This paper presents the results of an extensive review of the literature that relates to the interaction of domain-specific and strategic knowledge on academic performance. Our objectives in this review were to: (a) provide a critical analysis of that literature, (b) present hypotheses about the interaction between domain-specific and strategic knowledge as presented in the research, and (c) offer recommendations for future investigations on the interaction of domain-specific and strategic knowledge.Research in cognitive psychology during the past two decades has produced two undisputed findings about academic performance. First, those who know more about a particular domain generally understand and remember better than do those with only limited background knowledge (e.g., Chi, 1985;Glaser, 1984). Second, those who monitor and regulate their cognitive processing appropriately during task performance do better than those who do not engage in such strategic processing (e.g., Flavell, 1981;Garner, 1987). Although these two findings have been consistently supported in the research, there appears to be little understanding of how these two forms of knowledge interact during learning.Intuitively, it would seem that the effective and efficient learning in the classroom is dependent upon the continual orchestration of one's content and strategy knowledge. We might hypothesize, for example, that competent learners weigh their content knowledge against the demands of the task and then bring the appropriate form of strategic knowledge to bear on that task. As the learners' knowledge of the content relative to that task increases, then it is likely that the need for strategic behavior decreases. Alternatively, to the extent that strategies can only be executed in light of extensive domain knowledge, content knowledge and strategy use might covary.Although such hypotheses are plausible, we lack a synthesis of the literature relevant to the interaction of domain-specific and strategic knowledge against which