El salbutamol mejora la contractilidad diafragmática en la obstrucción crónica de la vía aérea

Angulo, Martín; Taranto, Eliseo; Soto, Juan Pablo; Malacrida, Leonel; Nin, Nicolás; Hurtado, Francisco Javier; Píriz, Héctor

doi:10.1016/j.arbres.2008.09.007

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…For instance, possible effects on the respiratory muscle strength have to be considered. It is well established that beta agonists improve the performance of skeletal muscles [22] and also positively affect respiratory muscle strength [23,24]. The opposite effect by BBL medication is suggested by a recent study from Frankenstein et al performed in patients with chronic heart failure [25].…”

Section: Discussionmentioning

confidence: 99%

High blood pressure, antihypertensive medication and lung function in a general adult population

et al. 2011

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BackgroundSeveral studies showed that blood pressure and lung function are associated. Additionally, a potential effect of antihypertensive medication, especially beta-blockers, on lung function has been discussed. However, side effects of beta-blockers have been investigated mainly in patients with already reduced lung function. Thus, aim of this analysis is to determine whether hypertension and antihypertensive medication have an adverse effect on lung function in a general adult population.MethodsWithin the population-based KORA F4 study 1319 adults aged 40-65 years performed lung function tests and blood pressure measurements. Additionally, information on anthropometric measurements, medical history and use of antihypertensive medication was available. Multivariable regression models were applied to study the association between blood pressure, antihypertensive medication and lung function.ResultsHigh blood pressure as well as antihypertensive medication were associated with lower forced expiratory volume in one second (p = 0.02 respectively p = 0.05; R2: 0.65) and forced vital capacity values (p = 0.01 respectively p = 0.05, R2: 0.73). Furthermore, a detailed analysis of antihypertensive medication pointed out that only the use of beta-blockers was associated with reduced lung function, whereas other antihypertensive medication had no effect on lung function. The adverse effect of beta-blockers was significant for forced vital capacity (p = 0.04; R2: 0.65), while the association with forced expiratory volume in one second showed a trend toward significance (p = 0.07; R2: 0.73). In the same model high blood pressure was associated with reduced forced vital capacity (p = 0.01) and forced expiratory volume in one second (p = 0.03) values, too.ConclusionOur analysis indicates that both high blood pressure and the use of beta-blockers, but not the use of other antihypertensive medication, are associated with reduced lung function in a general adult population.

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Section: Discussionmentioning

confidence: 99%

High blood pressure, antihypertensive medication and lung function in a general adult population

et al. 2011

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“…Muscle contractile properties were studied in vitro under isometric conditions in sham, LPS-d3, and LPS-d7 mice (Angulo et al, 2009). Muscles were surgically excised taking special care not to stretch or damage the fibers.…”

Section: Muscle In Vitro Contractilitymentioning

confidence: 99%

Peripheral and respiratory muscle impairment during murine acute lung injury

Angulo

Vacca

Rodríguez

et al. 2022

Physiological Reports

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Acute respiratory distress syndrome is associated with skeletal muscle compromise, which decreases survival and impairs functional capacity. A comparative analysis of peripheral and respiratory muscles' atrophy and dysfunction in acute lung injury (ALI) has not been performed. We aimed to evaluate diaphragmatic and peripheral muscle mass and contractility in an ALI animal model. ALI was induced in C57BL/6 mice by intratracheal lipopolysaccharides instillation.Muscle mass and in vitro contractility were evaluated at different time points in hindlimb soleus (slow-twitch) and extensor digitorum longus (EDL, fast-twitch), as well as in the main respiratory muscle diaphragm. Myogenic precursor satellite cell-specific transcription factor Pax7 expression was determined by Western blot. Lung injury was associated with atrophy of the three studied muscles, although it was more pronounced and persistent in the diaphragm. Specific contractility was reduced during lung injury in EDL muscle but restored by the time lung injury has resolved. Specific force was not affected in soleus and diaphragm.A persistent increase in Pax7 expression was detected in diaphragm and EDL muscles after induction of ALI, but not in soleus muscle. Different peripheral and respiratory skeletal muscles are distinctly affected during the course of ALI. Each of the studied muscles presented a unique pattern in terms of atrophy development, contractile dysfunction and Pax7 expression.

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Archivo de Archivos: 2009

Granda‐Orive

Roig-Vázquez

2010

Archivos de Bronconeumología

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El salbutamol mejora la contractilidad diafragmática en la obstrucción crónica de la vía aérea

Cited by 4 publications

References 30 publications

High blood pressure, antihypertensive medication and lung function in a general adult population

High blood pressure, antihypertensive medication and lung function in a general adult population

Peripheral and respiratory muscle impairment during murine acute lung injury

Archivo de Archivos: 2009

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