable Enzyme‐Based Hydrogel Matrix with Precisely Oxidative Stress Defense for Promoting Dermal Repair of Burn Wound

“…The structural characterization of β‐CD‐6‐DA and β‐CD‐6‐DA‐HA as well as self‐embedding of VE in β‐CD‐6‐DA‐HA bulk had been reported in our previous work. [ 25 ] The formation of catechol‐Fe 3+ coordination was characterized using Raman spectra and UV–vis. In Figure 1a , the characteristic peaks at 556 and 641 cm −1 (assigned to the FeO bond stretch) were observed with the addition of Fe 3+ .…”

“…Synthesis and Fabrication: The β-CD-6-DA and β-CD-DA-HA were synthesized according to the previous work. [25] The details were described in the Supporting Information. The fabrication and characterization of catechol-Fe 3+ coordination complex hydrogels were described as follows.…”