Elastic liposome-mediated transdermal immunization enhanced the immunogenicity of P. falciparum surface antigen, MSP-119

Tyagi, Rajeev K.; Garg, Neeraj; Jadon, Rajesh S.; Sahu, Tejram; Katare, Om Prakash; Dalai, Sarat K.; Awasthi, Amit; Marepally, Srujan

doi:10.1016/j.vaccine.2015.06.054

Cited by 50 publications

(51 citation statements)

References 47 publications

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“…We have developed liposomal formulations of monensin that were shown to potentiate the toxicity of ricin in animal models (26). In malaria, merozoite surface protein 1 (MSP-1) entrapped in liposomes has been used as a vaccine (27). Liposomes containing glycolipids with terminal galactose or glucose on the surface when injected into Plasmodium berghei sporozoite-infected mice prevented the appearance of asexual stages and hepatic infection (28).…”

mentioning

confidence: 99%

Stearylamine Liposomal Delivery of Monensin in Combination with Free Artemisinin Eliminates Blood Stages of Plasmodium falciparum in Culture and P. berghei Infection in Murine Malaria

Rajendran

Rohra

Raza

et al. 2016

Antimicrob Agents Chemother

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The global emergence of drug resistance in malaria is impeding the therapeutic efficacy of existing antimalarial drugs. Therefore, there is a critical need to develop an efficient drug delivery system to circumvent drug resistance. The anticoccidial drug monensin, a carboxylic ionophore, has been shown to have antimalarial properties. Here, we developed a liposome-based drug delivery of monensin and evaluated its antimalarial activity in lipid formulations of soya phosphatidylcholine (SPC) cholesterol (

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mentioning

confidence: 99%

Stearylamine Liposomal Delivery of Monensin in Combination with Free Artemisinin Eliminates Blood Stages of Plasmodium falciparum in Culture and P. berghei Infection in Murine Malaria

Rajendran

Rohra

Raza

et al. 2016

Antimicrob Agents Chemother

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“…111 Tyagi et al suggested improved immunogenicity of carboxyl-terminal (19 kDa) fragments of merozoite surface protein-1 (PfMSP-119) of Plasmodium falciparum after subcutaneous administration using ELs. 112 Humoral and CMI responses were exhibited by the topical application of PfMSP-119-loaded EL. An alum-adsorbed PfMSP-119 solution and PfMSP-119-loaded conventional liposomes were administered intramuscularly and via a topical route, respectively, followed with comparisons against the vehicle as a control.…”

Section: Vaccines and Toxoidsmentioning

confidence: 99%

“…Fluorescence microscopy and histopathological assessment suggested major skin permeation and biodistribution to demonstrate efficient delivery of malarial antigen using ELs to immunocompetent Langerhans cells and lymphatics. 112 Several studies showed the application of antigencontaining occlusive patches to induce strong immune responses in an animal model as well as in human volunteers. 113,114 Moreover, the success of vaccination mainly depends on the nature (type) of the antigen and high doses used in occlusive patches.…”

Section: Vaccines and Toxoidsmentioning

confidence: 99%

Elastic liposomes as novel carriers: recent advances in drug delivery

Hussain¹,

Singh²,

Sharma

et al. 2017

IJN

134

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Elastic liposomes (EL) are some of the most versatile deformable vesicular carriers that comprise physiologically biocompatible lipids and surfactants for the delivery of numerous challenging molecules and have marked advantages over other colloidal systems. They have been investigated for a wide range of applications in pharmaceutical technology through topical, transdermal, nasal, and oral routes for efficient and effective drug delivery. Increased drug encapsulation efficiency, enhanced drug permeation and penetration into or across the skin, and ultradeformability have led to widespread interest in ELs to modulate drug release, permeation, and drug action more efficiently than conventional drug-release vehicles. This review provides insights into the versatile role that ELs play in the delivery of numerous drugs and biomolecules by improving drug release, permeation, and penetration across the skin as well as stability. Furthermore, it provides future directions that should ensure the widespread use of ELs across all medical fields.

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“…This in contrast to conventional liposomes and niosomes offers needle-free delivery of vaccines and an increased concentration of antibody titer which may suffice the need of systemic and mucosal immunity by provoking humoral and cellmediated branches of immune system. Moreover, these ultra-deformable carriers can easily overcome the skin barrier and efficiently deliver the antigenic payload [43,44].…”

Section: Transfersomesmentioning

confidence: 99%

“…Liposomal formulations have reportedly enhanced the immune response both at humoral and cell mediated of a vaccine formulation [44,51]. The adjuvant action of liposomes may be categorized as:…”

Section: Adjuvanticity Of Liposomesmentioning

confidence: 99%

Liposome-Mediated Immunosuppression Plays an Instrumental Role in the Development of “Humanized Mouse” to Study Plasmodium falciparum

Agrawal¹,

Vyas²,

Hafeji³

et al. 2017

Liposomes

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The material world has been getting prone toward infectious diseases, and therefore novel strategies should be devised to treat chronic infectious disorders. The translational biomedical research scientists made early attempts to develop mouse-human chimera (humanized mouse) through the reconstitution of immunodeficient mouse with engraftment of human cells and tissues. Although the humanized mouse proved to be an effective tool in understanding various diseases such as human malaria and hepatitis, however, drug administration, retention capacity of the administered drug, toxicity, and ethical constraints are some of the major issues and need to be objectively addressed. The "humanization" of immunodeficient mouse needs pharmacological immunomodulatory reagents to control the excessively recruited cells of monocytemacrophage lineage. Therefore, administration of liposome loaded with hydrophobic drug (clodronate) to induce selective apoptosis through "suicidal approach" in myeloid cells plays an instrumental role for controlling residual nonadaptive immune response of the host. Liposomes are spherical and hollow-structures consisting of lipid bilayer-and are used for the delivery of drug and vaccine candidates. The surfaceengineered liposomes (ligand anchored) are used for targeted and controlled delivery. Clodronate-loaded liposomes play a pivotal role in developing humanized mouse. This mouse holds relevance to study pathophysiology and immunopathology of human malaria parasite, P. falciparum. The liposomal delivery of clodronate administered in immunodeficient mice to modulate their innate immune system is an amenable strategy with the minimal/acceptable range of systemic toxicity.

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Elastic liposome-mediated transdermal immunization enhanced the immunogenicity of P. falciparum surface antigen, MSP-119

Cited by 50 publications

References 47 publications

Stearylamine Liposomal Delivery of Monensin in Combination with Free Artemisinin Eliminates Blood Stages of Plasmodium falciparum in Culture and P. berghei Infection in Murine Malaria

Stearylamine Liposomal Delivery of Monensin in Combination with Free Artemisinin Eliminates Blood Stages of Plasmodium falciparum in Culture and P. berghei Infection in Murine Malaria

Elastic liposomes as novel carriers: recent advances in drug delivery

Liposome-Mediated Immunosuppression Plays an Instrumental Role in the Development of “Humanized Mouse” to Study Plasmodium falciparum

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