EKG-Veränderungen bei Patienten mit chronischen Nichttumorschmerzen

Peuckmann‐Post, Vera; Eickhoff, Roman; Becker, Markus; Laage, D. von der

doi:10.1007/s00482-012-1204-y

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Atrial fibrillation, the most common abnormal heart rhythm in adults, can lead to formation of clots (most commonly in the left atrial appendage) and subsequent stroke [85][86][87] . Electrocardiogram abnormalities, particularly atrial fibrillation, have been linked to chronic pain 88,89 , and with physiological stress associated with chronic illness and major surgery 90,91 . Chronic pain has also been associated with higher risk of myocardial infarction, death due to cardiovascular event, heart failure, and stroke 92 .…”

Section: Tissue Enrichment Of Nociplastic Type Pain Genes Highlights ...mentioning

confidence: 99%

Chronic Overlapping Pain Conditions and Nociplastic Pain

Johnston

Signer

Huckins

2023

Preprint

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Background: Chronic Overlapping Pain Conditions (COPCs) are a subset of chronic pain conditions commonly comorbid with one another and more prevalent in women and assigned female at birth (AFAB) individuals. Pain experience in these conditions may better fit with a new mechanistic pain descriptor, nociplastic pain, and nociplastic type pain may represent a shared underlying factor among COPCs. Methods: We applied GenomicSEM common-factor genome wide association study (GWAS) and multivariate transcriptome-wide association (TWAS) analyses to existing GWAS output for six COPCs in order to find genetic variation associated with nociplastic type pain, followed by genetic correlation (linkage-disequilibrium score regression), gene-set and tissue enrichment analyses. Results: We found 24 independent single nucleotide polymorphisms (SNPs), and 127 unique genes significantly associated with nociplastic type pain, and showed nociplastic type pain to be a polygenic trait with significant SNP-heritability. We found significant genetic overlap between multisite chronic pain and nociplastic type pain, and to a smaller extent with rheumatoid arthritis. Tissue enrichment analyses highlighted cardiac and thyroid tissue, and gene set enrichment analyses emphasized potential shared mechanisms in cognitive, personality, and metabolic traits and nociplastic type pain along with distinct pathology in migraine and headache. Conclusions: We use a well-powered network approach to investigating nociplastic type pain using existing COPC GWAS output, and show nociplastic type pain to be a complex, heritable trait, in addition to contributing to understanding of potential mechanisms in development of nociplastic pain.

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Section: Tissue Enrichment Of Nociplastic Type Pain Genes Highlights ...mentioning

confidence: 99%

Chronic Overlapping Pain Conditions and Nociplastic Pain

Johnston

Signer

Huckins

2023

Preprint

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Muscarinic receptor regulation of chronic pain-induced atrial fibrillation

Gong

Ding

Liang

et al. 2022

Front. Cardiovasc. Med.

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Atrial fibrillation (AF), one of the most common arrhythmias, is associated with chronic emotional disorder. Chronic pain represents a psychological instability condition related to cardiovascular diseases, but the mechanistic linkage connecting chronic pain to AF occurrence remains unknown. Wild-type C57BL/6J male mice were randomly divided into sham and chronic pain groups. Autonomic nerve remodeling was reflected by the increased atrial parasympathetic tension and muscarinic acetylcholine receptor M2 expression. AF susceptibility was assessed through transesophageal burst stimulation in combination with electrocardiogram recording and investigating AERP in Langendorff perfused hearts. Our results demonstrated the elevated protein expression of muscarinic acetylcholine receptor M2 in the atria of mice subjected to chronic pain stress. Moreover, chronic pain induced the increase of atrial PR interval, and atrial effective refractory periods as compared to the sham group, underlying the enhanced susceptibility of AF. Thus, autonomic cholinergic nerve may mediate mice AF in the setting of chronic pain.

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EKG-Veränderungen bei Patienten mit chronischen Nichttumorschmerzen

Abstract: The prevalence of abnormal ECG recordings should be considered in the pain management of these patients. General ECG screening in this population should be discussed. Future studies should examine a larger population to identify potential risk factors (e.g., medication).

Cited by 2 publications

References 19 publications

Chronic Overlapping Pain Conditions and Nociplastic Pain

Chronic Overlapping Pain Conditions and Nociplastic Pain

Muscarinic receptor regulation of chronic pain-induced atrial fibrillation

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