Dimensional Structure of the Autism Phenotype: Relations Between Early Development and Current Presentation

Kamp‐Becker, Inge; Ghahreman, Mardjan; Smidt, Judith; Remschmidt, Helmut

doi:10.1007/s10803-008-0656-5

Cited by 47 publications

(41 citation statements)

References 37 publications

(49 reference statements)

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“…Two of these studies 65,72 found kappa statistics to range from 0.60 and 0.80 on all items, and Lord et al 65 found 92% agreement for autism/not autism. However, the lack of methodological information regarding these analyses led the study by Kamp-Becker et al 72 to be judged as of poor methodological quality. Lord et al 50 presented inter-rater kappa statistics for each module separately and found a mean weighted kappa statistic of 0.78 for module 1, 0.70 for module 2 and 0.65 for module 3.…”

Section: Autism Diagnostic Observation Schedule-genericmentioning

confidence: 99%

“…Seven papers 50,65,70,[72][73][74][75] considering measurement properties of the ADOS-G were reviewed. The original study 50 assessed internal consistency.…”

Section: Autism Diagnostic Observation Schedule-genericmentioning

confidence: 99%

“…For the social communication totals, Cronbach's alpha coefficients were high (0.91-0.94) for modules 1-3; however, as the sample size included in each of the unidimensionality analyses was small, the study was judged poor. Three studies 50,65,72 assessed inter-rater reliability. Two of these studies 65,72 found kappa statistics to range from 0.60 and 0.80 on all items, and Lord et al 65 found 92% agreement for autism/not autism.…”

Section: Autism Diagnostic Observation Schedule-genericmentioning

confidence: 99%

“…Three papers 50,72,73 assessed structural validity. Lord et al 50 found almost all social and communication items loaded highly on one factor in each module, accounting for between 72% and 78% (modules 1 and 2), and 52% and 53% (modules 3 and 4) of the variance, leading to the adoption of an algorithm total of social-communication items.…”

Section: Systematic Review Of Measurement Properties Of Toolsmentioning

confidence: 99%

“…However, the small sample size (79 participants and 29 ratings in module 1, 55 children and 28 ratings in module 2, and 59 participants and 28 ratings in module 3) led this study to be judged to be of poor methodological quality. Kamp-Becker et al 72 assessed structural validity and found in a three-factor solution the amount of variance explained was 47%, in the four-factor solution it was 52% and the five-factor solution explained 57% of variance. The third paper 73 investigated both the original algorithm structure and the new algorithms, compatible with DSM-5.…”

Section: Systematic Review Of Measurement Properties Of Toolsmentioning

confidence: 99%

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Systematic review of tools to measure outcomes for young children with autism spectrum disorder

McConachie

Parr

Glod

et al. 2015

Health Technology Assessment

227

261

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BackgroundThe needs of children with autism spectrum disorder (ASD) are complex and this is reflected in the number and diversity of outcomes assessed and measurement tools used to collect evidence about children’s progress. Relevant outcomes include improvement in core ASD impairments, such as communication, social awareness, sensory sensitivities and repetitiveness; skills such as social functioning and play; participation outcomes such as social inclusion; and parent and family impact.ObjectivesTo examine the measurement properties of tools used to measure progress and outcomes in children with ASD up to the age of 6 years. To identify outcome areas regarded as important by people with ASD and parents.MethodsThe MeASURe (Measurement in Autism Spectrum disorder Under Review) research collaboration included ASD experts and review methodologists. We undertook systematic review of tools used in ASD early intervention and observational studies from 1992 to 2013; systematic review, using the COSMIN checklist (Consensus-based Standards for the selection of health Measurement Instruments) of papers addressing the measurement properties of identified tools in children with ASD; and synthesis of evidence and gaps. The review design and process was informed throughout by consultation with stakeholders including parents, young people with ASD, clinicians and researchers.ResultsThe conceptual framework developed for the review was drawn from the International Classification of Functioning, Disability and Health, including the domains ‘Impairments’, ‘Activity Level Indicators’, ‘Participation’, and ‘Family Measures’. In review 1, 10,154 papers were sifted – 3091 by full text – and data extracted from 184; in total, 131 tools were identified, excluding observational coding, study-specific measures and those not in English. In review 2, 2665 papers were sifted and data concerning measurement properties of 57 (43%) tools were extracted from 128 papers. Evidence for the measurement properties of the reviewed tools was combined with information about their accessibility and presentation. Twelve tools were identified as having the strongest supporting evidence, the majority measuring autism characteristics and problem behaviour. The patchy evidence and limited scope of outcomes measured mean these tools do not constitute a ‘recommended battery’ for use. In particular, there is little evidence that the identified tools would be good at detecting change in intervention studies. The obvious gaps in available outcome measurement include well-being and participation outcomes for children, and family quality-of-life outcomes, domains particularly valued by our informants (young people with ASD and parents).ConclusionsThis is the first systematic review of the quality and appropriateness of tools designed to monitor progress and outcomes of young children with ASD. Although it was not possible to recommend fully robust tools at this stage, the review consolidates what is known about the field and will act as a benchmark for future developments. With input from parents and other stakeholders, recommendations are made about priority targets for research.Future workPriorities include development of a tool to measure child quality of life in ASD, and validation of a potential primary outcome tool for trials of early social communication intervention.Study registrationThis study is registered as PROSPERO CRD42012002223.FundingThe National Institute for Health Research Health Technology Assessment programme.

