Eintauchen in den Sequenzraum der Thiolacton‐Präzisionspolymere: eine kombinatorische Strategie zur Identifizierung funktionaler Domänen

Der Zugang zu Sequenzen fürf unktionale Präzisionspolymere kann aufgrund der Reihenfolge von Seitengruppenfunktionen eines bekannten Peptids ermçglicht werden. Die direkte Übersetzung einer Peptidsequenz, die zuvor als Solubilisator fürd en Photosensibilisator meta-Tetra(hydroxyphenyl)chlorin selektiert wurde, in zwei verschiedene Präzisionspolymere wird gezeigt. Die resultierenden peptidmimeti-schenF ormulierungsadditive auf Basis monodisperser Oligo(N-substituierter-acrylamide) und Oligo(2-substituiertera-hydroxycarbonsäuren) weisen scharf definierte Sequenz-Eigenschafts-Beziehungen auf und übertreffen in einigen Fällen die Wirkstoffkapazitätu nd Freisetzungskinetiken des peptidischen Vorbilds,w obei Solubilisatoren mit bis zu 40 % hçherer Beladbarkeit und 27-fachs chnellerer Freisetzunge rreicht werden.

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Von Peptiden lernen: eine Strategie für das Design funktionaler Präzisionspolymer‐Sequenzen

Maron

Swisher

Haven

et al. 2019

Angewandte Chemie

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Iron‐Catalysed Radical Polymerisation by Living Bacteria

et al. 2020

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The ability to harness cellular redox processes for abiotic synthesis might allow the preparation of engineered hybrid living systems. Towards this goal we describe a new bacteria‐mediated iron‐catalysed reversible deactivation radical polymerisation (RDRP), with a range of metal‐chelating agents and monomers that can be used under ambient conditions with a bacterial redox initiation step to generate polymers. Cupriavidus metallidurans, Escherichia coli, and Clostridium sporogenes species were chosen for their redox enzyme systems and evaluated for their ability to induce polymer formation. Parameters including cell and catalyst concentration, initiator species, and monomer type were investigated. Water‐soluble synthetic polymers were produced in the presence of the bacteria with full preservation of cell viability. This method provides a means by which bacterial redox systems can be exploited to generate “unnatural” polymers in the presence of “host” cells, thus setting up the possibility of making natural–synthetic hybrid structures and conjugates.

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Homogeneous Synthesis of Monodisperse Sequence‐Defined Conjugated Oligomers by Temperature Cycling

Zhao

et al. 2022

Angewandte Chemie

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Sequence‐defined synthetic oligomers and polymers provide unprecedented opportunities for polymer chemists to finely control properties such as chain folding, self‐assembly, and optoelectronic performance of materials. However, absolute control over both chain‐length and monomer sequence has been a long‐standing “grand challenge” for decades. Herein, we report a novel strategy to synthesize monodisperse sequence‐defined conjugated oligomers in a homogeneous manner by temperature cycling, thereby achieving single‐monomer precision in conjugated polyheterocycles. A series of sequence‐defined oligomers with up to twelve repeating units, four different monomers, and various sequences were successfully synthesized. Monomer sequence was also proved to affect optical properties. We believe this strategy not only exhibits general applicability to the synthesis of group 16 conjugated oligomers and polymers, but also has far‐reaching potential for other polymer systems.

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Eintauchen in den Sequenzraum der Thiolacton‐Präzisionspolymere: eine kombinatorische Strategie zur Identifizierung funktionaler Domänen

Cited by 6 publications

References 53 publications

Von Peptiden lernen: eine Strategie für das Design funktionaler Präzisionspolymer‐Sequenzen

Von Peptiden lernen: eine Strategie für das Design funktionaler Präzisionspolymer‐Sequenzen

Iron‐Catalysed Radical Polymerisation by Living Bacteria

Homogeneous Synthesis of Monodisperse Sequence‐Defined Conjugated Oligomers by Temperature Cycling

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