Einwirkung organischer Flüssigkeiten auf die Haut

Oettel, Hansjürgen

doi:10.1007/bf02112310

Cited by 55 publications

(4 citation statements)

References 16 publications

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“…The odour threshold for cyclohexane is given as 0.5 ml/m 3 (Alibaew 1970). Liquid cyclohexane is mildly irritating on human skin (Oettel 1936).…”

Section: Effects In Manmentioning

confidence: 99%

Cyclohexane [MAK Value Documentation, 1999]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 13 (1999) The article contains sections titled: Toxic Effects and Mode of Action Mechanism of Action Toxicokinetics and Metabolism Effects in Man Animal Experiments and in vitro Studies Acute toxicity Subacute, subchronic and chronic toxicity Effects on skin and mucous membranes Reproductive and developmental toxicity Genotoxicity Carcinogenicity Manifesto (MAK value/classification) Estimation of the spermatotoxic effect in man Derivation of the MAK value

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“…The odour threshold for cyclohexane is given as 0.5 ml/m 3 (Alibaew 1970). Liquid cyclohexane is mildly irritating on human skin (Oettel 1936).…”

Section: Effects In Manmentioning

confidence: 99%

Cyclohexane [MAK Value Documentation, 1999]

2012

The MAK‐Collection for Occupational Health and Safety

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“…2 Human skin irritation following contact with pentane has been reported with immediate irritation, swelling, and pigmentation followed by blister formation. 3 Rats given gavage doses of either 500 or 2,000 mg/kg pentane 5 days/week for 4 weeks had lower kidney weights but no other nephrotoxic signs. 4 This study was quite limited in scope.…”

Section: Introductionmentioning

confidence: 98%

Repeated Exposure Inhalation Study of Pentane in Rats

Stadler

O'Neill

Elliott³

et al. 2001

Drug and Chemical Toxicology

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Pentane (CAS No. 109-66-0) is a chemical being used as a co-solvent in a polymer production facility with potential for inhalation exposure in humans. To assess the toxicity of pentane, groups of 10 male rats each were exposed by inhalation, 6 hr/day, 5 days/week for 2 weeks to either 0 (control), 1,000, 3,000 or 10,000 ppm. Five rats per group were killed following the 10th exposure; the remaining 5/group were killed after a 14-day post-exposure recovery period. Parameters investigated were clinical signs of toxicity, functional behavior, body weights, clinical pathology, and gross and microscopic pathology including organ weights. No unusual clinical observations were seen in the pentane-treated rats, and body weights were not altered. Test rats generally exhibited normal behavioral responses in the functional observational battery. Increases in serum calcium and phosphorus concentrations were seen in rats exposed to either 3,000 or 10,000 ppm. These were reversible during the 2-week recovery period. No other clinical pathology changes were observed and no pentane-related tissue pathology was seen in any of the groups. The no-observed-adverse-effect level was 1,000 ppm with reversible clinical pathology changes produced at 3,000 and 10,000 ppm.

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“…In a study with five test persons, a burning sensation and the development of erythema, hyperaemia and weals was reported after 3 minutes contact with undiluted chlorobenzene; 12 hours later blisters were observed. After contact for 5 hours the sequelae were only slightly more severe (Oettel 1936, cited from BUA 1990. Another publication reports that contact with 5 % chlorobenzene in olive oil leads to the formation of acneiform skin eruptions (Fisher 1973).…”

Section: Effects On Skin and Mucous Membranesmentioning

confidence: 99%

Chlorobenzene [MAK Value Documentation, 1999]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 12 (1999) The article contains sections titled: Toxic Effects and Mode of Action Mechanism of Action Toxicokinetics and Metabolism Absorption Distribution Metabolism Elimination Effects in Man Single exposures Repeated exposure Effects on skin and mucous membranes Animal Experiments and in vitro Studies Acute toxicity Subacute, subchronic and chronic toxicity Effects on skin and mucous membranes Allergenic effects Reproductive and developmental toxicity Genotoxicity Carcinogenicity Other effects Manifesto (MAK value, classification)

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Einwirkung organischer Flüssigkeiten auf die Haut

Cited by 55 publications

References 16 publications

Cyclohexane [MAK Value Documentation, 1999]

Cyclohexane [MAK Value Documentation, 1999]

Repeated Exposure Inhalation Study of Pentane in Rats

Chlorobenzene [MAK Value Documentation, 1999]

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