Einige Versuche mit peroraler Darreichung von Insulin

Salén, Ernst B.

doi:10.1111/j.0954-6820.1924.tb15268.x

Cited by 8 publications

(2 citation statements)

References 4 publications

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“…It must be noted that the field of oral delivery of biologics is nearly a century old, with oral administration of insulin examined as early as 1923-1924 [8,9,10]. The proliferation of biological therapeutics has intensified research efforts into non-invasive delivery approaches, with oral delivery in particular attracting significant attention.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in oral delivery of biologics: nanomedicine and physical modes of delivery

Vllasaliu

Thanou

Stolnik

et al. 2018

Expert Opinion on Drug Delivery

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Research into oral delivery of biologics has a long and rich history but has not produced technologies used in the clinic. The area has evolved in terms of strategies to promote oral biologics delivery from early chemical absorption enhancers to nanomedicine to devices. Continued activity in this area is justifiable considering the remarkable proliferation of biologics. Areas covered: The article discusses some physiological barriers to oral delivery of biologics, with a special focus on less characterized barriers such as the basement membrane. Recent progress in oral delivery of biologics via nanomedicine is subsequently covered. Finally, the emerging field of device-mediated gastrointestinal delivery of biotherapeutics is discussed. Expert opinion: Oral delivery of biologics is considered a 'panacea' in drug delivery. Almost century-old approaches of utilizing chemical absorption enhancers have not produced clinically translated technologies. Nanomedicine for oral biologics delivery has demonstrated potential, but the field is relatively new, and technologies have not progressed to the clinic. Device-mediated oral biologics delivery (e.g. ultrasound or microneedles) is in its infancy. However, this space is likely to intensify owing to advances in electronics and materials, as well as the challenges and history related to clinical translation of alternative approaches.

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Section: Introductionmentioning

confidence: 99%

Recent advances in oral delivery of biologics: nanomedicine and physical modes of delivery

Vllasaliu

Thanou

Stolnik

et al. 2018

Expert Opinion on Drug Delivery

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“…Despite nearly a century of research on oral biologic delivery, the state of clinical practice today is largely unchanged in nevertheless, the increasing number of biologics on the market has accelerated this research, and when combined with recent advancements in materials, research into oral delivery of biologics is yielding more clinically relevant drug-delivery technologies that have the potential to make oral administration of biologics a practical option in terms of administration options for these therapeutics. (7)(8)(9) The process of producing biologics is outside the purview of this article; instead, it will discuss the drug delivery of biologics and recent developments in this field.…”

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confidence: 99%

Recent Advances in the Oral Delivery of Biologics

Zanjare

2024

IJSREM

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The majority of patients find that the oral route of drug administration is the most convenient, easy to follow, non- invasive, and physician-preferred method. However, oral biologic administration is not as beneficial as other routes because of mucosal permeability and various gastrointestinal barriers that limit the systemic absorption of complex macromolecules after ingestion. Because of their large molecular size, which results in extremely poor permeability across the intestinal mucosa, biologics are sensitive to the harsh environment of the gastrointestinal tract and thus play a significant role in the treatment of therapeutic interventions such as Chronic ailments, metabolic disease aging, and inflammatory disorders. Many drug delivery systems and pharmaceutical technologies, such as micelles, nano carriers, lipid-based carriers, and cyclodextrins, have been explored to enhance oral drug absorption. This article will first address the drug discovery, intensive research, and design that have enhanced the growth of biologics in recent decades and further accelerated the way we administer the medication in a clinical setting. physiological barriers to oral delivery of biologics and addresses various approaches to enhance the efficacy of oral delivery; furthermore, this conversation will encompass the diverse benefits and constraints of drug delivery systems as well as the general perception and promise of this emerging clinical area. Keywords: Absorption enhancers; biologics; drug delivery; Gastrointestinal barriers; insulin; microneedle pill; oral delivery.

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