Elaboration and evaluation of an intraoral controlled release delivering system

Diarra, Mounibé; Pourroy, G.; Muster, D.; Zingraff, Matthew T.; Boymond, C.

doi:10.1016/s0142-9612(98)00070-2

Cited by 13 publications

(5 citation statements)

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“…Granules, tablets, [2][3][4][5] film coatings, [6][7][8] etc. are available, [9][10][11][12] and the matrix system is often prepared with the use of a polymer. 13,14) It is important to understand the entire release process to control drug release.…”

mentioning

confidence: 99%

Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules II. Effects of the Binder Solution on the Release Process

Fukui¹,

Fujii²,

Yonezawa

et al. 2004

CHEMICAL & PHARMACEUTICAL BULLETIN

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The release properties of phenylpropanolamine hydrochloride (PPA) from ethylcellulose (EC) matrix granules prepared by an extrusion granulation method were examined. The release process could be divided into two parts; the first and second stages were analyzed by applying square-root time law and cube-root law equations, respectively. The validity of the treatments was confirmed by the fitness of a simulation curve with the measured curve. In the first stage, PPA was released from the gel layer of swollen EC in the matrix granules. In the second stage, the drug existing below the gel layer dissolved and was released through the gel layer. The effect of the binder solution on the release from EC matrix granules was also examined. The binder solutions were prepared from various EC and ethanol (EtOH) concentrations. The media changed from a good solvent to a poor solvent with decreasing EtOH concentration. The matrix structure changed from loose to compact with increasing EC concentration. The preferable EtOH concentration region was observed when the release process was easily predictable. The time and release ratio at the connection point of the simulation curves were also examined to determine the validity of the analysis.

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confidence: 99%

Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules II. Effects of the Binder Solution on the Release Process

Fukui¹,

Fujii²,

Yonezawa

et al. 2004

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…1) Release properties of the matrix system were mathematically treated by Higuchi; the matrix system has often been used as a method to control drug release. As the matrix forms, granule, tablet, 2-5) film coating [6][7][8] and so on are available, [9][10][11][12] and the matrix system was often prepared by the use of a polymer. 13,14) However, it has been thought that mathematical analysis of the release process is insufficient, and that the entire release process is not obvious.…”

mentioning

confidence: 99%

Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules.

Fukui¹,

Fujii²,

Yonezawa

et al. 2002

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Thus, several release profiles as a function of time were obtained. These profiles were modelled according to kinetics of the first order of equation with determination coefficients close to 1 19,28,29 .…”

Section: In Vitro Release Study Using Phmentioning

confidence: 99%

O/W Pickering emulsion stabilized by magnesium carbonate particles for drug delivery systems

Dieng²,

Djiboune³

et al. 2023

J. Drug Delivery Ther.

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This study investigates the formulation of surfactant-free Pickering emulsions that release a drug at a specific pH to improve its oral bioavailability. The stabilizing particles composed of magnesium carbonate particles. Pickering oil-in-water emulsions stabilized with magnesium carbonate particles and encapsulating a hydrophobic drug model (ibuprofen) were formulated using a high-energy process with rotor-stator turbo mixer (IKA® T25 digital ultra-Turrax). The experimental approach explored the impact of all formulation parameters, dispersed phase and amount of magnesium carbonate particles on the physicochemical properties of Pickering emulsions. The O/W Pickering emulsion was characterized by a methylene blue test, pH and conductivity measurements, and droplet size determination. In addition, Pickering emulsions stabilized by magnesium carbonate particles have the advantage of being destabilized in acidic medium leading to the release of the active principle via the droplets. The acidic medium release study (pH equal to 1.2) showed ibuprofen release as a function of initial droplet loading and saturation concentration. In the simulated intestinal medium at pH equal to 6.8, we found a better release of ibuprofen from emulsions that already had saturation in an acid medium. Thus, the interest of these Pickering emulsions lies on the fact that their non-toxicity and magnesium carbonate particles allow destabilization of the emulsions and release of the drug. These emulsions not only protect patients from the side effects of acid-based drugs, but also contribute to increase the bioavailability of these acidic drugs. Keywords: emulsion -Pickering-magnesium carbonate- ibuprofen-oral bioavailability

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Elaboration and evaluation of an intraoral controlled release delivering system

Cited by 13 publications

References 0 publications

Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules II. Effects of the Binder Solution on the Release Process

Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules II. Effects of the Binder Solution on the Release Process

Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules.

O/W Pickering emulsion stabilized by magnesium carbonate particles for drug delivery systems

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