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Section: Autism Diagnostic Observation Schedule-genericmentioning

confidence: 99%

“…Seven papers 50,65,70,[72][73][74][75] considering measurement properties of the ADOS-G were reviewed. The original study 50 assessed internal consistency.…”

Section: Autism Diagnostic Observation Schedule-genericmentioning

confidence: 99%

Section: Autism Diagnostic Observation Schedule-genericmentioning

confidence: 99%

Section: Systematic Review Of Measurement Properties Of Toolsmentioning

confidence: 99%

Section: Systematic Review Of Measurement Properties Of Toolsmentioning

confidence: 99%

See 3 more Smart Citations

Systematic review of tools to measure outcomes for young children with autism spectrum disorder

McConachie

Parr

Glod

et al. 2015

Health Technology Assessment

227

261

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Outcomes in Adults With Autism Spectrum Disorders

Howlin

2014

Handbook of Autism and Pervasive Developmental Disorders, Fourth Edition

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Even with improved diagnosis and treatment in recent years, studies show that less than 20\% of individuals with autism spectrum disorder (ASD) are considered to have a Good/Very Good outcome in adulthood. Variables affecting long‐term prognosis include IQ, development of some useful language by age 5 or 6, severity of autistic symptoms, early intervention, and access to support networks in adulthood. Specific concerns for adults with ASD are mental health, mortality and life expectancy, deterioration with age, and what constitutes a good quality of life.

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Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high‐functioning level

Wermter

Kamp‐Becker

Hesse

et al. 2010

American J of Med Genetics Pt B

Self Cite

152

109

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An increasing number of animal studies advert to a substantial role of the neuropeptide oxytocin in the regulation of social attachment and affiliation. Furthermore, animal studies showed anxiety and stress-reduced effects of oxytocin. First human studies confirm these findings in animal studies and implicate a crucial role of oxytocin in human social attachment behavior and in social interactions. Thus, the oxytocin system might be involved in the impairment of social interaction and attachment in autism spectrum disorders (ASD). The human oxytocin receptor gene (OXTR) represents a plausible candidate gene for the etiology of ASD. To analyze whether genetic variants in the OXTR gene are associated with ASD we performed family-based single-marker and haplotype association analyses with 22 single nucleotide polymorphisms (SNPs) in the OXTR and its 5' region in 100 families with autistic disorders on high-functioning level (Asperger syndrome (AS), high-functioning autism (HFA), and atypical autism (AA)). Single-marker and haplotype association analyses revealed nominally significant associations of one single SNP and one haplotype with autism, respectively. Furthermore, employing a "reverse phenotyping" approach, patients carrying the haplotype associated with autism showed nominally significant impairments in comparison to noncarriers of the haplotype in items of the Autism Diagnostic Interview-Revised algorithm describing aspects of social interaction and communication. In conclusion, our results implicate that genetic variation in the OXTR gene might be relevant in the etiology of autism on high-functioning level.

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Dimensional Structure of the Autism Phenotype: Relations Between Early Development and Current Presentation

Cited by 47 publications

References 37 publications

Systematic review of tools to measure outcomes for young children with autism spectrum disorder

Systematic review of tools to measure outcomes for young children with autism spectrum disorder

Outcomes in Adults With Autism Spectrum Disorders

Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high‐functioning level

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