Abstract:Background: Chronic Overlapping Pain Conditions (COPCs) are a subset of chronic pain conditions commonly comorbid with one another and more prevalent in women and assigned female at birth (AFAB) individuals. Pain experience in these conditions may better fit with a new mechanistic pain descriptor, nociplastic pain, and nociplastic type pain may represent a shared underlying factor among COPCs. Methods: We applied GenomicSEM common-factor genome wide association study (GWAS) and multivariate transcriptome-wide … Show more
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