Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules.

Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules IV.1) Evaluation of the Controlled Release Properties for in Vivo and in Vitro Release Systems

“…1,5,6) Phenylpropanolamine hydrochloride (PPA) (Powder, Alps Pharmaceutical Ind. Co., Ltd., Gifu), ethylcellulose 10 cps (EC) (ETHOCEL STD 10 cps, DOW Chemical, Tokyo), Nonpalel 103 (NP) (Sugar cube, Freund Industrial Co., Ltd., Tokyo), Talc, Polyethylenglycol (PEG), Fe 2 O 3 and 90% ethanol (EtOH) (Wako Pure Chemical Industries, Ltd., Osaka) were used.…”

“…Equipment The equipment described in the previous paper was used. 1,5,6) A high shear granulator (High Speed Mixer, LFS-GS-5, volume 5.0 l, Fukae Ind. Co., Ltd., Hyogo) and extrusion granulator (Granulator machine type of LAB, KAR-130, Tsutsui Physics and Chemistry Apparatus Co., Ltd., Tokyo) were used for granulation.…”

“…2,3) The release properties of the matrix system were mathematically assessed by Higuchi,4) and matrix systems have often been used as a method of controlled drug release; however, it was considered that the mathematical analysis of the release process was insufficient, because the equation can not explain the entire release process. 1,5,6) In previous papers, the release process was divided into two stages to understand the entire release process and these were analyzed using a combination of the square-root time law and cube-root law equations. 1,5,6) It was concluded that predicting drug release properties using this analysis was useful.…”

“…1,5,6) In previous papers, the release process was divided into two stages to understand the entire release process and these were analyzed using a combination of the square-root time law and cube-root law equations. 1,5,6) It was concluded that predicting drug release properties using this analysis was useful.…”

Influence of Swallowing Aids on the Adsorption and Palatability of Kremezin

“…Fukui et al has reported on the physicochemical characteristics of jellies (viscosity, strength, loss of water content), and their effects on swallowing. 18) In this study, both the jelly product and a paste product had higher viscosities than TROMELIN ® Gra. and water (control).…”