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Abstract

Results from ROC curves of items from two scales, the Autism Diagnostic Interview (ADI) and Autism Diagnostic Interview-Revised (ADI-R), operationalizing DSM-IV criteria for autism are presented for 319 autistic and 113 other subjects from 8 international autism centers. Analyses indicate that multiple items were necessary to attain adequate sensitivity and specificity if samples with varying levels of language were considered separately. Although considering only current behavior was generally sufficient when a combination cutoff and additive model was employed, predictive power was highest when history was taken into account. A single set of criteria, as operationalized by individually structured questions in the ADI/ADI-R, was effective in differentiating autism from mental handicap and language impairment in subjects with a range of chronological ages and developmental levels.

Examination of Aggression and Self-injury in Children with Autism Spectrum Disorders and Serious Behavioral Problems

“…38,47,48 The interview inquires about reciprocal social interaction, communication, restricted interests and repetitive behavior. In these RUPP Autism Network trials, interviews were administered and scored by clinicians trained to reliability.…”

Gastrointestinal Symptoms in a Sample of Children with Pervasive Developmental Disorders

“…Autism Diagnostic Interview-Revised (ADI-R) (Lord et al 1997) Training on the ADI-R was rigorous, involving didactic sessions, supervised administration of a live interview, reliable rating of a taped interview, and demonstrated competence in at least three taped interviews by the new rater.…”

Dimensional Structure of the Autism Phenotype: Relations Between Early Development and Current Presentation

“…The expression of autistic symptoms was assessed by the German version of the Autism Diagnostic Observation Scale (ADOS-G; Lord et al 2000;Rühl et al 2004) and a semi-structured autism specific parent interview (ADI-R; Lord et al 1997;Bölte et al 2006); this in-depth assessment was conducted by trained examiners (I. K.-B., M. G).…”

“…Table 2 includes studies concerning the dimensional structure of the domain of restricted, repetitive behavior and interests. The majority of these studies are based on the data from the Autism Diagnostic Interview-Revised (ADI-R) (Lord et al 1994(Lord et al , 1997. The ADI-R is a structured interview with the caregivers of an autistic child.…”

“…But this is circular argumentation: The algorithm items of the ADI-R were selected due to fact that they most ''closely depicted the specific abnormalities described in the clinical descriptions and diagnostic guidelines from the DSM-IV and ICD-10'' (Lord et al 1994). Another limitation is given by the fact that for the development of the algorithm of ADI-R ''diagnostically borderline cases had been excluded'' and ''subjects with PDD-NOS were grouped with other nonautistic subjects'' (Lord et al 1997). So questions arise whether the results are valid for the whole spectrum especially for the high functioning subgroup.…”