Eiwei�chemische und immunologische Untersuchungen bei Hautkranken

Brehm, G.

doi:10.1007/bf00522553

Cited by 10 publications

(2 citation statements)

References 106 publications

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“…There is a tendency of the serum albumin to diminish and the alpha 2 and gamma globulins tend to increase. The serum transferrin diminishes (Ippen, 1963 ;Brehm, 1965 ;VoUmer, 1965). Most authorities (Harber, 1965) consider the bromsulphothalein retention test to be the most valuable to follow the changes of the functional state of the liver in this condition.…”

Section: The Classification Of the Cutaneous Porphyriasmentioning

confidence: 99%

Some Clinical and Pathogenetic Peoblems of Poephybia

Kocsard¹

1966

Australas J Dermatol

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The light sensitivity of porphyria eutanea predisposes to an early ageing of the skin. In Atistralia where there is a high incidence of early ageing of the exposed shin, porphyria might easily remain undiagnosed.The classical manifestation of porphyria cutanea tarda, the traumatic blistering, is an intermittent phenomenon and appears only over exposed skin areas showing the clinical manifestations of actinic elastosis. The changes of the fine elastic fibres of the dermal papillae and the damaged basement membrane of the dermo-epidermal junetion predisposes the aged skin to dermo-epidermal blister formation. The ultimate cause of the blistering is not photo-sensitivity, but probably a toxic factor which further damages the dermo-epidermal connections without the intervention of inflammatory phenomena.Porphyria will cause blistering in aged shin, but various non-specific, non-diagnostic manifestations, due to photo-sensitivity occur in shin areas without elastotic changes.Cutaneous porphyria, as has been recently stressed by Donald et al., is not rare in Austraha. In recent years there have been very few clinical meetings of dermatology without presentation of examples of it. The condition, however, might have an even higher incidence than our clinical studies would indicate. As well as patients with classical skin manifestations which may be associated with the underlying biochem^ical deviations, there are many others in latency or remission.A relatively early ageing of the skin due to the increased sensitivity to sunlight attributed to the porphyrins, is one of the basic changes. Unfortunately early ageing of the exposed skin has such a high incidence in Austraha that it is not an indication to perform biochemical studies for the detection of porphyria. Eor example, the incidence of nodular elastoidosis of Favre and Eacouchot is so high in our geriatric age group that we would not think of the existence of porphyria to explain its presence in the individual case. In two patients of Ippen, this was the skin condition leading to the diagnosis of porphyria cutanea tarda (P.C.T.). In other countries a weatherbeaten skin with superficial, depigmented, irregular scarring would be at once suggestive of P.C.T. In Austraha the most likely explanation of this kind of changes on the face and hands is that they were produced by treatment of actinic keratoses and rodent carcinomas.There is an easy and inexpensive method to detect the real incidence of porphyria hepatica (P.H.) in a community. This consists in viewing the cut slices of the liver at autopsies under the Wood's light. The porphyric liver will show extensive fluorescence if exposed to this type of radiation. Using this method at 1300 unselected post-mortems, Ippen found a diffuse liver fluorescence in 14 and a more circumscribed tjrpe of fluorescence in more than 60 cases. The incidence of P.H. in his case material could be anything between 1% and 5%. Bielicki of Prague, very recently found in a similar study that 0-76% of the livers have shown fluorescence at aut...

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Section: The Classification Of the Cutaneous Porphyriasmentioning

confidence: 99%

Some Clinical and Pathogenetic Peoblems of Poephybia

Kocsard¹

1966

Australas J Dermatol

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“…In der Elektrophorese werden regelmässig die Albumine ver mindert und die Globuline vermehrt gefunden. Nach der Literatur [4] werden in der Immunelektophorese die YlM-Immunglobuline sowie Coeruloplasmin als erhöht und das Transferrin als erniedrigt angegeben. Unsere eigenen Untersuchungen zeigten aber noch weitere Veränderungen:…”

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Zur Klinik der Acrodermatitis chronica atrophicans Pick-Herxheimer unter besonderer Berücksichtigung der Immunelektrophorese

Goor¹,

Schwarz-Speck²

1972

Dermatology

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Acrodermatitis chronica atrophicans gives a typical change in the composition of the serumproteins. This could be verified in 54 cases during the years 1960–1970 at the Dermatological University Clinic Zurich. Comparative investigations of immunoelectrophoresis in 11 patients before and after treatment in the course of 1 to 4 years partially confirmed these findings, they however showed other typical changes which remained for a long time after successful clinical treatment.

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Entwicklungslinien der Sklerodermieforschung in der Gegenwart

Korting¹,

Holzmann²

1966

Ergebnisse Der Inneren Medizin Und Kinderheilkunde

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Eiwei�chemische und immunologische Untersuchungen bei Hautkranken

Cited by 10 publications

References 106 publications

Some Clinical and Pathogenetic Peoblems of Poephybia

Some Clinical and Pathogenetic Peoblems of Poephybia

Zur Klinik der Acrodermatitis chronica atrophicans Pick-Herxheimer unter besonderer Berücksichtigung der Immunelektrophorese

Entwicklungslinien der Sklerodermieforschung in der Gegenwart

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